INT116314

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2010
Negated 6
Speculated 3
Reported most in Body
Documents 38
Total Number 45
Disease Relevance 16.60
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Myod1) nucleus (Myod1) enzyme binding (Myod1)
DNA binding (Myod1) transcription factor binding (Myod1) cytoplasm (Myod1)
Anatomy Link Frequency
muscle 8
myoblasts 7
skeletal muscle 5
myotubes 3
Fibroblasts 2
Myod1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 17 93.92 High High
withdrawal 2 90.52 High High
fibrosis 192 82.16 Quite High
cytokine 38 70.64 Quite High
cva 1 66.00 Quite High
depression 5 63.00 Quite High
dexamethasone 2 55.72 Quite High
vincristine 2 37.44 Quite Low
tolerance 12 34.88 Quite Low
Neurotransmitter 44 27.84 Quite Low
Disease Link Frequency Relevance Heat
Helminth Infection 14 100.00 Very High Very High Very High
Cardiomyopathy 315 99.96 Very High Very High Very High
Muscular Dystrophy 838 98.08 Very High Very High Very High
Pulmonary Disease 98 98.00 Very High Very High Very High
Sarcoma 83 97.36 Very High Very High Very High
Hypopituitarism 151 96.84 Very High Very High Very High
Targeted Disruption 175 96.80 Very High Very High Very High
Primitive Neuroectodermal Tumors 54 95.92 Very High Very High Very High
Muscular Atrophy 58 95.72 Very High Very High Very High
Starvation 46 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression levels of these marker genes confirmed the accuracy of the dissection protocol since the relative levels of Myod1 expression in the Achilles tendon and spinal ligament were negligible as was the expression of Col2a1 in the skeletal muscle.
Gene_expression (expression) of Myod1 in skeletal muscle
1) Confidence 0.70 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.08 Pain Relevance 0
The expression levels of Col1a1 (a positive marker for tendon, ligament and skeletal muscle), Col2a1 (a negative marker for the same tissues), Myod1 (a positive marker for skeletal muscle and a negative marker for tendon) and Comp were determined at 3 weeks of age by quantitative real-time PCR (Supplementary Material, Table S1).
Spec (determined) Gene_expression (expression) of Myod1 in ligament
2) Confidence 0.70 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.27 Pain Relevance 0
The Myf5nlacZ/nlacZ:Myod?
Gene_expression (The) of Myod
3) Confidence 0.54 Published 2010 Journal Bone Section Body Doc Link PMC2860222 Disease Relevance 0.27 Pain Relevance 0
The Myf5nlacZ/nlacZ:Myod?
Gene_expression (/) of Myod
4) Confidence 0.54 Published 2010 Journal Bone Section Body Doc Link PMC2860222 Disease Relevance 0.27 Pain Relevance 0
As MyoD is not expressed in the heart, any myocardial changes that are seen are the result of increased muscle damage and worse muscle regeneration.
Neg (not) Gene_expression (expressed) of MyoD in muscle
5) Confidence 0.49 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.97 Pain Relevance 0.11
MyoD is basic-helix-loop-helix myogenic determination transcription factor that is not expressed in the heart but is expressed in all skeletal muscle committed cells.
Neg (not) Gene_expression (expressed) of MyoD in skeletal muscle
6) Confidence 0.49 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.72 Pain Relevance 0
MyoD is basic-helix-loop-helix myogenic determination transcription factor that is not expressed in the heart but is expressed in all skeletal muscle committed cells.
Gene_expression (expressed) of MyoD in heart
7) Confidence 0.49 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.72 Pain Relevance 0
MyoD is basic-helix-loop-helix myogenic determination transcription factor that is not expressed in the heart but is expressed in all skeletal muscle committed cells.
Gene_expression (expressed) of myogenic determination in heart
8) Confidence 0.43 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.71 Pain Relevance 0
MyoD is basic-helix-loop-helix myogenic determination transcription factor that is not expressed in the heart but is expressed in all skeletal muscle committed cells.
Neg (not) Gene_expression (expressed) of myogenic determination in skeletal muscle
9) Confidence 0.43 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.71 Pain Relevance 0
combined developed muscle hypotrophy, associated with decreased MyoD levels, through a mechanism involving NF-?
Gene_expression (levels) of MyoD in muscle
10) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.58 Pain Relevance 0.03
Reduced MyoD levels, but unchanged NF-?
Gene_expression (levels) of MyoD
11) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.59 Pain Relevance 0.03
Satellite cell phenotype is defined by the differential expression of specific factors, among which Pax7, MyoD and myogenin.
Gene_expression (expression) of MyoD in Satellite cell
12) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965098 Disease Relevance 0.35 Pain Relevance 0.07
At present, the most consistent and reliable marker for satellite cells is the paired-box transcription factor Pax7 and formation of satellite cells occurs via the expression of Pax7 and MyoD and/or Myf5 [30], [31], [32].
Gene_expression (expression) of MyoD in satellite cells
13) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.14 Pain Relevance 0
Single Sk-34 cells typically showed no expression of Myf5, Pax3, Pax7, VE-cadherin or Nkx2.5, lower % expression of MyoD, M-cadherin, Cacn-1b, TEK, cardiac actin, GATA-4, Mef2c, Hand2 and isl-1, and higher (>50%) expression of c-met, Scn-1b, ?
Gene_expression (expression) of MyoD in TEK
14) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2262151 Disease Relevance 0.08 Pain Relevance 0
No studies have so far investigated whether alterations in MyoD and Id expression also occur in skeletal muscle from patients with COPD and whether they also suffer from an impaired skeletal muscle regenerative capacity.


Gene_expression (expression) of MyoD in skeletal muscle associated with pulmonary disease
15) Confidence 0.27 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695204 Disease Relevance 0.62 Pain Relevance 0
Use of fibroblasts as a starting point allowed monitoring of myogenic differentiation defects in DM1 cells upon inducible overexpression of MYOD, the sole transcription factor necessary to convert fibroblast cells into myoblasts [44].
Gene_expression (overexpression) of MYOD in fibroblast
16) Confidence 0.27 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.34 Pain Relevance 0
As shown in Fig. (1B), MYOD protein expression was barely detectable by Western blot 24 h after treatment of immortalized fibroblasts with doxycycline (myoblasts), but was significantly increased upon differentiation of myoblasts into myotubes for 3-7 days.
Gene_expression (expression) of MYOD in myoblasts
17) Confidence 0.27 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.31 Pain Relevance 0
Generation of Inducible MYOD Construct
Gene_expression (Generation) of MYOD
18) Confidence 0.27 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.32 Pain Relevance 0
Decreased MYOD expression has previously been reported in cells overexpressing transcripts with a CUGexp [45], and more recently in muscle biopsy samples of DM1 patients [46].
Gene_expression (expression) of MYOD in muscle
19) Confidence 0.27 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.07 Pain Relevance 0
Lentivirus expressing MYOD or CLCN1-luc was produced by co-transfection of 10 µg MyoD/pTREautoR3 or CLCN1-luc/pLenti6/V5-D-TOPO DNA with RRE, REV and VSV-g packaging vectors (6.5 µg, 2.5 µg and 3.5 µg, respectively) into 293Tcells, and viral supernatant was harvested as described above.


Gene_expression (expressing) of MYOD
20) Confidence 0.27 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0 Pain Relevance 0

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