INT116450

Context Info Confidence 0.08 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.10

small molecule metabolic process (POMC, LHB) cell-cell signaling (POMC, LHB) signal transduction (POMC, LHB) extracellular region (POMC, LHB) cellular nitrogen compound metabolic process (POMC, LHB) cytoplasm (POMC)

Anatomy Link Frequency pituitary gland 2 POMC (Homo sapiens) LHB (Homo sapiens)

Pain Link Frequency Relevance Heat opiate 1 99.80

Disease Link Frequency Relevance Heat Urological Neuroanatomy 2 37.20 Increased Venous Pressure Under Development 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Endogenous opiates, such as beta-endorphin, inhibit the release of luteinizing hormone (LH) release in the pituitary gland of several species including rat, pig, sheep, and human.

beta-endorphin Negative_regulation (inhibit) of Localization (release) of luteinizing hormone in pituitary gland associated with opiate

1) Confidence 0.08 Published 2004 Journal Neuroscience Section Abstract Doc Link 14960353 Disease Relevance 0 Pain Relevance 0.10

General Comments

This test has worked.