INT116361

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Context Info
Confidence 0.45
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.86
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (C3) extracellular space (C3) extracellular region (C3)
Anatomy Link Frequency
plasma 4
venous system 2
C3 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 3 91.16 High High
Inflammation 20 77.84 Quite High
cytokine 3 77.24 Quite High
Inflammatory response 4 62.88 Quite High
Pain 3 61.00 Quite High
imagery 2 50.72 Quite High
rheumatoid arthritis 12 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
psoriasis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cardiovascular Disease 43 89.84 High High
Skin Ulcer 1 89.60 High High
Eczema 1 88.60 High High
Disease 61 87.24 High High
Death 4 85.56 High High
Edema 5 84.76 Quite High
Increased Venous Pressure Under Development 17 84.28 Quite High
Telangiectasia 2 83.68 Quite High
INFLAMMATION 24 77.84 Quite High
Pruritus 2 61.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dilution alone cannot explain the fall in C3 and C4 levels as there is a corresponding increase in membrane attack complex and C3 degradation product levels with time.
Positive_regulation (increase) of Protein_catabolism (degradation) of C3
1) Confidence 0.45 Published 2004 Journal Liver Transpl. Section Abstract Doc Link 14762866 Disease Relevance 0 Pain Relevance 0.09
There was a significant rise in C5b-9 membrane attack complex (P =.0012) with a corresponding fall in C3 (P =.0013) and C4 (P =.0002) levels and a rise in C3 degradation product levels (P =.0006).
Positive_regulation (rise) of Protein_catabolism (degradation) of C3
2) Confidence 0.45 Published 2004 Journal Liver Transpl. Section Abstract Doc Link 14762866 Disease Relevance 0 Pain Relevance 0.12
There was a significant rise in C5b-9 membrane attack complex (P =.0012) with a corresponding fall in C3 (P =.0013) and C4 (P =.0002) levels and a rise in C3 degradation product levels (P =.0006).
Positive_regulation (rise) of Protein_catabolism (degradation) of C3
3) Confidence 0.45 Published 2004 Journal Liver Transpl. Section Abstract Doc Link 14762866 Disease Relevance 0 Pain Relevance 0.13
Patients of grades C3 to C6 show an increasing severity of CVI, and all suffer from a functional abnormality of the venous system.
Positive_regulation (increasing) of Protein_catabolism (grades) of C3 in venous system
4) Confidence 0.14 Published 2010 Journal Hum Genet Section Body Doc Link PMC2871097 Disease Relevance 0.93 Pain Relevance 0.03
The alternative pathway (AP) is spontaneously activated by hydrolysis of plasma C3 into C3 (H2O).
Positive_regulation (activated) of Protein_catabolism (hydrolysis) of C3 in plasma
5) Confidence 0.11 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.46 Pain Relevance 0.16
The alternative pathway (AP) is spontaneously activated by hydrolysis of plasma C3 into C3 (H2O).
Positive_regulation (activated) of Protein_catabolism (hydrolysis) of C3 in plasma
6) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2151134 Disease Relevance 0.46 Pain Relevance 0.16

General Comments

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