INT116288

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Context Info
Confidence 0.42
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 4
Total Number 4
Disease Relevance 1.69
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pparg) signal transduction (Pparg) nucleus (Pparg)
enzyme binding (Pparg) DNA binding (Pparg) cytoplasm (Pparg)
Anatomy Link Frequency
MCF-7 1
Pparg (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 8 100.00 Very High Very High Very High
imagery 1 99.92 Very High Very High Very High
Inflammation 4 98.16 Very High Very High Very High
aspirin 3 96.32 Very High Very High Very High
cINOD 9 79.84 Quite High
Abeta 1 65.96 Quite High
Hippocampus 1 59.04 Quite High
diclofenac 4 50.00 Quite Low
Neuropeptide 1 25.00 Low Low
Pain 1 10.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 33 98.56 Very High Very High Very High
INFLAMMATION 8 98.16 Very High Very High Very High
Breast Cancer 60 97.80 Very High Very High Very High
Disease 9 95.76 Very High Very High Very High
Amyloid Plaque 1 92.64 High High
Cancer 45 90.48 High High
Targeted Disruption 6 82.76 Quite High
Alzheimer's Dementia 1 66.52 Quite High
Hyperplasia 14 43.80 Quite Low
Death 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Down-regulation of PPARgamma1 suppresses cell growth and induces apoptosis in MCF-7 breast cancer cells

Background

Negative_regulation (regulation) of PPARgamma1 in MCF-7 associated with breast cancer and apoptosis
1) Confidence 0.42 Published 2008 Journal Mol Cancer Section Title Doc Link PMC2614423 Disease Relevance 0.88 Pain Relevance 0
Autoradiographical imaging of PPARgamma agonist effects on PBR/TSPO binding in TASTPM mice.
Negative_regulation (effects) of PPARgamma associated with agonist and imagery
2) Confidence 0.41 Published 2009 Journal Exp. Neurol. Section Title Doc Link 19320004 Disease Relevance 0.81 Pain Relevance 0.30
These drugs also activated peroxisome proliferator-activated receptor gamma (PPARgamma) at concentration ranges that increase TFF2 expression, and upregulated TFF2 expression was suppressed by GW9662, a specific inhibitor of PPARgamma.
Negative_regulation (inhibitor) of PPARgamma
3) Confidence 0.13 Published 2004 Journal FEBS Lett. Section Abstract Doc Link 14759512 Disease Relevance 0 Pain Relevance 0.33
Other novel MOAs may include the inhibition of substrate P, inhibition of peroxisome proliferator activated receptor gamma (PPARgamma), blockage of acid-sensing ion channels, alteration of interleukin-6 production, and inhibition of N-methyl-D-aspartate (NMDA) receptor hyperalgesia.
Negative_regulation (inhibition) of peroxisome proliferator activated receptor gamma
4) Confidence 0.09 Published 2010 Journal Curr Med Res Opin Section Body Doc Link 20470236 Disease Relevance 0 Pain Relevance 0

General Comments

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