INT11634

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1987
Last Reported 2010
Negated 2
Speculated 6
Reported most in Body
Documents 24
Total Number 30
Disease Relevance 20.06
Pain Relevance 4.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINE1) extracellular region (SERPINE1) plasma membrane (SERPINE1)
Anatomy Link Frequency
stellate cells 2
adipose tissue 2
extracellular matrix 2
lymph node 1
plasma 1
SERPINE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 41 100.00 Very High Very High Very High
dexamethasone 2 99.60 Very High Very High Very High
cINOD 7 98.96 Very High Very High Very High
Inflammation 85 98.44 Very High Very High Very High
Angina 7 95.04 Very High Very High Very High
Migraine 76 94.40 High High
metalloproteinase 3 89.92 High High
anesthesia 40 85.44 High High
COX2 1 83.92 Quite High
alcohol 11 81.84 Quite High
Disease Link Frequency Relevance Heat
Stress 68 100.00 Very High Very High Very High
Cirrhosis 40 100.00 Very High Very High Very High
Obesity 43 99.84 Very High Very High Very High
Sprains And Strains 68 99.24 Very High Very High Very High
INFLAMMATION 112 98.84 Very High Very High Very High
Atherosclerosis 4 98.56 Very High Very High Very High
Ventricular Remodeling 1 98.40 Very High Very High Very High
Breast Cancer 231 98.00 Very High Very High Very High
Cancer 266 97.20 Very High Very High Very High
Myocardial Infarction 13 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the importance of adipose tissue in the regulation of the PAI-1 plasma level is not known.
Regulation (regulation) of PAI-1 in adipose tissue associated with obesity
1) Confidence 0.62 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10323791 Disease Relevance 0.72 Pain Relevance 0.06
The effects of TNF alpha and TGF-beta on PAI-1 antigen levels were both time- and concentration-dependent; optimum doses being 10-100 pM TNF alpha and 0.4-0.8 nM TGF-beta, with each cytokine exerting its effect on PAI-1 antigen levels within 8 h of addition to culture.
Regulation (effect) of PAI-1 associated with cytokine
2) Confidence 0.57 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 8054359 Disease Relevance 0.40 Pain Relevance 0.39
However, it appears that the cagPAI and the region surrounding it had been exchanged by the Amerindian strains in Peru, where, the human population underwent major changes in recent history with the arrival of European conquerors and settlers.
Regulation (exchanged) of cagPAI associated with sprains and strains
3) Confidence 0.35 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553449 Disease Relevance 0.85 Pain Relevance 0
In this study, we investigated the prognostic value of uPA and PAI-1 at the mRNA level in lymph node- and hormone receptor-positive breast cancer.


Spec (investigated) Regulation (value) of PAI-1 in lymph node associated with breast cancer
4) Confidence 0.27 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1564186 Disease Relevance 0.48 Pain Relevance 0
For the univariate and multivariate analyses, we investigated the prognostic value of uPA and PAI-1 mRNA levels by using the median of expression generating "high" and "low" level groups.
Spec (investigated) Regulation (value) of PAI-1 mRNA
5) Confidence 0.27 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.95 Pain Relevance 0
We investigated the prognostic value of uPA and PAI-1 mRNA levels by considering the median of expression as a cut-off generating a "high" and a "low" level group.
Spec (investigated) Regulation (value) of PAI-1 mRNA
6) Confidence 0.27 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.44 Pain Relevance 0
UPA and PAI-1 mRNA values were compared with clinical, histological and biological features of tumors using appropriate statistical tests.
Regulation (values) of PAI-1 mRNA associated with cancer
7) Confidence 0.27 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.70 Pain Relevance 0
Univariate and multivariate analysis of uPA and PAI-1 mRNA values for BCS
Regulation (values) of PAI-1 mRNA
8) Confidence 0.27 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.97 Pain Relevance 0
This high pathogenicity has been shown to be associated with molecular changes in the polymerase genes PA and PB1 (17).
Regulation (changes) of PA
9) Confidence 0.26 Published 2008 Journal Emerging Infectious Diseases Section Body Doc Link PMC2570914 Disease Relevance 0.61 Pain Relevance 0
Table 1 lists differences in RNA expression values of PAI-1, COX-2 and ERBB2 for paired samples of each patient.
Regulation (values) of PAI-1
10) Confidence 0.26 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779463 Disease Relevance 0.24 Pain Relevance 0.13
Circulating Levels of Inflammatory Markers in Intrauterine Growth Restriction

We aimed to investigate possible alterations in circulating levels of the perinatal stress markers high sensitivity (hs)-CRP, PAI-1, and S100B—probably reflecting brain and adipose tissue inflammation—in intrauterine growth-restricted-(IUGR) and appropriate-for-gestational-age-(AGA) pregnancies, given that these groups differ in fat mass and metabolic mechanisms involving aseptic inflammation.

