INT116362

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 11.53
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C4A) extracellular region (C4A)
Anatomy Link Frequency
B-cell 3
C4A (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 4 99.36 Very High Very High Very High
analgesia 3 95.52 Very High Very High Very High
Pain 13 75.00 Quite High
Versed 5 75.00 Quite High
visual analogue scale 16 72.52 Quite High
fibrosis 3 71.72 Quite High
anesthesia 1 67.16 Quite High
headache 8 62.24 Quite High
cytokine 1 53.24 Quite High
Sicca syndrome 14 50.00 Quite Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 31 100.00 Very High Very High Very High
Lymphoproliferative Disease 20 99.40 Very High Very High Very High
Malignant Neoplastic Disease 18 98.12 Very High Very High Very High
Cryoglobulinemia 438 97.80 Very High Very High Very High
Hereditary Angioedema 186 97.76 Very High Very High Very High
Flavivirus Infection 160 97.56 Very High Very High Very High
Dengue 208 97.40 Very High Very High Very High
Lymphatic System Cancer 51 96.52 Very High Very High Very High
Disease 186 95.60 Very High Very High Very High
Syndrome 145 94.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A subset of the patients with severely delayed OATT had markedly elevated C4 levels.
Positive_regulation (elevated) of C4
1) Confidence 0.69 Published 2008 Journal Scand. J. Gastroenterol. Section Body Doc Link 18788050 Disease Relevance 0.06 Pain Relevance 0
0.002) and increased levels of C3a, C4a and C5a (p<0.0001) when compared to those with the less severe form, DF.
Positive_regulation (increased) of C4a associated with dengue
2) Confidence 0.49 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2728508 Disease Relevance 1.12 Pain Relevance 0
The incidence of shivering was significantly increased in group M compared to group C 2 and C 4 .
Positive_regulation (increased) of C 4
3) Confidence 0.49 Published 2009 Journal Biosci Trends Section Abstract Doc Link 20103833 Disease Relevance 0.40 Pain Relevance 0.77
The LP could also potentially play a role, leading to elevated levels of C4a.
Positive_regulation (elevated) of C4a
4) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728508 Disease Relevance 0.89 Pain Relevance 0
Dilution alone cannot explain the fall in C3 and C4 levels as there is a corresponding increase in membrane attack complex and C3 degradation product levels with time.
Positive_regulation (increase) of C4
5) Confidence 0.42 Published 2004 Journal Liver Transpl. Section Abstract Doc Link 14762866 Disease Relevance 0 Pain Relevance 0.09
When constipated patients were categorized according to OATT, absence of the usual C4 increase at lunchtime was noted in 82% of patients with delayed OATT compared with 17% in subjects with normal OATT (p <0.001).
Positive_regulation (increase) of C4
6) Confidence 0.40 Published 2008 Journal Scand. J. Gastroenterol. Section Body Doc Link 18788050 Disease Relevance 0.07 Pain Relevance 0
C4 gene copy number varies from two to six for total C4, zero to five for C4A, and zero to four for C4B.
Positive_regulation (varies) of C4
7) Confidence 0.37 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC2039766 Disease Relevance 0.87 Pain Relevance 0
Compared with healthy subjects, patients with SLE clearly have lower copy numbers of C4 and C4A, and SLE susceptibility is significantly increased among subjects with only two copies of total C4 but decreased in those with more than five copies of C4 [68].
Positive_regulation (increased) of C4 associated with systemic lupus erythematosus
8) Confidence 0.28 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC2039766 Disease Relevance 0.85 Pain Relevance 0
Compared with healthy subjects, patients with SLE clearly have lower copy numbers of C4 and C4A, and SLE susceptibility is significantly increased among subjects with only two copies of total C4 but decreased in those with more than five copies of C4 [68].
Positive_regulation (increased) of C4A associated with systemic lupus erythematosus
9) Confidence 0.28 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC2039766 Disease Relevance 0.85 Pain Relevance 0
In this case the surface patch generated as a solution to the fourth order PDE contains the boundary curves c1 and c4 whilst it does not necessarily contain the curves c2 and c3.
Positive_regulation (curves) of c4
10) Confidence 0.24 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1198260 Disease Relevance 0 Pain Relevance 0
Of interest, a sudden increase in C4, raised to abnormally high levels, can be observed in MC patients developing a B-cell lymphoma [45].
Positive_regulation (increase) of C4 in B-cell associated with cryoglobulinemia and lymphatic system cancer
11) Confidence 0.09 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2569912 Disease Relevance 1.33 Pain Relevance 0.04
On the contrary, a sudden decrease or disappearance of serum mixed cryoglobulins, with or without abnormally high levels of C4, can be regarded as alarming signal of complicating B-cell malignancy [45].
Neg (without) Positive_regulation (levels) of C4 in B-cell associated with malignant neoplastic disease
12) Confidence 0.07 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2569912 Disease Relevance 0.89 Pain Relevance 0
This is consistent with the observations that C4 levels peak several hours after C1-INH levels and remain elevated for a longer period of time, demonstrating a biochemical effect that exceeds the serum half-life of C1-INH levels.
Positive_regulation (elevated) of C4
13) Confidence 0.07 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621399 Disease Relevance 0.22 Pain Relevance 0
Gadek et al demonstrated that C1-INH levels peaked rapidly and dropped quickly; however, C4 levels peaked approximately 6 hours after the C1-INH levels, and the C4 levels remained elevated for a much longer period of time.
Positive_regulation (elevated) of C4
14) Confidence 0.07 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621399 Disease Relevance 0.58 Pain Relevance 0
It is possible to observe a sudden decrease or disappearance of serum cryoglobulins and RF, sometimes associated with abnormally high levels of C4, as presenting symptom of complicating B-cell malignancy [40].
Positive_regulation (levels) of C4 in B-cell associated with malignant neoplastic disease
15) Confidence 0.06 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2569912 Disease Relevance 1.87 Pain Relevance 0
They also noted that serum C4 concentrations remained elevated much longer than C1-INH levels – staying at peak levels at least 24 hours post C1-INH infusion.
Positive_regulation (elevated) of C4
16) Confidence 0.05 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621399 Disease Relevance 0.83 Pain Relevance 0.06
As a low level of C4 has been associated with an increased risk of developing lymphoproliferative disease [25] and as our data show an increase of C3 and C4 levels in patients treated with MPS, this drug may be essentially beneficial in this context.
Positive_regulation (increase) of C4 associated with lymphoproliferative disease
17) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246233 Disease Relevance 0.59 Pain Relevance 0
A significant increase of both C3 and C4 complement levels occurred during the treatment.
Positive_regulation (increase) of C4
18) Confidence 0.04 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246233 Disease Relevance 0.11 Pain Relevance 0.07

General Comments

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