INT116419

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Context Info
Confidence 0.01
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.58
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Elane) cytoplasm (Elane)
Anatomy Link Frequency
smooth muscle 4
Elane (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 2 95.16 Very High Very High Very High
Clonidine 53 91.08 High High
agonist 7 90.08 High High
Central nervous system 3 87.80 High High
Calcium channel 6 86.96 High High
adenocard 2 82.52 Quite High
Action potential 2 77.80 Quite High
antagonist 8 67.92 Quite High
conotoxin 6 66.20 Quite High
Kinase C 114 63.92 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 1 98.78 Very High Very High Very High
Hypertension 5 88.44 High High
Increased Venous Pressure Under Development 20 67.52 Quite High
Overdose 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of pertussis toxin (a potent inhibitor of the Gi-protein) attenuated the suppression of NE release by UK 14, 304.
Negative_regulation (suppression) of Localization (release) of NE associated with bordatella infection
1) Confidence 0.01 Published 2003 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 14871035 Disease Relevance 0.41 Pain Relevance 0.39
Therefore, none of these agents reduced the EFS-evoked overflow of NE, indicating that their effects on the EFS-induced SMD are not due to inhibited NE release but to activation of postjunctional (i.e., smooth muscle) mechanisms.


Negative_regulation (inhibited) of Localization (release) of NE in smooth muscle
2) Confidence 0.01 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0.12 Pain Relevance 0.27
None of the channel blockers reduced the release of NE thus demonstrating that the decrease of SMD is mediated by postjunctional smooth muscle mechanisms.
Negative_regulation (reduced) of Localization (release) of NE in smooth muscle
3) Confidence 0.01 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0.05 Pain Relevance 0.16

General Comments

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