INT116440

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Context Info
Confidence 0.14
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.09
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (LY9, CCL2) aging (CCL2) cytoplasm (CCL2)
extracellular space (CCL2) signal transduction (CCL2) extracellular region (CCL2)
LY9 (Homo sapiens)
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 93.96 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 2 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that LY29 inhibits MCP-1 expression at least in part via suppression of NF-kappaB, independent of PI3K, and the structure of LY29 and LY30 may be a novel template for development of new anti-inflammatory drugs.
LY29 Negative_regulation (inhibits) of Gene_expression (expression) of MCP-1 associated with inflammation and cinod
1) Confidence 0.14 Published 2004 Journal FEBS Lett. Section Abstract Doc Link 14960322 Disease Relevance 0.09 Pain Relevance 0.09
At these concentrations, LY29, but not WM, significantly inhibited constitutive and IL-1beta-induced MCP-1 expression at both protein and mRNA levels.
LY29 Negative_regulation (inhibited) of Gene_expression (expression) of MCP-1
2) Confidence 0.09 Published 2004 Journal FEBS Lett. Section Abstract Doc Link 14960322 Disease Relevance 0 Pain Relevance 0.07

General Comments

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