INT116282

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Context Info
Confidence 0.75
First Reported 1999
Last Reported 2010
Negated 6
Speculated 4
Reported most in Body
Documents 83
Total Number 88
Disease Relevance 45.40
Pain Relevance 20.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp13) extracellular space (Mmp13) extracellular region (Mmp13)
Golgi apparatus (Mmp13) proteinaceous extracellular matrix (Mmp13) lysosome (Mmp13)
Anatomy Link Frequency
chondrocytes 12
cartilage 11
TMJ 4
fibroblasts 4
joints 4
Mmp13 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1196 100.00 Very High Very High Very High
metalloproteinase 1138 100.00 Very High Very High Very High
cytokine 352 99.88 Very High Very High Very High
Snapping jaw 70 99.84 Very High Very High Very High
Osteoarthritis 1465 99.78 Very High Very High Very High
Arthritis 1039 99.36 Very High Very High Very High
Inflammation 763 99.00 Very High Very High Very High
ischemia 24 98.96 Very High Very High Very High
antagonist 31 98.16 Very High Very High Very High
Leflunomide 6 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1249 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 70 99.84 Very High Very High Very High
Osteoarthritis 1555 99.78 Very High Very High Very High
Fibrosis 132 99.64 Very High Very High Very High
Arthritis 1130 99.36 Very High Very High Very High
Cv General 4 Under Development 5 99.32 Very High Very High Very High
Severe Combined Immunodeficiency 292 99.28 Very High Very High Very High
Keloid Scars 50 99.14 Very High Very High Very High
INFLAMMATION 776 99.00 Very High Very High Very High
Starvation 4 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistostaining was carried out to examine the expression of discoidin domain receptor 2 (Ddr2), a type II collagen receptor, matrix metalloproteinase-13 (Mmp-13), and Mmp-derived type II collagen fragments in the articular cartilage of condyles from the mouse TMJ.
Spec (examine) Gene_expression (expression) of Mmp-13 in TMJ
1) Confidence 0.75 Published 2009 Journal Osteoarthr. Cartil. Section Body Doc Link 19230720 Disease Relevance 0.17 Pain Relevance 0
CONCLUSION: Results indicate that partial discectomy induces early-onset OA in mouse TMJ and that increased expression of Mmp-13, likely due to the elevated expression of Ddr2, may be one of the factors responsible for the early-onset OA in mouse TMJ.


Gene_expression (expression) of Mmp-13 in TMJ
2) Confidence 0.75 Published 2009 Journal Osteoarthr. Cartil. Section Body Doc Link 19230720 Disease Relevance 0.11 Pain Relevance 0
The enzyme collagenase is produced mainly by fibroblasts and inflammatory cells and its activity is related to remodeling in wound healing [174].

7.8.

