INT11635

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Context Info
Confidence 0.68
First Reported 1989
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 35
Total Number 36
Disease Relevance 24.57
Pain Relevance 4.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINE1) extracellular region (SERPINE1) plasma membrane (SERPINE1)
Anatomy Link Frequency
endothelial cells 6
plasma 2
blood 2
cartilage 2
epithelial cells 2
SERPINE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 158 100.00 Very High Very High Very High
Kinase C 40 99.72 Very High Very High Very High
cINOD 20 99.42 Very High Very High Very High
metalloproteinase 41 99.36 Very High Very High Very High
bDMF 42 99.16 Very High Very High Very High
bradykinin 41 98.80 Very High Very High Very High
palliative 10 97.32 Very High Very High Very High
cytokine 73 95.72 Very High Very High Very High
Inflammation 302 94.76 High High
Inflammatory response 16 94.00 High High
Disease Link Frequency Relevance Heat
Pulmonary Fibrosis 126 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 144 99.96 Very High Very High Very High
Obesity 196 99.84 Very High Very High Very High
Cancer 298 99.76 Very High Very High Very High
Colon Cancer 37 99.76 Very High Very High Very High
Diabetes Mellitus 712 99.72 Very High Very High Very High
Disease 390 99.68 Very High Very High Very High
Pneumonia 10 99.66 Very High Very High Very High
Keloid Scars 25 99.64 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 4 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The NSAID naproxen (30 micrograms/ml) induced the expression of PAI-1 mRNA over basal levels and super-induced the inhibitor's expression above rhIL-1 beta stimulated levels.
Positive_regulation (induced) of Gene_expression (expression) of PAI-1 mRNA associated with cinod
1) Confidence 0.68 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7525383 Disease Relevance 0.11 Pain Relevance 0.23
PMA, an activator of protein kinase C, transiently increased (maximum 3 h) the expression of PAI-1 mRNA by approximately 10-fold, especially the 3.2 kb species.
Positive_regulation (increased) of Gene_expression (expression) of PAI-1 mRNA associated with kinase c
2) Confidence 0.68 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7525383 Disease Relevance 0.22 Pain Relevance 0.27
To verify whether the higher expression levels of PAI-1 and COX-2 observed in STs could have been induced by the preceding CB procedure, we compared the expression levels of the same genes in an independent population of 317 primary breast cancer patients.
Positive_regulation (induced) of Gene_expression (levels) of PAI-1 associated with breast cancer
3) Confidence 0.66 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779463 Disease Relevance 0.37 Pain Relevance 0.11
The suppressive action of the two drugs on the synthesis of uPA, while stimulating PAI-1 production, may have a positive impact on the balance of plasminogen activator/inhibitor, which could help reduce cartilage catabolism.


Positive_regulation (stimulating) of Gene_expression (production) of PAI-1 in cartilage
4) Confidence 0.65 Published 1997 Journal Clin. Exp. Rheumatol. Section Body Doc Link 9272300 Disease Relevance 0.08 Pain Relevance 0
The resulting proteins are secreted and lead to increased expression of plasminogen activator inhibitor-1 (PAI1).
Positive_regulation (increased) of Gene_expression (expression) of PAI1
5) Confidence 0.62 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.41 Pain Relevance 0
Increased circulating levels of vWF, PAI-1, t-PA, TFPI, and s-TM have been reported in patients with NIDDM (Collier et al 1992; McGill et al 1994; Bagg et al 2001; Aso et al 2002; Leurs et al 2002; Rigla et al 2006).
Positive_regulation (Increased) of Gene_expression (levels) of PAI-1 associated with diabetes mellitus
6) Confidence 0.55 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 1.21 Pain Relevance 0.04
Interestingly, the expression levels of TrkB and PAI-1 were elevated in the AD samples.
Positive_regulation (elevated) of Gene_expression (expression) of PAI-1 associated with disease
7) Confidence 0.52 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.75 Pain Relevance 0.58
These results emphasize the role of adipose tissue in determining plasma levels of PAI-1, with a local contribution of TNF-alpha and TGF-beta in PAI-1 production by adipose tissue.
Positive_regulation (contribution) of Gene_expression (production) of PAI-1 in adipose tissue associated with obesity
8) Confidence 0.50 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10323791 Disease Relevance 0.91 Pain Relevance 0.07
Nevertheless, in metastatic breast cancer, retrospective studies showed that elevated uPA or PAI-1 present in the primary tumor are associated with a poor response to later palliative endocrine therapy [14] suggesting that high levels of uPA and/or PAI-1 do reflect an aggressive phenotype that may be overcome by early systemic therapy in the adjuvant setting but not by palliative therapy at a later stage of the disease.
Positive_regulation (elevated) of Gene_expression (present) of PAI-1 associated with cancer, disease, advanced or metastatic breast cancer and palliative
9) Confidence 0.50 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.86 Pain Relevance 0.23
Metastasis-free Survival (MFS) and Breast Cancer specific Survival (BCS) were significantly shorter in patients expressing high levels of PAI-1 mRNA (p < 0.0001; p < 0.0001; respectively).
Positive_regulation (levels) of Gene_expression (expressing) of PAI-1 mRNA associated with breast cancer and metastasis
10) Confidence 0.46 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1564186 Disease Relevance 0.56 Pain Relevance 0
More recently, Castello et al. [31] developed a quantitative real-time RT-PCR assay and showed that uPA and PAI-1 mRNA expression increased with tumor severity in breast cancer, thereby confirming previous results obtained by Northern blotting [32].
Positive_regulation (increased) of Gene_expression (expression) of PAI-1 mRNA associated with cancer and breast cancer
11) Confidence 0.46 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.67 Pain Relevance 0
Moreover, it has recently been shown that PAI-1 mRNA expression increased with colorectal cancer and the oesophageal squamous carcinoma stage and was associated with poor prognosis suggesting that the gene expression of this marker may serve as a new prognostic factor in these two types of cancer [35,36].


