INT116366

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Context Info
Confidence 0.36
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.54
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (P2rx3) Golgi apparatus (P2rx3)
Anatomy Link Frequency
DRG 1
P2rx3 (Mus musculus)
Pain Link Frequency Relevance Heat
c fibre 1 96.36 Very High Very High Very High
Calcitonin gene-related peptide 6 95.24 Very High Very High Very High
Potency 6 94.52 High High
Pain 38 76.48 Quite High
agonist 20 74.96 Quite High
Migraine 36 69.12 Quite High
headache 14 68.40 Quite High
Trigeminal ganglion neurons 10 55.20 Quite High
depression 14 53.84 Quite High
spastic colon 1 52.80 Quite High
Disease Link Frequency Relevance Heat
Pain 40 76.48 Quite High
Migraine Disorders 26 69.12 Quite High
Disease 3 62.40 Quite High
Ganglion Cysts 22 54.88 Quite High
Depression 14 53.84 Quite High
Functional Bowel Disorder 1 52.80 Quite High
Migraine With Aura 10 50.00 Quite Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 46.48 Quite Low
Nociception 6 31.88 Quite Low
Headache 6 9.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to the general DRG population, a subset of neurones exist that are P2X3 receptor-LI but do not bind IB4.
P2X3 Neg (not) Binding (bind) of in DRG
1) Confidence 0.36 Published 2004 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 14764211 Disease Relevance 0.11 Pain Relevance 0.36
Other parameters of P2X3 receptor function, such as current rise-time (?
P2X3 Binding (receptor) of
2) Confidence 0.34 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.17 Pain Relevance 0.26
Even though the structure of the P2X4 receptor in its closed state has been recently reported [49], the numerous serine residues in the N- and C-terminal domains of the P2X3 receptor make it difficult to predict those responsible for binding and catalytic activity of kinases and phosphatases.
P2X3 Binding (binding) of
3) Confidence 0.33 Published 2010 Journal Mol Pain Section Body Doc Link PMC2940876 Disease Relevance 0.26 Pain Relevance 0.24

General Comments

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