Gene_expression (produced) of collagenase in fibroblasts associated with inflammation and wound healing
3) Confidence 0.75 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2885077 Disease Relevance 1.12 Pain Relevance 0.08
Mechanical compression of the wound may induce excessive scarring and influence the release of PGE2 and the expression of collagenases.
Gene_expression (expression) of collagenase associated with injury and keloid scars
4) Confidence 0.75 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2910481 Disease Relevance 1.89 Pain Relevance 0.24
The objective of our study was to determine whether the expression of Mmp-3, Mmp-13 and Ddr2 was increased in OA-like TM joints in mutant mice using immunohistochemistry.
Spec (whether) Gene_expression (expression) of Mmp-13 in joints associated with osteoarthritis
5) Confidence 0.74 Published 2007 Journal Arch. Oral Biol. Section Abstract Doc Link 17125729 Disease Relevance 0.34 Pain Relevance 0.32
We conclude that, similar to previous observations in knee joints, the overexpression of Ddr2 and Mmp-13 may be responsible for the OA-like change in TM joints in mutant mice.
Gene_expression (overexpression) of Mmp-13 in joints associated with osteoarthritis
6) Confidence 0.74 Published 2007 Journal Arch. Oral Biol. Section Abstract Doc Link 17125729 Disease Relevance 0.39 Pain Relevance 0.31
Immunohistostaining was carried out to examine the expression of discoidin domain receptor 2 (Ddr2), a type II collagen receptor, matrix metalloproteinase-13 (Mmp-13), and Mmp-derived type II collagen fragments in the articular cartilage of condyles from the mouse TMJ.
Spec (examine) Gene_expression (expression) of metalloproteinase-13 in TMJ
7) Confidence 0.66 Published 2009 Journal Osteoarthr. Cartil. Section Body Doc Link 19230720 Disease Relevance 0.17 Pain Relevance 0
In addition, we showed that in live oocytes the relocalization of Mps1 and Polo to filaments is sensitive to injection of collagenase, suggesting that the structural components of the filaments are composed of collagen-like fibrils.
Gene_expression (injection) of collagenase in filaments
8) Confidence 0.65 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2761730 Disease Relevance 0.27 Pain Relevance 0
2 in cultured human osteoarthritic cartilage has been shown to be associated with decreased expression of collagenases, cytokines, genes associated with chondrocyte hypertrophy, and upregulation of prostaglandin (PG)E2 production.
Gene_expression (expression) of collagenase in chondrocyte associated with hypertrophy, osteoarthritis and cytokine
9) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206385 Disease Relevance 0.72 Pain Relevance 0.05
Previous studies, however, have shown that multiple tetracyclines can inhibit collagenase MMPs via down-regulation of gene expression in a cellular model of rheumatoid arthritis using cultured chondrocytes [33] and that pre-treatment with minocycline down-regulates pro-MMP expression after permanent cerebral ischemia [17].
Gene_expression (expression) of collagenase in chondrocytes associated with cv general 4 under development, ischemia and rheumatoid arthritis
10) Confidence 0.65 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1543649 Disease Relevance 0.70 Pain Relevance 0.21
After seven days in the original mass plating, they were then freed with collagenase/dispase, washed in phosphate buffered saline (PBS), and singly and sparsely replated in triplicate in a similar medium on 35 mm collagen coated plates for individual cell clonal growth.
Gene_expression (freed) of collagenase
11) Confidence 0.65 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254966 Disease Relevance 0.07 Pain Relevance 0
For both a crude collagenase fraction (Figure 4A) and a purified enzyme (Figure 4B) the localization of GFP-Mps1 and GFP-Polo to filaments was eliminated around the injection site, with injection of concentrations as low as 100 µg/ml causing disruption.
Gene_expression (fraction) of collagenase in filaments
12) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2761730 Disease Relevance 0.10 Pain Relevance 0
Irsogladine failed to inhibit proliferation, tubular formation, and the uPA/MMP-1 mRNA expression of HUVEC cells.
Gene_expression (expression) of MMP-1
13) Confidence 0.65 Published 2004 Journal Breast Cancer Res. Treat. Section Abstract Doc Link 14758089 Disease Relevance 1.01 Pain Relevance 0.08
We also found that the overexpression of matrix metalloproteinase 13 (Mmp-13) was probably due to the up-regulation of a collagen receptor, discoidin domain receptor 2 (Ddr2), which was responsible for knee cartilage degeneration in mutant mice.
Gene_expression (overexpression) of metalloproteinase 13 in cartilage associated with metalloproteinase
14) Confidence 0.65 Published 2007 Journal Arch. Oral Biol. Section Abstract Doc Link 17125729 Disease Relevance 0.35 Pain Relevance 0.30
We also found that the overexpression of matrix metalloproteinase 13 (Mmp-13) was probably due to the up-regulation of a collagen receptor, discoidin domain receptor 2 (Ddr2), which was responsible for knee cartilage degeneration in mutant mice.
Gene_expression (overexpression) of Mmp-13 in cartilage associated with metalloproteinase
15) Confidence 0.65 Published 2007 Journal Arch. Oral Biol. Section Abstract Doc Link 17125729 Disease Relevance 0.35 Pain Relevance 0.30
Age-dependent increase of discoidin domain receptor 2 and matrix metalloproteinase 13 expression in temporomandibular joint cartilage of type IX and type XI collagen-deficient mice.
Gene_expression (expression) of metalloproteinase 13 in temporomandibular joint associated with snapping jaw and metalloproteinase
16) Confidence 0.65 Published 2007 Journal Arch. Oral Biol. Section Title Doc Link 17125729 Disease Relevance 0.36 Pain Relevance 0.35
We found that the staining for Ddr2, Mmp-13 and Mmp-derived type II collagen fragments in tissue sections from 6-month-old mice was increased in TM joints of the mutant mice.
Gene_expression (staining) of Mmp-13 in joints
17) Confidence 0.65 Published 2007 Journal Arch. Oral Biol. Section Abstract Doc Link 17125729 Disease Relevance 0.33 Pain Relevance 0.32
However, MMP-13 is five times more effective at degrading collagen type II than MMP-1,15 suggesting that small changes in the expression level of MMP-13 may have severe consequences for the cartilage integrity.
Gene_expression (expression) of MMP-13 in cartilage
18) Confidence 0.64 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.89 Pain Relevance 0.30
Cleaved fragments of collagen type II again can further induce MMP-13 gene expression and result in a cycle of collagen degradation.
Gene_expression (expression) of MMP-13
19) Confidence 0.64 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.79 Pain Relevance 0.29
The analysis of MMP-1 in mouse and rabbit models of arthritis is problematic because MMP-1 is present in rabbits and humans, but functionally absent in mice, whereas MMP-13 is present in all.16 17 Murine collagenase-like A (McolA) and McolB are counterparts of the human interstitial collagenase (MMP-1) with a high percentage of identities (58% in amino acids and 74% in nucleotides) but only present during mouse embryogenesis.
Neg (absent) Gene_expression (present) of MMP-13 associated with arthritis
20) Confidence 0.64 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.60 Pain Relevance 0.23

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