INT116425

Context Info Confidence 0.78 First Reported 2004 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 0.63 Pain Relevance 0

signal transduction (EPO) extracellular space (EPO) aging (EPO) extracellular region (EPO)

EPO (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 8 45.52 Pain 1 25.00 headache 6 5.00 ischemia 2 5.00 Glutamate 2 5.00

Disease Link Frequency Relevance Heat Hypersensitivity 10 97.84 Anaemia 9 88.80 Cancer 10 75.00 Solid Tumor 3 68.16 Erythrocytosis 22 50.00 Hyperplasia 2 26.12 Hypertension 3 25.00 Reprotox - General 1 1 25.00 Pain 1 25.00 Myelodysplastic Syndromes 30 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

As shown in Figure 5A, transfection of the truncated receptor induced a number of biochemical changes (i.e. receptor autophosphorylation and STAT5 phosphorylation), even in the absence of exogenously added EPO, suggesting the possibility of autoactivation and/or hypersensitivity of receptor.

Phosphorylation (phosphorylation) of EPO associated with hypersensitivity

1) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.10 Pain Relevance 0

As shown in Figure 5A, transfection of the truncated receptor induced a number of biochemical changes (i.e. receptor autophosphorylation and STAT5 phosphorylation), even in the absence of exogenously added EPO, suggesting the possibility of autoactivation and/or hypersensitivity of receptor.

Phosphorylation (autophosphorylation) of EPO associated with hypersensitivity

2) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.10 Pain Relevance 0

Epoetin beta (NeoRecormon) is a recombinant form of erythropoietin.

Phosphorylation (form) of erythropoietin

3) Confidence 0.55 Published 2004 Journal Drugs Section Abstract Doc Link 14871172 Disease Relevance 0.43 Pain Relevance 0

General Comments

This test has worked.