Spec (possible) Regulation (alterations) of PAI-1 in brain associated with stress, inflammation and obesity
11) Confidence 0.26 Published 2010 Journal Mediators of Inflammation Section Title Doc Link PMC2896837 Disease Relevance 0.77 Pain Relevance 0.21
The anti-inflammatory drugs, indomethacin and dexamethasone, did not appear to modulate PAI-1 levels in cultures of cartilage tissue.
Regulation (modulate) of PAI-1 in cartilage associated with inflammation, cinod and dexamethasone
12) Confidence 0.25 Published 1994 Journal Biochim. Biophys. Acta Section Abstract Doc Link 8054359 Disease Relevance 0.40 Pain Relevance 0.42
The regulation of plasminogen activator inhibitor 1 concentration in plasma is complex and at present not well understood.
Regulation (regulation) of activator inhibitor 1 in plasma
13) Confidence 0.24 Published 1996 Journal Curr. Opin. Hematol. Section Abstract Doc Link 9372104 Disease Relevance 0.50 Pain Relevance 0.08
Eight genes perfectly discriminated between groups A and B (AUC-ROC, 1.000): seven up-regulated genes (PAI1, THBS1, IL8, PTGS2, CXCR4, JUN, and FOS) and one down-regulated gene (IHH).
Regulation (regulated) of PAI1
14) Confidence 0.23 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.20 Pain Relevance 0.04
effects in hepatic stellate cells.27 Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of both the urokinase-type plasminogen activator and the tissue plasminogen activator and thereby plays an important role in regulation of the fibrinolytic system.
Regulation (effects) of PAI-1 in stellate cells associated with cirrhosis
15) Confidence 0.23 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 1.18 Pain Relevance 0.27
effects in hepatic stellate cells.27 Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of both the urokinase-type plasminogen activator and the tissue plasminogen activator and thereby plays an important role in regulation of the fibrinolytic system.
Regulation (effects) of activator inhibitor-1 in stellate cells associated with cirrhosis
16) Confidence 0.20 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 1.17 Pain Relevance 0.27
Drugs able to modulate PAI activity may be useful in clinical conditions at high risk of thrombotic vascular complications like diabetics with stable angina.
Regulation (modulate) of PAI associated with angina and diabetes mellitus
17) Confidence 0.17 Published 1992 Journal Thromb. Res. Section Abstract Doc Link 1579896 Disease Relevance 0.93 Pain Relevance 0.17
The aim of the study was to assess the effect of cardiothoracic surgery on the dynamics of plasminogen, D-dimers and plasminogen activator inhibitor (PAI-I) during the first 24 h after surgery.
Regulation (effect) of PAI-I
18) Confidence 0.12 Published 2005 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 15653441 Disease Relevance 0 Pain Relevance 0.08
We investigated the prognostic value of uPA and PAI-1 at the mRNA level as measured by real-time quantitative RT-PCR.


Spec (investigated) Regulation (value) of PAI-1
19) Confidence 0.12 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1564186 Disease Relevance 0.66 Pain Relevance 0
The 26 genes that were significantly dysregulated (23 up-regulated and three down-regulated) in the group B samples mainly encoded proteins involved in immune response (interferon pathway, growth factor, growth factor receptor, cytokine: IL8, CXCR4, CCL2, CXCL1, IL6, CCL3, CCL4, LIF) and matrix remodeling (angiogenesis, extracellular matrix, extracellular matrix protease, inhibitors of matrix protease: PAI1, THBS1, PTGS2, HIF1A, MMP9, CTGF, HAS2, PAI2, and MMP2).
Regulation (dysregulated) of PAI1 in extracellular matrix associated with cytokine
20) Confidence 0.10 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.99 Pain Relevance 0.17

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox