INT116431

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Context Info
Confidence 0.39
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 7.88
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYBB) oxidoreductase activity (CYBB) plasma membrane (CYBB)
cytoplasm (CYBB)
Anatomy Link Frequency
hippocampus 4
PLB-985 2
CYBB (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 5 100.00 Very High Very High Very High
ischemia 50 98.72 Very High Very High Very High
Tetrahydrobiopterin 8 94.00 High High
Inflammation 111 91.20 High High
cytokine 8 85.92 High High
antagonist 4 84.56 Quite High
cva 41 81.76 Quite High
rheumatoid arthritis 10 75.44 Quite High
Osteoarthritis 10 74.48 Quite High
cINOD 20 68.96 Quite High
Disease Link Frequency Relevance Heat
Stress 67 100.00 Very High Very High Very High
Injury 24 100.00 Very High Very High Very High
Cv General 4 Under Development 7 98.72 Very High Very High Very High
Disease 65 96.76 Very High Very High Very High
Death 21 95.76 Very High Very High Very High
Stroke 25 95.40 Very High Very High Very High
Cv Unclassified Under Development 45 95.20 Very High Very High Very High
Brain Injury 20 93.84 High High
Urological Neuroanatomy 47 92.72 High High
Apoptosis 14 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We suspected that this result might be explained by the large heterogeneity in the Nox2 expression level of PLB-985 clones (Fig. 6b).
Negative_regulation (level) of Gene_expression (expression) of Nox2 in PLB-985
1) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0.17 Pain Relevance 0
involved the inhibition of the NADPH-oxidase-dependent superoxide production,
Negative_regulation (inhibition) of Gene_expression (production) of NADPH-oxidase
2) Confidence 0.37 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.86 Pain Relevance 0.46
oxidative stress and injury in the gerbil hippocampus [36], and inhibiting superoxide production by NADPH-oxidase
Negative_regulation (stress) of Gene_expression (production) of NADPH-oxidase in hippocampus associated with stress, injury and hippocampus
3) Confidence 0.37 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 1.64 Pain Relevance 0.33
Nevertheless, Wilkins et al. [60] claim that NADPH-oxidase is
Negative_regulation (claim) of Gene_expression (is) of NADPH-oxidase
4) Confidence 0.37 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.71 Pain Relevance 0.03
oxidative stress and injury in the gerbil hippocampus [36], and inhibiting superoxide production by NADPH-oxidase
Negative_regulation (inhibiting) of Gene_expression (production) of NADPH-oxidase in hippocampus associated with stress, injury and hippocampus
5) Confidence 0.37 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 1.62 Pain Relevance 0.33
block NADPH-oxidase activation [10, 15].
Negative_regulation (block) of Gene_expression (activation) of NADPH-oxidase
6) Confidence 0.37 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.48 Pain Relevance 0.03
GLNVA also suppressed accumulation of iROS and up-regulated heme oxygenase-1 expression. 6-OHDA-induced overexpression of nNOS, iNOS, COX-2, and gp91(phox) was also reduced by GLNVA.
Negative_regulation (reduced) of Gene_expression (overexpression) of gp91
7) Confidence 0.25 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.64 Pain Relevance 0.16
Pretreatment of BV-2 cells with GLNVA diminished LPS-induced nitric oxide production, overexpression of inducible nitric-oxide synthase (iNOS), and gp91(phox) and intracellular reactive oxygen species (iROS).
Negative_regulation (diminished) of Gene_expression (production) of gp91
8) Confidence 0.25 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.99 Pain Relevance 0.20
Saquinavir also attenuated the morphine-induced expression of SOD and NADPH oxidase (Gp91phox) by HTrMCs.
Negative_regulation (attenuated) of Gene_expression (expression) of NADPH oxidase
9) Confidence 0.04 Published 2004 Journal Kidney Int. Section Body Doc Link 14871405 Disease Relevance 0 Pain Relevance 0
This intracellular ascorbate may protect microvascular function in two phases of action: initially by inhibiting NADPH oxidase activation and increasing eNOS activity, and subsequently by suppressing expression of NADPH oxidase, iNOS and tissue factor (Fig. 4).
Negative_regulation (inhibiting) of Gene_expression (activation) of NADPH oxidase
10) Confidence 0.04 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386519 Disease Relevance 0.44 Pain Relevance 0.09
This intracellular ascorbate may protect microvascular function in two phases of action: initially by inhibiting NADPH oxidase activation and increasing eNOS activity, and subsequently by suppressing expression of NADPH oxidase, iNOS and tissue factor (Fig. 4).
Negative_regulation (suppressing) of Gene_expression (expression) of NADPH oxidase
11) Confidence 0.04 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386519 Disease Relevance 0.33 Pain Relevance 0.09

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