INT116463

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2010
Negated 4
Speculated 0
Reported most in Body
Documents 40
Total Number 50
Disease Relevance 33.99
Pain Relevance 2.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Birc5) chromosome segregation (Birc5) intracellular (Birc5)
enzyme binding (Birc5) embryo development (Birc5) cytoplasm (Birc5)
Anatomy Link Frequency
colon 6
THP-1 6
lateral ventricles 4
embryos 2
myocardium 2
Birc5 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 230 99.56 Very High Very High Very High
Hippocampus 150 99.52 Very High Very High Very High
chemokine 21 97.56 Very High Very High Very High
fibrosis 15 97.04 Very High Very High Very High
cytokine 35 96.96 Very High Very High Very High
Inflammation 60 96.56 Very High Very High Very High
Taxol 4 94.32 High High
COX-2 inhibitor 61 93.60 High High
Inflammatory stimuli 4 92.04 High High
headache 6 88.88 High High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 335 99.98 Very High Very High Very High
Cancer 2172 99.84 Very High Very High Very High
Lung Cancer 315 99.70 Very High Very High Very High
Diabetes Mellitus 96 99.68 Very High Very High Very High
Carcinoma In Situ 2 99.62 Very High Very High Very High
Pancreatic Cancer 184 99.32 Very High Very High Very High
Adenoma 2 99.20 Very High Very High Very High
Apoptosis 1499 99.04 Very High Very High Very High
Death 341 97.64 Very High Very High Very High
Solid Tumor 29 97.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As noted above, survivin expression in the SGZ of the DG was not appreciably diminished after cre excision.
Neg (not) Negative_regulation (diminished) of Gene_expression (expression) of survivin
1) Confidence 0.59 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.19 Pain Relevance 0
Surprisingly, expression of survivin in the SGZ was not decreased postnatally in SurvivinCamcre mice (Figure 2I).
Neg (not) Negative_regulation (decreased) of Gene_expression (expression) of survivin
2) Confidence 0.59 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.21 Pain Relevance 0.04
In situ hybridization confirmed loss of survivin expression in the SVZ and RMS (Figure 2A, B, F, G).
Negative_regulation (loss) of Gene_expression (expression) of survivin
3) Confidence 0.59 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.22 Pain Relevance 0.03
At E14.5 and E17.5, survivin expression in the SurvivinCamcre embyros was markedly reduced in the ganglionic eminences surrounding the lateral ventricles where mitotically active NPCs normally reside, in the RMS and in the OB (Figure 1F, H, J, L).
Negative_regulation (reduced) of Gene_expression (expression) of survivin in lateral ventricles
4) Confidence 0.59 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.26 Pain Relevance 0.12
Within these neurogenic regions, a subpopulation of NPCs continues to express survivin, which is downregulated once the cells differentiate into neurons.
Negative_regulation (downregulated) of Gene_expression (express) of survivin in neurons
5) Confidence 0.59 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0 Pain Relevance 0.04
The hypoplastic OB and absent RMS, in concert with reduced expression of NPC survivin in the SurvivinCamcre mice might be caused by decreased NPC proliferation, increased cell death, and/or deficits in migration.
Negative_regulation (reduced) of Gene_expression (expression) of survivin associated with death
6) Confidence 0.59 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.10 Pain Relevance 0.04
This latter observation is of particular relevance, as it has been demonstrated that suppression of survivin expression by RNA interference causes loss of mitochondrial membrane potential and spontaneous apoptosis [63].
Negative_regulation (suppression) of Gene_expression (expression) of survivin associated with apoptosis
7) Confidence 0.57 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.80 Pain Relevance 0.06
Compared to our results presented here, these reports further emphasize our observation that celecoxib and DMC are unique in that these two drugs are able to suppress survivin expression at significantly lower concentrations than other NSAIDs.
Negative_regulation (suppress) of Gene_expression (expression) of survivin associated with cinod
8) Confidence 0.57 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.36 Pain Relevance 0.18
Our efforts to understand the mechanisms by which DMC accomplishes the down-regulation of survivin revealed that at least part of this regulation occurs at the level of transcription, i.e., our results clearly indicate that DMC is able to potently inhibit survivin expression at the gene level via the inhibition of promoter activity (Figure 4).
Negative_regulation (inhibit) of Gene_expression (expression) of survivin
9) Confidence 0.57 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.44 Pain Relevance 0
As convincingly demonstrated by our results, both celecoxib and DMC were able to potently inhibit survivin expression in tumors of a xenograft mouse tumor model (Figure 8).
Negative_regulation (inhibit) of Gene_expression (expression) of survivin associated with cancer
10) Confidence 0.57 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.45 Pain Relevance 0
M celecoxib completely suppressed survivin expression, which was accompanied by severe cytotoxicity (not shown).


