INT116425

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.63
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EPO) extracellular space (EPO) aging (EPO)
extracellular region (EPO)
EPO (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 45.52 Quite Low
Pain 1 25.00 Low Low
headache 6 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 10 97.84 Very High Very High Very High
Anaemia 9 88.80 High High
Cancer 10 75.00 Quite High
Solid Tumor 3 68.16 Quite High
Erythrocytosis 22 50.00 Quite Low
Hyperplasia 2 26.12 Quite Low
Hypertension 3 25.00 Low Low
Reprotox - General 1 1 25.00 Low Low
Pain 1 25.00 Low Low
Myelodysplastic Syndromes 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As shown in Figure 5A, transfection of the truncated receptor induced a number of biochemical changes (i.e. receptor autophosphorylation and STAT5 phosphorylation), even in the absence of exogenously added EPO, suggesting the possibility of autoactivation and/or hypersensitivity of receptor.
Phosphorylation (phosphorylation) of EPO associated with hypersensitivity
1) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.10 Pain Relevance 0
As shown in Figure 5A, transfection of the truncated receptor induced a number of biochemical changes (i.e. receptor autophosphorylation and STAT5 phosphorylation), even in the absence of exogenously added EPO, suggesting the possibility of autoactivation and/or hypersensitivity of receptor.
Phosphorylation (autophosphorylation) of EPO associated with hypersensitivity
2) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916842 Disease Relevance 0.10 Pain Relevance 0
Epoetin beta (NeoRecormon) is a recombinant form of erythropoietin.
Phosphorylation (form) of erythropoietin
3) Confidence 0.55 Published 2004 Journal Drugs Section Abstract Doc Link 14871172 Disease Relevance 0.43 Pain Relevance 0

General Comments

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