Positive_regulation (increased) of Gene_expression (expression) of PAI-1 mRNA associated with squamous cell carcinoma, cancer and colon cancer
12) Confidence 0.46 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 1.08 Pain Relevance 0
The resulting proteins are secreted and lead to increased expression of plasminogen activator inhibitor-1 (PAI1).
Positive_regulation (lead) of Gene_expression (expression) of plasminogen activator inhibitor-1
13) Confidence 0.45 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.41 Pain Relevance 0
The resulting proteins are secreted and lead to increased expression of plasminogen activator inhibitor-1 (PAI1).
Positive_regulation (increased) of Gene_expression (expression) of plasminogen activator inhibitor-1
14) Confidence 0.45 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.41 Pain Relevance 0
The resulting proteins are secreted and lead to increased expression of plasminogen activator inhibitor-1 (PAI1).
Positive_regulation (lead) of Gene_expression (expression) of PAI1
15) Confidence 0.45 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.41 Pain Relevance 0
The two drugs, at therapeutic concentrations, exerted a stimulatory effect on the synthesis of PAI-1 whereas the synthesis of IL-6 was significantly reduced by both NSAIDs.
Positive_regulation (exerted) of Gene_expression (synthesis) of PAI-1
16) Confidence 0.44 Published 1997 Journal Clin. Exp. Rheumatol. Section Body Doc Link 9272300 Disease Relevance 0.09 Pain Relevance 0
Concentrations of t-PA and PAI-1 were significantly increased in the two groups of diabetics versus controls.


Positive_regulation (increased) of Gene_expression (Concentrations) of PAI-1 associated with diabetes mellitus
17) Confidence 0.37 Published 2008 Journal Vascular Health and Risk Management Section Abstract Doc Link PMC2663449 Disease Relevance 0.85 Pain Relevance 0.04
In diabetics without complications, the plasma levels of PAI-1 and t-PA were elevated to the same extent as in those with complications, whereas the levels of the three other markers were normal.
Positive_regulation (elevated) of Gene_expression (levels) of PAI-1 in plasma associated with diabetes mellitus
18) Confidence 0.37 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 1.03 Pain Relevance 0
Interestingly, the expression levels of TrkB and PAI-1 were elevated in the AD samples.
Positive_regulation (elevated) of Gene_expression (levels) of PAI-1 associated with disease
19) Confidence 0.35 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.74 Pain Relevance 0.58
ACE-I also modulate the vascular fibrinolytic balance by decreasing Ang II, a potent activator of plasminogen activator inhibitor type 1 (PAI-1) synthesis, and by increasing levels of bradykinin, a potent activator for tissue plasminogen (Vaughan 1997).
Positive_regulation (activator) of Gene_expression (synthesis) of plasminogen activator inhibitor type 1 associated with bradykinin
20) Confidence 0.28 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.57 Pain Relevance 0.19

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