INT116427

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Context Info
Confidence 0.31
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.72
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Smcp) cytoplasm (Smcp)
Anatomy Link Frequency
capsule 3
synovial fluid 1
keratinocyte 1
Smcp (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 102 99.76 Very High Very High Very High
Inflammation 41 92.12 High High
metalloproteinase 2 62.72 Quite High
Glutamate 7 60.88 Quite High
neuropeptide release 32 52.24 Quite High
chemokine 29 48.40 Quite Low
Osteoarthritis 50 45.00 Quite Low
cytokine 15 33.20 Quite Low
Neuropeptide 32 9.92 Low Low
Neurotransmitter 20 9.20 Low Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 110 99.76 Very High Very High Very High
Apoptosis 57 98.52 Very High Very High Very High
Sprains And Strains 76 92.28 High High
INFLAMMATION 41 92.12 High High
Targeted Disruption 8 90.32 High High
Hyperplasia 27 84.20 Quite High
Infection 40 83.48 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 83.04 Quite High
Merkel Cell Carcinoma 12 77.08 Quite High
Infertility 3 74.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of note, co-incubation with pan-caspase inhibitor zVAD-fmk abrogated the inhibitory effect of anti-MCSP:TRAIL on colony outgrowth (Figure 2D), suggesting that apoptotic signaling is required for the inhibitory effect of anti-MCSP:TRAIL.
Negative_regulation (effect) of anti-MCSP associated with apoptosis
1) Confidence 0.31 Published 2010 Journal Mol Cancer Section Body Doc Link PMC3000402 Disease Relevance 0.21 Pain Relevance 0
Compared to FACS selection, we achieved a lower ratio of MCs in our cultures (60–65% versus 85–95%), but a higher number of MCs per animal.
Negative_regulation (number) of MCs
2) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722079 Disease Relevance 0.28 Pain Relevance 0
In these cultures, MCs were difficult to maintain for more than two weeks, they did not undergo mitosis and the low number of MCs restricted the opportunities for analysis [7], [18], [51].
Negative_regulation (number) of MCs
3) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722079 Disease Relevance 0.09 Pain Relevance 0.03
Furthermore, this culture method led to a rapid decrease in the proportion of MCs due to keratinocyte proliferation.
Negative_regulation (decrease) of MCs in keratinocyte
4) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722079 Disease Relevance 0.43 Pain Relevance 0.03
Also, NT-3 appears not to be essential for the development of MCs, but its absence leads to perinatal apoptosis of MCs [54].
Negative_regulation (development) of MCs associated with apoptosis
5) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722079 Disease Relevance 0.33 Pain Relevance 0
Indeed, apart from macrophages, lymphocytes, fibroblasts and neutrophils, which are considered to be important contributors to the pathogenesis of RA, increased numbers of MCs are found in the synovial tissue and synovial fluid of RA patients [44,45].
Negative_regulation (numbers) of MCs in synovial fluid associated with rheumatoid arthritis
6) Confidence 0.14 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193722 Disease Relevance 0.65 Pain Relevance 0.32
Screening mutants for reduced capsule and identification of the transposon insertion site
Negative_regulation (reduced) of capsule in capsule
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897883 Disease Relevance 0.07 Pain Relevance 0
Sandstrom used acridine orange mutagenesis to create a mutant library which was screened for "rough" colonies on solid media; the “rough” colonies were designated as lacking capsule.
Negative_regulation (lacking) of capsule in capsule
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897883 Disease Relevance 0.41 Pain Relevance 0.03
In group 1 the capsule repeats tend to be limited to one or a few O-antigen subunits while the group 4 capsules tend to form long chain O-antigen repeats.
Negative_regulation (limited) of capsule in capsules
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2897883 Disease Relevance 0 Pain Relevance 0
In addition, we examined the effect of protease inhibitors (PI) on apoptosis of NTrMCs/HTrMCs as well as morphine-induced superoxide dismutase (SOD) and nicotinamide adenine dinucleotide phosphate (reduced form) (NADPH) oxidase activation.
Negative_regulation (apoptosis) of NTrMCs
10) Confidence 0.01 Published 2004 Journal Kidney Int. Section Body Doc Link 14871405 Disease Relevance 0.25 Pain Relevance 0

General Comments

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