INT116441

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Context Info
Confidence 0.04
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.62
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL1B, CCL2) extracellular space (IL1B, CCL2) aging (IL1B, CCL2)
extracellular region (IL1B, CCL2) cytosol (IL1B) cell adhesion (CCL2)
Anatomy Link Frequency
joint 2
IL1B (Homo sapiens)
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 17 100.00 Very High Very High Very High
rheumatoid arthritis 121 90.40 High High
antagonist 1 85.96 High High
Inflammation 30 70.32 Quite High
cINOD 1 68.40 Quite High
Infliximab 5 58.60 Quite High
Arthritis 10 56.52 Quite High
Etanercept 1 54.32 Quite High
Pain 2 45.04 Quite Low
methotrexate 1 31.12 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 121 90.40 High High
INFLAMMATION 28 70.32 Quite High
Arthritis 10 56.52 Quite High
Disease 13 53.80 Quite High
Apoptosis 5 50.00 Quite Low
Pain 2 45.04 Quite Low
Adhesions 28 15.92 Low Low
Osteoarthritis 18 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 9 5.00 Very Low Very Low Very Low
Hypoxia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-1 and TNF stimulate the production of degradative proteases and cytokines such as IL-1, IL-6, IL-8 and MCP-1 by joint tissue cells, contributing to joint destruction.
IL-1 Positive_regulation (stimulate) of Gene_expression (production) of MCP-1 in joint associated with cytokine
1) Confidence 0.04 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.62 Pain Relevance 0.58
At these concentrations, LY29, but not WM, significantly inhibited constitutive and IL-1beta-induced MCP-1 expression at both protein and mRNA levels.
IL-1beta-induced Positive_regulation (induced) of Gene_expression (expression) of MCP-1
2) Confidence 0.03 Published 2004 Journal FEBS Lett. Section Abstract Doc Link 14960322 Disease Relevance 0 Pain Relevance 0.07

General Comments

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