INT116426

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Context Info
Confidence 0.58
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.75
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pdpn) signal transduction (Pdpn) cell morphogenesis (Pdpn)
cell adhesion (Pdpn) plasma membrane (Pdpn) cell cycle (Pdpn)
Anatomy Link Frequency
stroma 2
Pdpn (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 4 76.36 Quite High
Pain 5 75.00 Quite High
diabetic neuropathy 2 75.00 Quite High
anesthesia 8 58.40 Quite High
ketamine 8 57.12 Quite High
Inflammation 21 47.80 Quite Low
antagonist 15 47.60 Quite Low
Osteoarthritis 9 36.24 Quite Low
Shingles 1 28.24 Quite Low
methotrexate 1 17.52 Low Low
Disease Link Frequency Relevance Heat
Herpes Zoster 20 99.56 Very High Very High Very High
Diabetes Mellitus 9 97.56 Very High Very High Very High
Herpes Simplex Virus 1 96.56 Very High Very High Very High
Disease 38 92.32 High High
Infection 2 75.24 Quite High
Peripheral Neuropathy 2 75.00 Quite High
Rheumatoid Arthritis 139 67.80 Quite High
General Immunology 4 54.00 Quite High
Pain 2 53.52 Quite High
INFLAMMATION 22 48.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using the validated algorithm, pDPN prevalence was 113 (Method 1) and 208 (Method 2) per 1000 persons with diabetes.
Gene_expression (prevalence) of pDPN associated with diabetes mellitus
1) Confidence 0.58 Published 2008 Journal Population health management Section Abstract Doc Link 19108647 Disease Relevance 0.68 Pain Relevance 0.11
and expressed gp38.
Gene_expression (expressed) of gp38
2) Confidence 0.28 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571923 Disease Relevance 0 Pain Relevance 0.04
(RmCD8-2), anti-B220 (TIB146), anti-CCR9 (7E7), and anti-gp38 (8.1.1) antibodies were produced in our laboratory.
Gene_expression (produced) of gp38
3) Confidence 0.22 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571923 Disease Relevance 0.05 Pain Relevance 0.09
Fluorescent microscopy on T cell zones in Tx-LN revealed that EGFP expression colocalized with gp38 (Fig. 1 C) and ER-TR7 (Fig. 1 D), which are both expressed by LN stroma cells, whereas EGFP+ cells showed no overlap with anti-B220 and anti-CD3 staining (not depicted).
Gene_expression (expressed) of gp38 in stroma
4) Confidence 0.22 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571923 Disease Relevance 0.17 Pain Relevance 0
Fluorescent microscopy on T cell zones in Tx-LN revealed that EGFP expression colocalized with gp38 (Fig. 1 C) and ER-TR7 (Fig. 1 D), which are both expressed by LN stroma cells, whereas EGFP+ cells showed no overlap with anti-B220 and anti-CD3 staining (not depicted).
Gene_expression (expression) of gp38 in stroma
5) Confidence 0.22 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571923 Disease Relevance 0.17 Pain Relevance 0
The varicella zoster virus major envelope glycoprotein gE was detected in 16 of 18 smears and all four biopsies.
Gene_expression (detected) of glycoprotein gE associated with herpes zoster
6) Confidence 0.02 Published 2004 Journal Pediatr Dermatol Section Abstract Doc Link 14871320 Disease Relevance 1.68 Pain Relevance 0.05
Double lymphatic and CD31 labeling was performed by simultaneous podoplanin immunoperoxidase and CD31 immunofluorescent detection as indicated above.
Gene_expression (detection) of podoplanin immunoperoxidase
7) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779850 Disease Relevance 0 Pain Relevance 0

General Comments

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