INT116402

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Context Info
Confidence 0.24
First Reported 2003
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.78
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
IB4 4
neurons 2
RT1-M4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 7 99.80 Very High Very High Very High
dorsal root ganglion 5 98.16 Very High Very High Very High
Spinal cord 4 92.72 High High
c fibre 4 92.72 High High
substance P 3 91.60 High High
nociceptor 8 90.96 High High
Dorsal horn 3 90.72 High High
Sciatic nerve 3 79.76 Quite High
peripheral neuropathy 1 78.76 Quite High
allodynia 2 77.52 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 4 99.70 Very High Very High Very High
Nociception 6 98.88 Very High Very High Very High
Ganglion Cysts 6 97.68 Very High Very High Very High
Nervous System Injury 5 80.04 Quite High
Peripheral Neuropathy 1 78.76 Quite High
Injury 2 77.56 Quite High
Shock 2 76.76 Quite High
Hypersensitivity 1 59.20 Quite High
Neuropathic Pain 3 54.80 Quite High
Hyperalgesia 1 47.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the central boutons of type Ia represent varicosities from the fibers which bind IB4, the ultrastructural changes confirmed that there was a bona fide transient loss of varicosities, not simply a loss of IB4 binding.
Negative_regulation (loss) of IB4 Binding (binding) of in IB4 associated with increased venous pressure under development
1) Confidence 0.24 Published 2006 Journal Neuroscience Section Abstract Doc Link 16413131 Disease Relevance 0.79 Pain Relevance 0.58
Binding to isolectin-B4 (IB4) and expression of tyrosine kinase A (trkA) (the high-affinity NGF receptor) have been used to define two different subgroups of nociceptive small dorsal root ganglion (DRG) neurons.
Negative_regulation (define) of IB4 Binding (Binding) of in neurons associated with ganglion cysts, nociception and dorsal root ganglion
2) Confidence 0.05 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16822986 Disease Relevance 0.43 Pain Relevance 0.65
In vehicle-treated rats there is a decrease in IB4 binding and CGRP expression in injured neurones, while in BRX-220-treated rats these markers were better preserved.
Negative_regulation (decrease) of IB4 Binding (binding) of in IB4 associated with calcitonin gene-related peptide
3) Confidence 0.01 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14769355 Disease Relevance 0.56 Pain Relevance 0.54

General Comments

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