INT116434

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Context Info
Confidence 0.62
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 27
Total Number 30
Disease Relevance 16.24
Pain Relevance 5.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYBB) oxidoreductase activity (CYBB) plasma membrane (CYBB)
cytoplasm (CYBB)
Anatomy Link Frequency
phagocyte 8
endothelial cells 4
PLB-985 4
heart 3
brain 2
CYBB (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 68 99.98 Very High Very High Very High
cva 73 99.36 Very High Very High Very High
diclofenac 6 98.52 Very High Very High Very High
rheumatoid arthritis 16 97.48 Very High Very High Very High
Osteoarthritis 16 96.52 Very High Very High Very High
Inflammation 260 95.12 Very High Very High Very High
Bioavailability 19 94.92 High High
antagonist 15 91.40 High High
cytokine 31 86.52 High High
imagery 9 84.60 Quite High
Disease Link Frequency Relevance Heat
Brain Injury 32 100.00 Very High Very High Very High
Hemorrhage 64 99.36 Very High Very High Very High
Adhesions 50 98.96 Very High Very High Very High
Diabetes Mellitus 207 98.76 Very High Very High Very High
Atherosclerosis 97 98.56 Very High Very High Very High
Aging 125 98.44 Very High Very High Very High
Hypertension 124 98.40 Very High Very High Very High
Obesity 184 97.80 Very High Very High Very High
Rheumatoid Arthritis 16 97.48 Very High Very High Very High
Hemorrhagic Shock 64 97.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hv1 expression might be impaired in PLB-985 X CGD cells for the following reasons: a) PLB-985 X CGD clone has a general differentiation problem, b) PLB-985 X CGD is a clone in which Hv1 expression is diminished in a Nox2 independent manner or c) normal Nox2 expression is required for normal Hv1 expression.
Positive_regulation (required) of Gene_expression (expression) of Nox2 in PLB-985
1) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0 Pain Relevance 0
The expression of Nox1, Nox2, Nox4, and p22phox was increased markedly by the nonselective NSAIDs diclofenac or naproxen and moderately by rofecoxib or celecoxib in the aorta and heart of SHR.
Positive_regulation (increased) of Gene_expression (expression) of Nox2 in heart associated with cinod and diclofenac
2) Confidence 0.48 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18550689 Disease Relevance 0.33 Pain Relevance 0.75
The expression level of both Hv1 and Nox2 gradually increased after inducing differentiation with DMFA (Fig. 6a).
Positive_regulation (increased) of Gene_expression (expression) of Nox2
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0.19 Pain Relevance 0
To test whether this parallel change in protein level reflects an interdependence of Hv1 and Nox2 expression, the experiment was repeated in Nox2 deficient (X CGD) PLB-985 cells.
Spec (whether) Positive_regulation (interdependence) of Gene_expression (expression) of Nox2 in PLB-985
4) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2990768 Disease Relevance 0.12 Pain Relevance 0
that the Nox2 catalytic component of NADPH-oxidase is upregulated in a
Positive_regulation (upregulated) of Gene_expression (component) of NADPH-oxidase
5) Confidence 0.44 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.78 Pain Relevance 0.04
that the Nox2 catalytic component of NADPH-oxidase is upregulated in a
Positive_regulation (upregulated) of Gene_expression (component) of Nox2
6) Confidence 0.44 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.78 Pain Relevance 0.04
Nox2 (formerly known as gp91phox) expression is upregulated and is associated
Positive_regulation (upregulated) of Gene_expression (expression) of gp91phox
7) Confidence 0.44 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.57 Pain Relevance 0.04
results in the activation of NADPH-oxidase and brain injury that cannot be
Positive_regulation (activation) of Gene_expression (injury) of NADPH-oxidase in brain associated with brain injury
8) Confidence 0.44 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 1.59 Pain Relevance 0.45
Reactive oxygen species generated by NADPH-oxidase also
Positive_regulation (generated) of Gene_expression (generated) of NADPH-oxidase
9) Confidence 0.44 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.52 Pain Relevance 0.03
The upregulation of Hv1 or Nox2 expression did not require the normal expression of the other molecule.
Positive_regulation (upregulation) of Gene_expression (expression) of Nox2
10) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2990768 Disease Relevance 0.14 Pain Relevance 0.04
Nox2 (formerly known as gp91phox) expression is upregulated and is associated
Positive_regulation (upregulated) of Gene_expression (expression) of Nox2
11) Confidence 0.40 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.57 Pain Relevance 0.05
of Nox1, Nox2, or Nox4 when overexpressed in endothelial cells.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Nox2 in endothelial cells
12) Confidence 0.40 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.06 Pain Relevance 0
generating enzyme NADPH-oxidase [12, 13] present in
Positive_regulation (generating) of Gene_expression (generating) of enzyme NADPH-oxidase
13) Confidence 0.38 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.78 Pain Relevance 0.41
Also in human endothelial cells, NSAIDs increased Nox2 expression and diminished production of bioactive NO.
Positive_regulation (increased) of Gene_expression (expression) of Nox2 in endothelial cells associated with cinod
14) Confidence 0.34 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18550689 Disease Relevance 0.30 Pain Relevance 0.90
GLNVA also decreased LPS activated microglia induced overexpression of neuronal nitric-oxide synthase (nNOS) and glycoprotein 91 phagocyte oxidase (gp91(phox)) on SH-SY5Y cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of gp91 in phagocyte
15) Confidence 0.30 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.88 Pain Relevance 0.20
GLNVA also suppressed accumulation of iROS and up-regulated heme oxygenase-1 expression. 6-OHDA-induced overexpression of nNOS, iNOS, COX-2, and gp91(phox) was also reduced by GLNVA.
Positive_regulation (overexpression) of Gene_expression (overexpression) of gp91
16) Confidence 0.30 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.64 Pain Relevance 0.16
GLNVA also decreased LPS activated microglia induced overexpression of neuronal nitric-oxide synthase (nNOS) and glycoprotein 91 phagocyte oxidase (gp91(phox)) on SH-SY5Y cells.
Positive_regulation (induced) of Gene_expression (overexpression) of gp91 in phagocyte
17) Confidence 0.30 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.89 Pain Relevance 0.20
GLNVA also suppressed accumulation of iROS and up-regulated heme oxygenase-1 expression. 6-OHDA-induced overexpression of nNOS, iNOS, COX-2, and gp91(phox) was also reduced by GLNVA.
Positive_regulation (6-OHDA-induced) of Gene_expression (overexpression) of gp91
18) Confidence 0.30 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.64 Pain Relevance 0.16
GLNVA also decreased LPS activated microglia induced overexpression of neuronal nitric-oxide synthase (nNOS) and glycoprotein 91 phagocyte oxidase (gp91(phox)) on SH-SY5Y cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of glycoprotein 91 phagocyte oxidase in phagocyte
19) Confidence 0.30 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.88 Pain Relevance 0.20
GLNVA also decreased LPS activated microglia induced overexpression of neuronal nitric-oxide synthase (nNOS) and glycoprotein 91 phagocyte oxidase (gp91(phox)) on SH-SY5Y cells.
Positive_regulation (induced) of Gene_expression (overexpression) of glycoprotein 91 phagocyte oxidase in phagocyte
20) Confidence 0.30 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.89 Pain Relevance 0.20

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