INT116376

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Context Info
Confidence 0.40
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 6
Disease Relevance 0.74
Pain Relevance 3.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cyp19a1) endoplasmic reticulum (Cyp19a1) cytoplasm (Cyp19a1)
Anatomy Link Frequency
brain 1
uterine 1
gonads 1
Cyp19a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 265 98.20 Very High Very High Very High
Analgesic 10 90.24 High High
Lasting pain 5 85.72 High High
Pain 95 79.28 Quite High
Opioid 30 78.44 Quite High
opioid receptor 10 74.08 Quite High
Dismenorea 1 70.72 Quite High
metalloproteinase 1 46.40 Quite Low
opiate 10 5.00 Very Low Very Low Very Low
Hippocampus 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 100 85.72 High High
Cognitive Disorder 15 79.12 Quite High
Dysmenorrhea 1 70.72 Quite High
Injury 3 62.24 Quite High
Anaemia 5 29.52 Quite Low
Fatigue 5 29.20 Quite Low
Stress 10 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low
Inflammatory Pain 5 5.00 Very Low Very Low Very Low
Reprotox - General 2 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
mRNA levels for 5-alpha reductase and P450-aromatase (Ct) were normalized to cyclophilin by subtracting the Ct value of the reference gene (cyclophilin) from the Ct value of the samples (?
Transcription (levels) of P450-aromatase
1) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0 Pain Relevance 0
5-alpha reductase (5aR-1) and aromatase (AROM) mRNA expression
Transcription (expression) of aromatase
2) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.07 Pain Relevance 0.46
In this experiment we study the mRNA expression of 5-alpha reductase type 1 (5aR-1) and p450-aromatase (AROM).
Transcription (expression) of p450-aromatase
3) Confidence 0.34 Published 2010 Journal Mol Pain Section Body Doc Link PMC2978140 Disease Relevance 0.21 Pain Relevance 0.45
In the morphine-treated rats, there were increases of 5-alpha reductase mRNA expression in the liver and aromatase mRNA expression in the brain and gonads.
Transcription (expression) of aromatase in brain associated with morphine
4) Confidence 0.34 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2978140 Disease Relevance 0.16 Pain Relevance 1.03
This study examines the effects of the aromatase inhibitor, fadrozole hydrochloride (Fad), on fetuses, uterine physical properties and the mRNA expression of the uterine enzymes that are related to collagen metabolism during late pregnancy in rats.
Transcription (expression) of aromatase in uterine
5) Confidence 0.30 Published 2004 Journal J. Endocrinol. Section Abstract Doc Link 14765986 Disease Relevance 0.13 Pain Relevance 0.07
In the morphine-treated rats, there were increases of 5-alpha reductase mRNA expression in the liver and aromatase mRNA expression in the brain and gonads.
Transcription (expression) of aromatase in gonads associated with morphine
6) Confidence 0.12 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2978140 Disease Relevance 0.16 Pain Relevance 1.03

General Comments

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