INT116420

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Context Info
Confidence 0.14
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 20
Disease Relevance 7.80
Pain Relevance 6.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Elane) cytoplasm (Elane)
Anatomy Link Frequency
amygdala 3
lung 3
neutrophil 3
smooth muscle 2
hippocampus 1
Elane (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 190 100.00 Very High Very High Very High
Neurotransmitter 31 100.00 Very High Very High Very High
amygdala 155 99.68 Very High Very High Very High
Hippocampus 60 99.68 Very High Very High Very High
Inflammation 448 98.36 Very High Very High Very High
long-term potentiation 210 97.44 Very High Very High Very High
Kinase C 399 97.08 Very High Very High Very High
Locus ceruleus 40 95.64 Very High Very High Very High
Clonidine 183 94.76 High High
medulla 7 94.56 High High
Disease Link Frequency Relevance Heat
Pulmonary Emphysema 22 99.72 Very High Very High Very High
Increased Venous Pressure Under Development 70 99.32 Very High Very High Very High
Bordatella Infection 1 98.48 Very High Very High Very High
INFLAMMATION 429 98.36 Very High Very High Very High
Pulmonary Disease 640 97.72 Very High Very High Very High
Emphysema 72 96.52 Very High Very High Very High
Toxicity 2 95.20 Very High Very High Very High
Anxiety Disorder 135 91.80 High High
Depression 40 87.96 High High
Hypertension 9 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Active forms of NE, MMP-8, and MMP-9 released from these cells are detectable in lung secretions from COPD patients (Burnett et al 1987; Yoshioka et al 1995; Betsuyaku et al 1999; Hill et al 1999).
Localization (released) of NE in lung associated with pulmonary disease
1) Confidence 0.14 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.94 Pain Relevance 0.14
They localized NE bound to lung elastic fibers and showed that the amount of NE bound to lung elastin is strongly correlated with the degree of emphysematous change.
Localization (localized) of NE in lung
2) Confidence 0.13 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 1.09 Pain Relevance 0.15
Active forms of NE, MMP-8, and MMP-9 released from these cells are detectable in lung secretions from COPD patients (Burnett et al 1987; Yoshioka et al 1995; Betsuyaku et al 1999; Hill et al 1999).
Localization (released) of NE in lung associated with pulmonary disease
3) Confidence 0.13 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.94 Pain Relevance 0.14
Targeted deletion of neutrophil elastase or MMP-12 protects from the development of cigarette smoke or gp91 deficiency-induced emphysema (Hautamaki et al 1997; Shapiro et al 2003; Kassim et al 2005).
Localization (deletion) of neutrophil elastase in neutrophil associated with emphysema and metalloproteinase
4) Confidence 0.12 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.81 Pain Relevance 0.15
Neutrophil elastase is a serine protease that is synthesized in the neutrophils and secreted following neutrophils activation.
Localization (secreted) of Neutrophil elastase in neutrophils
5) Confidence 0.12 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.08 Pain Relevance 0.24
Thus, the oxidative burst is a prerequisite for the mobilization of cationic neutrophil elastase and cathepsin G, which are stored in granules complexed with the strongly anionic sulfated proteoglycan matrix.
Localization (mobilization) of neutrophil elastase in neutrophil
6) Confidence 0.06 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1522038 Disease Relevance 0.44 Pain Relevance 0
NE, MMP-12, and MMP-9 cleave elastin, and MMPs cleave ?
Localization (cleave) of NE associated with metalloproteinase
7) Confidence 0.06 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 0.74 Pain Relevance 0.35
Pretreatment of pertussis toxin (a potent inhibitor of the Gi-protein) attenuated the suppression of NE release by UK 14, 304.
Localization (release) of NE associated with bordatella infection
8) Confidence 0.02 Published 2003 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 14871035 Disease Relevance 0.41 Pain Relevance 0.39
Therefore, none of these agents reduced the EFS-evoked overflow of NE, indicating that their effects on the EFS-induced SMD are not due to inhibited NE release but to activation of postjunctional (i.e., smooth muscle) mechanisms.


Localization (release) of NE in smooth muscle
9) Confidence 0.02 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0.12 Pain Relevance 0.27
Norepinephrine (NE), a classic neurotransmitter in the sympathetic nervous system, is released from adrenergic varicosities of stimulated postganglionic nerve terminals, activates postjunctional ?
Localization (released) of NE in sympathetic nervous system associated with neurotransmitter and increased venous pressure under development
10) Confidence 0.02 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0.19 Pain Relevance 0.05
Author VM-Y participated in the membrane potential, NE release and mechanical activity experiments and designed and coordinated the study.
Localization (release) of NE
11) Confidence 0.02 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0 Pain Relevance 0.16
None of the channel blockers reduced the release of NE thus demonstrating that the decrease of SMD is mediated by postjunctional smooth muscle mechanisms.
Localization (release) of NE in smooth muscle
12) Confidence 0.02 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0.05 Pain Relevance 0.16
To test this possibility, we assayed the EFS-evoked release of NE in superfusates collected during EFS in control veins and in tissues preincubated with each of the aforementioned blockers.
Localization (release) of NE in veins
13) Confidence 0.02 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0 Pain Relevance 0.61
2-adrenoreceptors may be involved in the membrane potential changes in response to NE that is released upon EFS.


Localization (released) of NE
14) Confidence 0.02 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0.16 Pain Relevance 0.40
In this study we provide functional and biochemical evidence that NE, released from postganglionic nerve terminals, activates postjunctional ?
Localization (released) of NE in nerve
15) Confidence 0.02 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0.06 Pain Relevance 0.50
The release of NE in the hippocampus during emotionally-charged events could thus modulate the hippocampus-dependent forms of memory by controlling the induction of synaptic plasticity at corresponding synapses in hippocampal neuronal circuits.


Localization (release) of NE in neuronal associated with hippocampus
16) Confidence 0.02 Published 2010 Journal Mol Brain Section Body Doc Link PMC2877027 Disease Relevance 0.31 Pain Relevance 0.56
Moreover, the amount of NE released in the amygdala during inhibitory avoidance training correlated strongly with 24-h retention performance [43].
Localization (released) of NE in amygdala associated with amygdala
17) Confidence 0.02 Published 2010 Journal Mol Brain Section Body Doc Link PMC2877027 Disease Relevance 0.15 Pain Relevance 0.45
Using labeled norepinephrine, it was directly demonstrated that NE could be released in the hippocampus in an activity-dependent fashion.
Localization (released) of NE in hippocampus associated with hippocampus
18) Confidence 0.02 Published 2010 Journal Mol Brain Section Body Doc Link PMC2877027 Disease Relevance 0.15 Pain Relevance 0.63
In experiments using in vivo microdialysis and high-performance liquid chromatography (HPLC), NE release in the rat amygdala was detected in response to footshock stimulation which is usually used in inhibitory avoidance training paradigm [39].
Localization (release) of NE in amygdala associated with amygdala
19) Confidence 0.02 Published 2010 Journal Mol Brain Section Body Doc Link PMC2877027 Disease Relevance 0 Pain Relevance 0.26
These findings were consistent with the notion that NE released by arousing stimulation could be involved in the functional regulation of neural circuits in the amygdala.
Localization (released) of NE in amygdala associated with amygdala
20) Confidence 0.02 Published 2010 Journal Mol Brain Section Body Doc Link PMC2877027 Disease Relevance 0.13 Pain Relevance 0.40

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