INT116433

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Context Info
Confidence 0.70
First Reported 2004
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 93
Total Number 93
Disease Relevance 50.44
Pain Relevance 11.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYBB) oxidoreductase activity (CYBB) plasma membrane (CYBB)
cytoplasm (CYBB)
Anatomy Link Frequency
PLB-985 8
endothelial cells 4
PSCs 3
phagocyte 2
cardiomyocyte 2
CYBB (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 161 100.00 Very High Very High Very High
cINOD 174 99.78 Very High Very High Very High
midbrain 38 99.76 Very High Very High Very High
Hippocampus 27 99.34 Very High Very High Very High
Adalimumab 73 99.20 Very High Very High Very High
Chronic pancreatitis 10 99.12 Very High Very High Very High
cva 178 98.80 Very High Very High Very High
qutenza 38 98.12 Very High Very High Very High
Inflammatory response 117 97.80 Very High Very High Very High
Inflammation 973 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 691 100.00 Very High Very High Very High
Brain Injury 90 100.00 Very High Very High Very High
Atherosclerosis 257 99.48 Very High Very High Very High
Aging 1557 99.28 Very High Very High Very High
Pancreatitis 10 99.12 Very High Very High Very High
Stress 647 99.06 Very High Very High Very High
Adhesions 109 98.96 Very High Very High Very High
Obesity 2074 98.92 Very High Very High Very High
Injury 233 98.82 Very High Very High Very High
Hemorrhage 161 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We suspected that this result might be explained by the large heterogeneity in the Nox2 expression level of PLB-985 clones (Fig. 6b).
Gene_expression (expression) of Nox2 in PLB-985
1) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0.17 Pain Relevance 0
To test whether this parallel change in protein level reflects an interdependence of Hv1 and Nox2 expression, the experiment was repeated in Nox2 deficient (X CGD) PLB-985 cells.
Gene_expression (expression) of Nox2 in PLB-985
2) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0.12 Pain Relevance 0
We decided to use PLB-985 cells to study the relationship between Hv1 and Nox2 expression, since a Nox2 gene-disrupted clone is also available (PLB-985 X CGD [28]).
Gene_expression (expression) of Nox2 in PLB-985
3) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0.20 Pain Relevance 0
The phagosomal accumulation of Hv1 does not appear to require a functional oxidase, because strong clustering of the aHv1-N signal could also be detected in differentiated PLB-985 X CGD cells, a PLB-985 clone in which Nox2 is absent (i.e. the mutant, ?
Neg (absent) Gene_expression (absent) of Nox2 in PLB-985
4) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0.08 Pain Relevance 0
Hv1 expression might be impaired in PLB-985 X CGD cells for the following reasons: a) PLB-985 X CGD clone has a general differentiation problem, b) PLB-985 X CGD is a clone in which Hv1 expression is diminished in a Nox2 independent manner or c) normal Nox2 expression is required for normal Hv1 expression.
Gene_expression (expression) of Nox2 in PLB-985
5) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0 Pain Relevance 0
The expression level of both Hv1 and Nox2 gradually increased after inducing differentiation with DMFA (Fig. 6a).
Gene_expression (expression) of Nox2
6) Confidence 0.70 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0.19 Pain Relevance 0
Nox2 (formerly known as gp91phox) expression is upregulated and is associated
Gene_expression (expression) of gp91phox
7) Confidence 0.67 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.56 Pain Relevance 0.04
In line with this assumption, the density of voltage-gated proton current correlates well with Hv1 (see above), but not with Nox2 [1] expression among different human leukocyte types and among PLB-985 clones (Fig. 5).
Gene_expression (expression) of Nox2 in PLB-985
8) Confidence 0.61 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0.08 Pain Relevance 0
We decided to use PLB-985 cells to study the relationship between Hv1 and Nox2 expression, since a Nox2 gene-disrupted clone is also available (PLB-985 X CGD [28]).
Gene_expression (expression) of Nox2 in PLB-985
9) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0.20 Pain Relevance 0
this study, apocynin, upon peroxidase-catalyzed metabolic activation, interferes with NADPH-oxidase
Gene_expression (interferes) of NADPH-oxidase
10) Confidence 0.58 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.56 Pain Relevance 0.03
However, HMDM from patients with CGD that were shown to lack active NADPH-oxidase, but
Neg (lack) Gene_expression (lack) of NADPH-oxidase associated with disease
11) Confidence 0.58 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.67 Pain Relevance 0
Local administration of an NADPH-oxidase
Gene_expression (administration) of NADPH-oxidase
12) Confidence 0.58 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.50 Pain Relevance 0.04
is reported that apocynin had no effects not only on enhanced NADPH-oxidase
Neg (no) Gene_expression (had) of NADPH-oxidase
13) Confidence 0.58 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 1.57 Pain Relevance 0.45
oxidative stress and injury in the gerbil hippocampus [36], and inhibiting superoxide production by NADPH-oxidase
Gene_expression (production) of NADPH-oxidase in hippocampus associated with stress, injury and hippocampus
14) Confidence 0.58 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 1.61 Pain Relevance 0.33
M) and stimulated with the phospholipase A2 activator thrombin, showed NADPH-oxidase
Gene_expression (showed) of NADPH-oxidase
15) Confidence 0.58 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.87 Pain Relevance 0.07
of NADPH-oxidase activity and concomitant ROS production (IC50 value: 10 ?
Gene_expression (activity) of NADPH-oxidase
16) Confidence 0.58 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.12 Pain Relevance 0
Reactive oxygen species generated by NADPH-oxidase also
Gene_expression (generated) of NADPH-oxidase
17) Confidence 0.58 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.52 Pain Relevance 0.03
that the Nox2 catalytic component of NADPH-oxidase is upregulated in a
Gene_expression (component) of Nox2
18) Confidence 0.58 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.77 Pain Relevance 0.04
Nevertheless, Wilkins et al. [60] claim that NADPH-oxidase is
Gene_expression (is) of NADPH-oxidase
19) Confidence 0.58 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.71 Pain Relevance 0.03
that the Nox2 catalytic component of NADPH-oxidase is upregulated in a
Gene_expression (component) of NADPH-oxidase
20) Confidence 0.58 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.78 Pain Relevance 0.04

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