INT116347

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 3.63
Pain Relevance 11.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRIN1)
Anatomy Link Frequency
plasma 4
pyramidal cells 2
GRIN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 180 100.00 Very High Very High Very High
Kinase C 6 100.00 Very High Very High Very High
opioid receptor 18 99.98 Very High Very High Very High
long-term potentiation 223 99.84 Very High Very High Very High
Anterior cingulate cortex 91 99.62 Very High Very High Very High
Hyperalgesia 12 99.56 Very High Very High Very High
Glutamate 35 99.48 Very High Very High Very High
central sensitization 4 98.84 Very High Very High Very High
ascending facilitation 7 98.80 Very High Very High Very High
Pyramidal cell 27 98.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 14 99.56 Very High Very High Very High
Stress 84 99.36 Very High Very High Very High
Pain 136 97.72 Very High Very High Very High
Anxiety Disorder 58 97.04 Very High Very High Very High
Depression 31 96.64 Very High Very High Very High
Hypersensitivity 1 93.72 High High
Injury 42 86.60 High High
Ganglion Cysts 4 84.28 Quite High
Headache 78 83.84 Quite High
Post Operative Pain 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In both cotransfected cells and cultured hippocampal neurons the activation of NMDA receptors increases the number of D1 receptors on the plasma membrane surface and enhances D1 receptor-mediated cAMP accumulation via a SNARE-dependent mechanism.
Positive_regulation (increases) of Positive_regulation (activation) of NMDA in plasma associated with nmda receptor
1) Confidence 0.49 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14762133 Disease Relevance 0 Pain Relevance 0.48
Furthermore, activation of NK1 receptors or NMDA receptors is required for LTP.
Positive_regulation (required) of Positive_regulation (activation) of NMDA associated with nmda receptor and long-term potentiation
2) Confidence 0.49 Published 2007 Journal Mol Pain Section Body Doc Link PMC1904186 Disease Relevance 0.43 Pain Relevance 1.29
This process involves DOR regulation of MORs, MOR-induced activation of NMDARs (probably via the regulation of Src, recruiting PKC and Galpha subunits) and the NMDAR-mediated activation of CaMKII.
Positive_regulation (induced) of Positive_regulation (activation) of NMDAR associated with kinase c and opioid receptor
3) Confidence 0.49 Published 2008 Journal Curr Drug Abuse Rev Section Abstract Doc Link 19630721 Disease Relevance 0.12 Pain Relevance 1.48
This process involves DOR regulation of MORs, MOR-induced activation of NMDARs (probably via the regulation of Src, recruiting PKC and Galpha subunits) and the NMDAR-mediated activation of CaMKII.
Positive_regulation (induced) of Positive_regulation (activation) of NMDAR associated with kinase c and opioid receptor
4) Confidence 0.49 Published 2008 Journal Curr Drug Abuse Rev Section Abstract Doc Link 19630721 Disease Relevance 0.12 Pain Relevance 1.45
Acute receptor desensitization via uncoupling of the receptor from G-proteins, upregulation of the cAMP pathway, activation of the N-methyl-D-aspartate (NMDA)-receptor system, as well as descending facilitation, have been proposed as potential mechanisms underlying opioid-induced hyperalgesia.
Positive_regulation (upregulation) of Positive_regulation (activation) of NMDA associated with hyperalgesia, ascending facilitation and opioid
5) Confidence 0.49 Published 2007 Journal Best Pract Res Clin Anaesthesiol Section Abstract Doc Link 17489220 Disease Relevance 0.84 Pain Relevance 1.42
Our results demonstrate that the D1-NR1 physical interaction enables NMDA receptors to increase plasma membrane insertion of D1 receptors and provides a novel mechanism by which the activation of NMDA receptors upregulates D1 receptor function.
Positive_regulation (upregulates) of Positive_regulation (activation) of NMDA in plasma associated with nmda receptor
6) Confidence 0.49 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14762133 Disease Relevance 0 Pain Relevance 0.47
However, conditions facilitating NMDA receptor activation, such as low magnesium medium, or direct exogenous activation of NMDA receptors, may affect SPW-R activity [64].
Positive_regulation (facilitating) of Positive_regulation (activation) of NMDA associated with nmda receptor
7) Confidence 0.45 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1950312 Disease Relevance 0 Pain Relevance 0.22
In contrast, theta-burst potentiation (see Additional File 2 for information on different stimulation protocols), which requires activation of both NMDA receptors and voltage-dependent Ca2+-channels was not affected by corticosterone treatment.
Positive_regulation (requires) of Positive_regulation (activation) of NMDA associated with nmda receptor
8) Confidence 0.45 Published 2010 Journal Mol Brain Section Body Doc Link PMC2841592 Disease Relevance 0 Pain Relevance 0.35
Central sensitization phenomena to which the hyperalgesia is connected seem to depend significantly from the NMDA and mGluR receptors activation operated by glutamate [2].
Positive_regulation (depend) of Positive_regulation (activation) of NMDA associated with glutamate, hyperalgesia and central sensitization
9) Confidence 0.01 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2771268 Disease Relevance 0.78 Pain Relevance 1.07
One major feature of LTP is the requirement of activation of NMDA receptors.
Positive_regulation (requirement) of Positive_regulation (activation) of NMDA associated with nmda receptor and long-term potentiation
10) Confidence 0.01 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0.95 Pain Relevance 1.40
In the ACC, bath application of a NMDA receptor antagonist AP-5 completely abolished the induction of LTP induced by different induction protocols in the pyramidal cells [16], indicting that the induction of ACC LTP is completely dependent of postsynaptic activation of NMDA receptors.


Positive_regulation (dependent) of Positive_regulation (activation) of NMDA in pyramidal cells associated with nmda receptor antagonist, nmda receptor, pyramidal cell, long-term potentiation and anterior cingulate cortex
11) Confidence 0.01 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0 Pain Relevance 1.25
at least requires NMDA-receptor activation at the time of stress
Positive_regulation (requires) of Positive_regulation (activation) of NMDA associated with stress
12) Confidence 0.01 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC1847472 Disease Relevance 0.39 Pain Relevance 0.57

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