INT116464

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 53
Total Number 53
Disease Relevance 45.40
Pain Relevance 4.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Birc5) chromosome segregation (Birc5) intracellular (Birc5)
enzyme binding (Birc5) embryo development (Birc5) cytoplasm (Birc5)
Anatomy Link Frequency
neurogenic regions 2
joint 2
embryos 1
T98G 1
MIA PaCa-2 1
Birc5 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 424 99.92 Very High Very High Very High
Inflammatory response 19 99.84 Very High Very High Very High
antagonist 43 98.52 Very High Very High Very High
cINOD 283 96.48 Very High Very High Very High
Central nervous system 26 96.16 Very High Very High Very High
Arthritis 24 96.08 Very High Very High Very High
GABAergic 63 96.00 Very High Very High Very High
Hippocampus 118 95.16 Very High Very High Very High
COX-2 inhibitor 170 89.44 High High
amygdala 9 87.48 High High
Disease Link Frequency Relevance Heat
Cancer 2513 100.00 Very High Very High Very High
Apoptosis 1795 100.00 Very High Very High Very High
Neurodegenerative Disease 244 100.00 Very High Very High Very High
Disease 189 100.00 Very High Very High Very High
Rheumatoid Arthritis 427 99.92 Very High Very High Very High
Immunotherapy Of Cancer 24 99.92 Very High Very High Very High
INFLAMMATION 185 99.84 Very High Very High Very High
Death 394 99.68 Very High Very High Very High
Convulsion 351 99.46 Very High Very High Very High
Osteogenic Sarcomas 4 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, lack of NPC survivin results in increased embryonic NPC death and decreased NPC proliferation in specific embryonic neurogenic regions.


Negative_regulation (lack) of survivin in neurogenic regions associated with death
1) Confidence 0.59 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.35 Pain Relevance 0.09
Somewhat surprisingly, in spite of profound disturbances in neurogenesis in the SVZ, we did not detect baseline changes in neurogenesis in the SGZ of the DG in the SurvivinCamcre mice, or significant loss of survivin expressing DG NPCs.
Negative_regulation (loss) of survivin associated with neurodegenerative disease
2) Confidence 0.59 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.97 Pain Relevance 0
downregulating antiapoptotic proteins such as survivin and Bcl-2 [148].
Negative_regulation (downregulating) of survivin
3) Confidence 0.57 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 0.89 Pain Relevance 0.03
With regard to apoptosis, the activation of caspase-3 and caspase-9 and the downregulation of bcl-2 and survivin were observed with the apoptotic activity induced by VPA in the present study.
Negative_regulation (downregulation) of survivin associated with apoptosis
4) Confidence 0.57 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.76 Pain Relevance 0.04
To study the in vivo role of NPC survivin, we generated mice in which the survivin gene is inactivated in the neurogenic regions of the brain prenatally.
Negative_regulation (inactivated) of survivin gene in neurogenic regions
5) Confidence 0.43 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.07 Pain Relevance 0.05
Impaired neurogenesis, learning and memory and low seizure threshold associated with loss of neural precursor cell survivin

