INT116360

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.64
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 4.40
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
cleavage 4
plasma 3
Blood 2
venous system 1
C3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 114 97.76 Very High Very High Very High
anesthesia 4 95.32 Very High Very High Very High
cytokine 4 92.04 High High
antagonist 9 69.92 Quite High
Inflammatory response 20 62.36 Quite High
Pain 13 60.48 Quite High
rheumatoid arthritis 54 49.36 Quite Low
imagery 4 48.72 Quite Low
ischemia 27 5.00 Very Low Very Low Very Low
cva 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 137 97.76 Very High Very High Very High
Targeted Disruption 24 96.72 Very High Very High Very High
Flavivirus Infection 160 96.28 Very High Very High Very High
Cardiovascular Disease 86 93.04 High High
Infection 109 91.04 High High
Skin Ulcer 2 89.60 High High
Eczema 2 88.60 High High
Disease 240 87.24 High High
Death 18 85.04 High High
Edema 10 84.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a significant rise in C5b-9 membrane attack complex (P =.0012) with a corresponding fall in C3 (P =.0013) and C4 (P =.0002) levels and a rise in C3 degradation product levels (P =.0006).
Protein_catabolism (degradation) of C3
1) Confidence 0.64 Published 2004 Journal Liver Transpl. Section Abstract Doc Link 14762866 Disease Relevance 0 Pain Relevance 0.12
Blood was drawn for estimation of C3, C4, C3 degradation product, membrane attack complex, and CH100 levels and elastase (a marker of neutrophil activation) at induction of anesthesia, 5 minutes before reperfusion, 5 minutes and 60 minutes after reperfusion.
Protein_catabolism (degradation) of C3 in Blood associated with anesthesia
2) Confidence 0.64 Published 2004 Journal Liver Transpl. Section Abstract Doc Link 14762866 Disease Relevance 0 Pain Relevance 0.14
Dilution alone cannot explain the fall in C3 and C4 levels as there is a corresponding increase in membrane attack complex and C3 degradation product levels with time.
Protein_catabolism (degradation) of C3
3) Confidence 0.64 Published 2004 Journal Liver Transpl. Section Abstract Doc Link 14762866 Disease Relevance 0 Pain Relevance 0.09
Blood was drawn for estimation of C3, C4, C3 degradation product, membrane attack complex, and CH100 levels and elastase (a marker of neutrophil activation) at induction of anesthesia, 5 minutes before reperfusion, 5 minutes and 60 minutes after reperfusion.
Protein_catabolism (degradation) of C3 in Blood associated with anesthesia
4) Confidence 0.64 Published 2004 Journal Liver Transpl. Section Abstract Doc Link 14762866 Disease Relevance 0 Pain Relevance 0.14
During complement activation, C3 is cleaved to form C3a and C3b; when C3 is cleaved faster than it can be replaced, the levels of intact C3 decay.
Protein_catabolism (cleaved) of C3
5) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.55 Pain Relevance 0
During complement activation, C3 is cleaved to form C3a and C3b; when C3 is cleaved faster than it can be replaced, the levels of intact C3 decay.
Protein_catabolism (cleaved) of C3
6) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.38 Pain Relevance 0
Patients of grades C3 to C6 show an increasing severity of CVI, and all suffer from a functional abnormality of the venous system.
Protein_catabolism (grades) of C3 in venous system
7) Confidence 0.27 Published 2010 Journal Hum Genet Section Body Doc Link PMC2871097 Disease Relevance 0.93 Pain Relevance 0
49) for the CVI phenotype (grades C3 to C6).
Protein_catabolism (grades) of C3
8) Confidence 0.27 Published 2010 Journal Hum Genet Section Body Doc Link PMC2871097 Disease Relevance 0.21 Pain Relevance 0
The alternative pathway (AP) is spontaneously activated by hydrolysis of plasma C3 into C3 (H2O).
Protein_catabolism (hydrolysis) of C3 in plasma
9) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.46 Pain Relevance 0.16
The alternative pathway (AP) is spontaneously activated by hydrolysis of plasma C3 into C3 (H2O).
Protein_catabolism (hydrolysis) of C3 in plasma
10) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.46 Pain Relevance 0.16
This is a stable convertase that continuously cleaves component C3 and C5, leading to depletion of serum complement components [61].
Protein_catabolism (cleaves) of C3
11) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.29 Pain Relevance 0.06
As saliva is a complex mixture of proteins, proteolytic cleavage of C3, as well as other possible additional mechanisms, may also be involved in inhibition of the AP.
Protein_catabolism (cleavage) of C3 in cleavage
12) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
During complement activation by the alternative pathway, plasma protein C3 is cleaved into the large opsonizing factor C3b and the small pro-inflammatory peptide C3a and precursor B is cleaved into a large Bb fragment and a small Ba peptide.
Protein_catabolism (cleaved) of C3 in plasma associated with inflammation
13) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.24 Pain Relevance 0.05
We assessed the effect of recombinant IxAC proteins on the formation and stability of C3 convertase in vitro using the above-described ELISA method. 96-well polystyrene microtiter plates were first coated with 150 ng of C3b per well.
Protein_catabolism (stability) of C3
14) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
To assess the effect of IxACs on the stability of the C3 convertase, C3b-coated wells were incubated for 1 h with 200 ng of factor B, 20 ng of factor D, 200 ng of factor P in sample buffer.
Protein_catabolism (stability) of C3
15) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
Enzyme-linked immunosorbent assays for assessing the effect of IxACs on the formation and stability of C3 convertase
Protein_catabolism (stability) of C3
16) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0 Pain Relevance 0
These bimolecular surface-bound enzyme complexes catalyze the key reaction in complement activation: cleavage of complement protein C3 into C3a, a chemoattractant with bactericidal activity [2–4], and C3b [5].
Protein_catabolism (cleavage) of C3 in cleavage
17) Confidence 0.14 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.13 Pain Relevance 0.03
Cleavage of C3
Protein_catabolism (Cleavage) of C3 in Cleavage
18) Confidence 0.14 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.25 Pain Relevance 0
IxACs inhibit the cleavage of human C3 and factor B
Protein_catabolism (cleavage) of C3 in cleavage
19) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.24 Pain Relevance 0.04
The abundant GAS protease SpeB is, next to cleaving IgG, involved in breakdown of C3.
Protein_catabolism (breakdown) of C3
20) Confidence 0.12 Published 2010 Journal J Mol Med Section Body Doc Link PMC2832872 Disease Relevance 0.26 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox