INT11636

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Context Info
Confidence 0.69
First Reported 1988
Last Reported 2011
Negated 4
Speculated 1
Reported most in Body
Documents 85
Total Number 86
Disease Relevance 68.73
Pain Relevance 14.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINE1) extracellular region (SERPINE1) plasma membrane (SERPINE1)
Anatomy Link Frequency
plasma 11
endothelial cells 4
Adipose tissue 3
blood 2
hip 2
SERPINE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 734 100.00 Very High Very High Very High
cytokine 179 99.98 Very High Very High Very High
Osteoarthritis 105 99.84 Very High Very High Very High
cocaine 420 99.68 Very High Very High Very High
Angina 136 99.68 Very High Very High Very High
bDMF 42 99.64 Very High Very High Very High
depression 74 99.44 Very High Very High Very High
palliative 10 99.10 Very High Very High Very High
tolerance 90 98.40 Very High Very High Very High
cINOD 18 98.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 865 100.00 Very High Very High Very High
Hypertension 291 100.00 Very High Very High Very High
Adhesions 248 100.00 Very High Very High Very High
Nicotine Addiction 116 100.00 Very High Very High Very High
Hyperuricemia 3 100.00 Very High Very High Very High
Frailty 110 99.84 Very High Very High Very High
Stress 357 99.76 Very High Very High Very High
Polycystic Ovary Syndrome 249 99.70 Very High Very High Very High
Breast Cancer 202 99.70 Very High Very High Very High
Disease 496 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Impaired fibrinolytic function, mainly due to an elevation of plasma plasminogen activator inhibitor 1 concentration, is a common finding in patients with thrombotic disease.
Positive_regulation (elevation) of plasma plasminogen activator in plasma associated with disease
1) Confidence 0.69 Published 1996 Journal Curr. Opin. Hematol. Section Abstract Doc Link 9372104 Disease Relevance 0.45 Pain Relevance 0.08
Increased TAT indicates a procoagulant state, and increased PAI antigen indicates a hypofibrinolytic state.
Positive_regulation (increased) of PAI
2) Confidence 0.67 Published 2006 Journal J. Vasc. Surg. Section Body Doc Link 16414385 Disease Relevance 0 Pain Relevance 0
Two NSAIDs, nimesulide and naproxen, can reduce the synthesis of urokinase and IL-6 while increasing PAI-1, in human OA synovial fibroblasts.
Positive_regulation (increasing) of PAI-1 in fibroblasts associated with cinod
3) Confidence 0.65 Published 1997 Journal Clin. Exp. Rheumatol. Section Title Doc Link 9272300 Disease Relevance 0.09 Pain Relevance 0.33
In patients subjected to hip surgery, preoperatively increased levels of plasminogen activator inhibitor 1 seem to be predictive of postoperative deep venous thrombosis.
Positive_regulation (increased) of activator inhibitor 1 in hip associated with thrombosis related under development
4) Confidence 0.61 Published 1996 Journal Curr. Opin. Hematol. Section Abstract Doc Link 9372104 Disease Relevance 0.52 Pain Relevance 0.09
Increased plasminogen activator inhibitor activity and diabetes predict subsequent coronary events in patients with angina pectoris.
Positive_regulation (Increased) of plasminogen activator associated with angina and diabetes mellitus
5) Confidence 0.59 Published 2001 Journal Ann. Med. Section Title Doc Link 11370775 Disease Relevance 0.29 Pain Relevance 0.18
In the absence of vascular complications, however, only plasma t-PA and PAI-1 levels were significantly increased compared with those in non-diabetic controls.
Positive_regulation (increased) of PAI-1 in plasma associated with diabetes mellitus
6) Confidence 0.55 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663449 Disease Relevance 1.05 Pain Relevance 0.03
However, it is unknown whether the localized concentrations of active PAI-1 necessary to produce this antifibrinolytic effect can be recruited to acute arterial thrombi by endogenous mechanisms.
Positive_regulation (recruited) of PAI-1
7) Confidence 0.50 Published 1996 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 8857925 Disease Relevance 0.14 Pain Relevance 0
Several recent analyses indicated that breast cancer patients with high uPA/PAI-1 protein levels derived a significantly greater benefit from adjuvant chemotherapy than patients with low uPA/PAI-1 contents [10,11].
Positive_regulation (high) of PAI-1 associated with breast cancer
8) Confidence 0.50 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.89 Pain Relevance 0.04
However, despite attaining the of highest level of evidence for clinical application, uPA and PAI-1 are not widely used in clinical practice.
Neg (not) Positive_regulation (used) of PAI-1
9) Confidence 0.50 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.49 Pain Relevance 0.19
However, there was no significant increase in PAI-1 antigen secreted into the culture medium after PMA (100-300 nM) treatment.
Neg (no) Positive_regulation (increase) of PAI-1
10) Confidence 0.49 Published 1994 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7525383 Disease Relevance 0.20 Pain Relevance 0.26
RESULTS: Both on day 0 and day 10, patients with an acute coronary syndrome had a marked elevation of t-PA mass concentration (mean value +/- SEM 14.4 +/- 1.6 [day 0], 18.9 +/- 2.5 ng/ml [day 10]) and of plasminogen activator inhibitor (PAI) (9.4 +/- 2.2 [day 0], 11.3 +/- 2.6 AU/liter [day 10], p < 0.05 vs. patients with stable angina).
Positive_regulation (elevation) of PAI
11) Confidence 0.49 Published 1998 Journal J. Am. Coll. Cardiol. Section Body Doc Link 9502633 Disease Relevance 0.07 Pain Relevance 0
Retrospective analyses of samples from gastric cancer patients have suggested an association with the cagA+/vacA+-positive genotype.33 Further studies have confirmed that a risk for both cancer and peptic ulcer is associated particularly with the cagA/vacA s1m1 genotype, but rarely with strains carrying the vacA s2m2 polymorphism.34,35 However, the cagA gene does not act alone, because delivery of the CagA protein into epithelial cells appears to be dependent on a secretion system encoded for by the adjacent cluster of genes, the cag PAI.36 After the CagA protein is injected into the host cell cytoplasm, it is tyrosine phosphorylated by host Src kinases and subsequently changes the epithelial morphology.37–41 CagA in strains from distinct geographic populations appears to be phosphorylated to a different degree, resulting in graded effects on intracellular signaling.42,43
Positive_regulation (cag) of PAI in epithelial cells associated with cancer, ulcers, sprains and strains and stomach cancer
12) Confidence 0.49 Published 2007 Journal J Gastroenterol Section Body Doc Link PMC2780612 Disease Relevance 0.72 Pain Relevance 0.07
To verify whether the higher expression levels of PAI-1 and COX-2 observed in STs could have been induced by the preceding CB procedure, we compared the expression levels of the same genes in an independent population of 317 primary breast cancer patients.
Positive_regulation (induced) of PAI-1 associated with breast cancer
13) Confidence 0.48 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779463 Disease Relevance 0.37 Pain Relevance 0.11
The study by Moliterno et al demonstrated a statistically significant increase in plasminogen activator inhibitor (PAI-1) after cocaine administration[37].
Positive_regulation (increase) of PAI-1 associated with cocaine
14) Confidence 0.47 Published 2007 Journal Subst Abuse Treat Prev Policy Section Body Doc Link PMC2042971 Disease Relevance 0.38 Pain Relevance 0.33
The link between the production of PAI-1 inducers such as tumor necrosis factor-alpha and transforming growth factor-beta and the production of PAI-1 by adipose tissue was also evaluated.
Positive_regulation (inducers) of PAI-1 in adipose tissue associated with necrosis, cancer and obesity
15) Confidence 0.47 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10323791 Disease Relevance 0.81 Pain Relevance 0.08
Nevertheless, in metastatic breast cancer, retrospective studies showed that elevated uPA or PAI-1 present in the primary tumor are associated with a poor response to later palliative endocrine therapy [14] suggesting that high levels of uPA and/or PAI-1 do reflect an aggressive phenotype that may be overcome by early systemic therapy in the adjuvant setting but not by palliative therapy at a later stage of the disease.
Positive_regulation (levels) of PAI-1 associated with cancer, disease, advanced or metastatic breast cancer and palliative
16) Confidence 0.46 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1564186 Disease Relevance 0.63 Pain Relevance 0.23
Metastasis-free Survival (MFS) and Breast Cancer specific Survival (BCS) were significantly shorter in patients expressing high levels of PAI-1 mRNA (p < 0.0001; p < 0.0001; respectively).
Positive_regulation (levels) of PAI-1 mRNA associated with breast cancer and metastasis
17) Confidence 0.46 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1564186 Disease Relevance 0.56 Pain Relevance 0
We detect the induction of both fibronectin and PAI1 in NHEK cells at both 12 and 24 hrs, suggesting a role of EGR1 pathways in the NAC mediated mechanism at least in this cell type.
Positive_regulation (induction) of PAI1
18) Confidence 0.45 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.43 Pain Relevance 0
Indeed, elevated levels of uPA and PAI-1 are associated with poor clinical outcome in breast cancer and also have predictive value [33-35].
Positive_regulation (elevated) of PAI-1 associated with breast cancer
19) Confidence 0.44 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779463 Disease Relevance 1.39 Pain Relevance 0.16
Plasminogen activator inhibitor-1 (PAI-1), secreted by vascular cells, is the primary physiological inhibitor of plasminogen activation in blood, contributing to thrombus formation [23].
Positive_regulation (activation) of PAI-1 in blood associated with thrombosis
20) Confidence 0.44 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2896837 Disease Relevance 1.49 Pain Relevance 0.15

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