Negative_regulation (suppressed) of Gene_expression (expression) of survivin
11) Confidence 0.57 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.91 Pain Relevance 0
The reduced expression of survivin in the diabetic myocardium can be correlated to the increased myocardial fibrosis as evidenced by trichrome staining.
Negative_regulation (reduced) of Gene_expression (expression) of survivin in myocardium associated with fibrosis and diabetes mellitus
12) Confidence 0.57 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.72 Pain Relevance 0.08
However, further increased concentrations of these two drugs invariably led to complete downregulation of survivin expression in all cell lines examined, i.e., 60–70 ?
Negative_regulation (downregulation) of Gene_expression (expression) of survivin
13) Confidence 0.57 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.95 Pain Relevance 0
There are a few reports from other groups [55-58] indicating that, in addition to celecoxib, some other NSAIDs appear to be able to reduce survivin expression, and these findings could be viewed as being discrepant to ours.
Negative_regulation (reduce) of Gene_expression (expression) of survivin associated with cinod
14) Confidence 0.57 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.54 Pain Relevance 0.16
The blockage of EGFR and STAT3-signaling cascades seemingly increased the levels of p53, Bax and decreased levels of Bcl-xL, survivin, and cyclin D1 proteins.
Negative_regulation (decreased) of Gene_expression (levels) of survivin
15) Confidence 0.57 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 1.06 Pain Relevance 0
Despite the fetal abnormalities, and in striking contrast to the RMS-OB, there were no obvious structural defects or alterations in hippocampal neurogenesis in the SurvivinCamcre mice that had no appreciable reduction in survivin expression within the hippocampus.


Neg (no) Negative_regulation (reduction) of Gene_expression (expression) of survivin in hippocampus associated with congenital anomalies, hippocampus and neurodegenerative disease
16) Confidence 0.51 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.64 Pain Relevance 0.09
Somewhat surprisingly, in spite of profound disturbances in neurogenesis in the SVZ, we did not detect baseline changes in neurogenesis in the SGZ of the DG in the SurvivinCamcre mice, or significant loss of survivin expressing DG NPCs.
Negative_regulation (loss) of Gene_expression (expressing) of survivin associated with neurodegenerative disease
17) Confidence 0.43 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.98 Pain Relevance 0.03
Mature neuronal marker NeuN [29] immunoreactivity did not overlap with survivin, consistent with the lack of survivin expression by mature neurons (Figure 2C-E).
Negative_regulation (lack) of Gene_expression (expression) of survivin in neuronal
18) Confidence 0.43 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0 Pain Relevance 0.03
It has been shown in several other experimental systems that the down-regulation of survivin expression, for example by antisense or siRNA approaches [65], results in elevated "basal level" apoptosis and, perhaps more importantly, causes substantially increased sensitivity of such tumor cells to killing by chemotherapeutic drugs or ionizing radiation (for examples, see [66-71]).
Negative_regulation (down) of Gene_expression (expression) of survivin associated with cancer and apoptosis
19) Confidence 0.42 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.81 Pain Relevance 0
As shown in Figure 1, both drugs were able to down-regulate survivin expression in all cell lines investigated, which included cells derived from glioblastoma, lymphoma, multiple myeloma, and carcinoma of the breast, colon, and prostate.
Negative_regulation (-) of Gene_expression (expression) of survivin in colon associated with lymphatic system cancer, glioblastoma, multiple myeloma and reprotox - general 1
20) Confidence 0.42 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 1.28 Pain Relevance 0

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