INT116432

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Context Info
Confidence 0.40
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.88
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD1) peroxisome (SOD1) protein complex (SOD1)
cytoplasm (SOD1) cytosol (SOD1) extracellular space (SOD1)
Anatomy Link Frequency
skin 2
SOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 2 77.92 Quite High
Substantia nigra 1 67.96 Quite High
Calcium channel 1 67.60 Quite High
Thalamus 1 67.00 Quite High
Hippocampus 1 66.60 Quite High
Inflammation 31 59.84 Quite High
Spinal cord 10 47.84 Quite Low
imagery 19 5.00 Very Low Very Low Very Low
medulla 7 5.00 Very Low Very Low Very Low
Glutamate 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 190 99.96 Very High Very High Very High
Toxicity 7 97.16 Very High Very High Very High
Frontotemporal Lobar Degeneration 7 95.96 Very High Very High Very High
Stress 31 95.04 Very High Very High Very High
Dementia 12 94.68 High High
Skin Cancer 14 94.32 High High
Body Weight 6 94.24 High High
Syndrome 25 92.96 High High
Hypertension 32 90.40 High High
Cancer 76 86.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TDP-43 positive inclusions were also detected in one of two cases of PLS but appear to be negative in the inclusions seen in SOD1 positive familial ALS [183-185].


Positive_regulation (negative) of Positive_regulation (familial) of SOD1 associated with motor neuron diseases
1) Confidence 0.40 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2656493 Disease Relevance 2.20 Pain Relevance 0.10
However had we normalized the SOD values to serum proteins, it could have helped in better quantification of the increase, but we can definitely state that vitamin C in therapy augments the increase in SOD levels.
Positive_regulation (augments) of Positive_regulation (increase) of SOD
2) Confidence 0.20 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127225 Disease Relevance 0.49 Pain Relevance 0.07
In addition, we examined the effect of protease inhibitors (PI) on apoptosis of NTrMCs/HTrMCs as well as morphine-induced superoxide dismutase (SOD) and nicotinamide adenine dinucleotide phosphate (reduced form) (NADPH) oxidase activation.
Spec (examined) Positive_regulation (morphine-induced) of Positive_regulation (induced) of SOD
3) Confidence 0.12 Published 2004 Journal Kidney Int. Section Body Doc Link 14871405 Disease Relevance 0.24 Pain Relevance 0
In order to determine whether the Protandim diet could induce SOD expression/activity and catalase expression in skin epidermal tissues within a short period of time, animals were fed with either of the two diets for three weeks.
Positive_regulation (induce) of Positive_regulation (activity) of SOD in skin
4) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.09 Pain Relevance 0
After three weeks on the diets, there was a significant increase in the expression levels of SOD and catalase, in addition to the increases in SOD activities.
Positive_regulation (increase) of Positive_regulation (increases) of SOD
5) Confidence 0.06 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2668769 Disease Relevance 0.85 Pain Relevance 0.03

General Comments

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