INT116436

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Context Info
Confidence 0.40
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.94
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
endoplasmic reticulum (TP53) enzyme binding (TP53) protein complex assembly (TP53)
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 15 99.56 Very High Very High Very High
Somatostatin 4 86.00 High High
withdrawal 1 43.68 Quite Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 15 99.92 Very High Very High Very High
Stress 9 75.00 Quite High
Cancer 4 73.60 Quite High
Aging 57 62.64 Quite High
Retinoblastoma 6 52.72 Quite High
Intervertebral Disk Degeneration 8 5.00 Very Low Very Low Very Low
Necrosis 4 5.00 Very Low Very Low Very Low
Shock 4 5.00 Very Low Very Low Very Low
Intervertebral Disk Displacement 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with the antioxidant N-acetyl-L-cystein and catalase, but not superoxide dismutase, completely inhibited capsaicin-induced apoptosis by inhibiting phosphorylation of Ser-15 residue of p53.
Negative_regulation (inhibiting) of Phosphorylation (phosphorylation) of p53 associated with qutenza and apoptosis
1) Confidence 0.40 Published 2004 Journal Cancer Res. Section Abstract Doc Link 14871840 Disease Relevance 0.63 Pain Relevance 1.07
Yang et al. have proposed that it has its action by inhibiting extracellular signal-regulated kinase, enhancing the transcriptional activity of p53, and inhibiting p53 phosphorylation.
Negative_regulation (inhibiting) of Phosphorylation (phosphorylation) of p53
2) Confidence 0.23 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2828399 Disease Relevance 0.32 Pain Relevance 0.08

General Comments

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