INT116349

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 8
Disease Relevance 2.56
Pain Relevance 3.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NDOR1) oxidoreductase activity (NDOR1) cell death (NDOR1)
nucleus (NDOR1) cytoplasm (NDOR1)
Anatomy Link Frequency
embryonic kidney 4
tail 2
dorsal horn 2
NDOR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 16 99.38 Very High Very High Very High
Dorsal horn 1 99.20 Very High Very High Very High
nMDA receptor antagonist 3 94.16 High High
antagonist 13 93.60 High High
Morphine 6 91.68 High High
Thermal hyperalgesia 2 89.08 High High
allodynia 6 88.08 High High
adenocard 6 86.56 High High
Glutamate 6 86.08 High High
opiate 6 84.64 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 4 99.04 Very High Very High Very High
Apoptosis 6 90.88 High High
Death 6 90.36 High High
Hyperalgesia 2 89.08 High High
Neuropathic Pain 8 88.08 High High
Toxicity 6 75.00 Quite High
Pain 2 75.00 Quite High
Injury 1 75.00 Quite High
Drug Induced Neurotoxicity 6 5.00 Very Low Very Low Very Low
Schizophrenia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The loss of membrane integrity induced by heroin was more evident in cells transfected with NR1/NR2B than in cells transfected with NR1 alone or NR1/NR2A.
Positive_regulation (transfected) of Gene_expression (transfected) of NR1
1) Confidence 0.47 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17105944 Disease Relevance 0.23 Pain Relevance 0.31
Incubation with heroin for 24 h induced a dose-dependent decrease in cell viability both in NR1-transfected and nontransfected cells.
Positive_regulation (transfected) of Gene_expression (transfected) of NR1
2) Confidence 0.47 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17105944 Disease Relevance 0.24 Pain Relevance 0.31
Human embryonic kidney (HEK293) cells, which do not express native NMDAR, were transfected with NR1/NR2A or NR1/NR2B subunits.
Positive_regulation (transfected) of Gene_expression (transfected) of NR1 in embryonic kidney
3) Confidence 0.47 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17105944 Disease Relevance 0.26 Pain Relevance 0.31
The loss of membrane integrity induced by heroin was more evident in cells transfected with NR1/NR2B than in cells transfected with NR1 alone or NR1/NR2A.
Positive_regulation (transfected) of Gene_expression (transfected) of NR1
4) Confidence 0.47 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17105944 Disease Relevance 0.22 Pain Relevance 0.31
Human embryonic kidney (HEK293) cells, which do not express native NMDAR, were transfected with NR1/NR2A or NR1/NR2B subunits.
Positive_regulation (transfected) of Gene_expression (transfected) of NR1 in embryonic kidney
5) Confidence 0.47 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17105944 Disease Relevance 0.26 Pain Relevance 0.32
The loss of membrane integrity induced by heroin was more evident in cells transfected with NR1/NR2B than in cells transfected with NR1 alone or NR1/NR2A.
Positive_regulation (transfected) of Gene_expression (transfected) of NR1
6) Confidence 0.41 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17105944 Disease Relevance 0.22 Pain Relevance 0.31
Secondly, we used immunoblotting and immunohistochemistry to investigate the effects of nerve injury on NMDA receptor subunit expression, revealing increased expression of NR2B, but not NR2A and reduced NR1 in the superficial dorsal horn.
Positive_regulation (increased) of Gene_expression (expression) of NR1 in dorsal horn associated with nervous system injury, nmda receptor and dorsal horn
7) Confidence 0.09 Published 2005 Journal Pain Section Abstract Doc Link 16150544 Disease Relevance 1.13 Pain Relevance 1.51
Furthermore, overexpression of mini-genes encoding either NR1 or D1 carboxyl tail fragments disrupts the D1-NR1 direct protein-protein interaction and abolishes NMDA-induced changes in both D1 cell surface expression and D1-mediated cAMP accumulation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NR1 in tail
8) Confidence 0.03 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14762133 Disease Relevance 0 Pain Relevance 0.49

General Comments

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