Background

Negative_regulation (loss) of survivin in precursor cell associated with convulsion and neurodegenerative disease
6) Confidence 0.43 Published 2010 Journal BMC Neurosci Section Title Doc Link PMC2817683 Disease Relevance 0.35 Pain Relevance 0.03
Within these neurogenic regions, a subpopulation of NPCs continues to express survivin, which is downregulated once the cells differentiate into neurons.
Negative_regulation (downregulated) of survivin in neurons
7) Confidence 0.43 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0 Pain Relevance 0.04
In contrast, and consistent with prominent apoptosis and diminished BrdU labeling in the ganglionic eminences, prenatal depletion of survivin in the NPCs of SurvivinCamcre mice resulted in a significant reduction in the density of GAD65/67+ GABAergic interneurons in the postnatal adult cortex (493 + 12 cells/mm2 versus 417 + 6 cells/mm2 in controls and SurvivinCamcre mice, respectively, n = 5-6 mice per group, p < 0.001) (Figure 5D-F).
Negative_regulation (depletion) of survivin in interneurons associated with gabaergic and apoptosis
8) Confidence 0.43 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.23 Pain Relevance 0.12
On the other hand, at these same concentrations of DMC, LN229 and MIA PaCa-2 cells exhibited only a minor down-regulation of survivin, which correlated with marginally increased apoptosis and a much weaker effect on overall cell survival (Figure 5).
Negative_regulation (down-regulation) of survivin in MIA PaCa-2 associated with apoptosis
9) Confidence 0.42 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.82 Pain Relevance 0
When combined with irinotecan, a widely used anticancer drug, celecoxib and DMC greatly enhance the cytotoxic effects of this drug, in keeping with a model that suppression of survivin may be beneficial to sensitize cancer cells to chemotherapy.
Negative_regulation (suppression) of survivin associated with cancer
10) Confidence 0.42 Published 2006 Journal Mol Cancer Section Abstract Doc Link PMC1479836 Disease Relevance 1.15 Pain Relevance 0.08
Down-regulation of survivin is independent of p53
Negative_regulation (Down-regulation) of survivin
11) Confidence 0.42 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.83 Pain Relevance 0
The extent of survivin down-regulation by celecoxib and DMC in different tumor cell lines is somewhat variable, but closely correlates with the degree of drug-induced growth inhibition and apoptosis.
Negative_regulation (down) of survivin associated with cancer and apoptosis
12) Confidence 0.42 Published 2006 Journal Mol Cancer Section Abstract Doc Link PMC1479836 Disease Relevance 0.98 Pain Relevance 0.10
As shown in Figure 5, U251, T98G, and BxPc-3 cells responded quite sensitively; these cells displayed a potent down-regulation of survivin, and at the same time strongly increased apoptosis in combination with greatly reduced survival.
Negative_regulation (down-regulation) of survivin in T98G associated with apoptosis
13) Confidence 0.42 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.73 Pain Relevance 0
Down-regulation of survivin is independent of cyclooxygenase-2
Negative_regulation (regulation) of survivin
14) Confidence 0.42 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.47 Pain Relevance 0
Considering the well-known function of survivin as an inhibitor of caspases and, consequently, as an anti-apoptotic protein [35,64], it is not surprising that down-regulation of this protein by celecoxib and DMC is associated with increased cell death.
Negative_regulation (regulation) of survivin associated with apoptosis and death
15) Confidence 0.42 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.94 Pain Relevance 0
The blockage of EGFR and STAT3-signaling cascades seemingly increased the levels of p53, Bax and decreased levels of Bcl-xL, survivin, and cyclin D1 proteins.
Negative_regulation (decreased) of survivin
16) Confidence 0.42 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 1.06 Pain Relevance 0
Down-regulation of survivin involves transcriptional repression
Negative_regulation (regulation) of survivin associated with repression
17) Confidence 0.42 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1479836 Disease Relevance 0.35 Pain Relevance 0.24
activation, whereas inhibitors of apoptosis protein (IAPs) such as survivin
Negative_regulation (inhibitors) of survivin associated with apoptosis
18) Confidence 0.42 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.71 Pain Relevance 0.03
Exposure to reg4 antibody resulted in a significant decrease in intra-tumor levels of pAkt, Bcl-xL, Bcl-2, survivin and cyclin D1.


Negative_regulation (decrease) of survivin associated with cancer
19) Confidence 0.42 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2760775 Disease Relevance 1.01 Pain Relevance 0
This effect was due to a down-regulation of MnSOD (superoxide dismutase containing manganese (Mn) and localized in mitochondria), a primary antioxidant protein and survivin, an anti-apoptotic protein (IAPS family member).
Negative_regulation (regulation) of survivin associated with apoptosis
20) Confidence 0.42 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.21 Pain Relevance 0.07

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox