INT116465

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 7
Speculated 10
Reported most in Body
Documents 241
Total Number 257
Disease Relevance 192.31
Pain Relevance 15.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear chromosome (Birc5) chromosome segregation (Birc5) intracellular (Birc5)
enzyme binding (Birc5) embryo development (Birc5) cytoplasm (Birc5)
Anatomy Link Frequency
AsPC-1 4
synovial fluid 4
A24 4
THP-1 4
thymus 4
Birc5 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 106 99.84 Very High Very High Very High
chemokine 164 99.62 Very High Very High Very High
cINOD 431 99.58 Very High Very High Very High
Hippocampus 644 99.52 Very High Very High Very High
Chronic pancreatitis 58 99.50 Very High Very High Very High
cytokine 266 99.32 Very High Very High Very High
rheumatoid arthritis 2412 99.28 Very High Very High Very High
GABAergic 343 99.24 Very High Very High Very High
Inflammation 449 99.12 Very High Very High Very High
Taxol 11 98.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 7266 100.00 Very High Very High Very High
Apoptosis 4949 100.00 Very High Very High Very High
Carcinoma 66 99.92 Very High Very High Very High
Pancreatic Cancer 2406 99.84 Very High Very High Very High
Lung Cancer 1275 99.84 Very High Very High Very High
INFLAMMATION 634 99.84 Very High Very High Very High
Malignant Neoplastic Disease 299 99.84 Very High Very High Very High
Neuroblastoma 113 99.84 Very High Very High Very High
Stomach Cancer 33 99.84 Very High Very High Very High
Nasopharynx Cancer 435 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, survivin expression is restricted during fetal development to NPCs in neurogenic regions of the telencephalon, of which a fraction populates the major neurogenic regions of the postnatal brain, i.e. the SVZ and the SGZ.
Gene_expression (expression) of survivin in neurogenic regions
1) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0 Pain Relevance 0.03
Survivin mRNA was detected in the neurogenic areas of the dorsal and ventral telencephalon surrounding the ventricles (neocortex, medial and lateral ganglionic eminences (MGE and LGE, respectively)) (Figure 1A).
Gene_expression (detected) of Survivin mRNA in neocortex
2) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.29 Pain Relevance 0.03
Postnatally, survivin expression was restricted largely to rapidly proliferating cells [21] and migrating NPCs [27].
Gene_expression (expression) of survivin
3) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0 Pain Relevance 0
As noted above, survivin expression in the SGZ of the DG was not appreciably diminished after cre excision.
Gene_expression (expression) of survivin
4) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.18 Pain Relevance 0
Surprisingly, expression of survivin in the SGZ was not decreased postnatally in SurvivinCamcre mice (Figure 2I).
Gene_expression (expression) of survivin
5) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.21 Pain Relevance 0.03
At E14.5 and E17.5, survivin expression in the SurvivinCamcre embyros was markedly reduced in the ganglionic eminences surrounding the lateral ventricles where mitotically active NPCs normally reside, in the RMS and in the OB (Figure 1F, H, J, L).
Gene_expression (expression) of survivin in lateral ventricles
6) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.20 Pain Relevance 0.12
The hypoplastic OB and absent RMS, in concert with reduced expression of NPC survivin in the SurvivinCamcre mice might be caused by decreased NPC proliferation, increased cell death, and/or deficits in migration.
Gene_expression (expression) of survivin associated with death
7) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.10 Pain Relevance 0.04
At E12.5, expression of survivin overlapped with Dlx1, a marker for mitotic cells in the MGE and LGE [24] (Figure 1A, D) and neurogenin 2 (Ngn2) [25], a marker for dividing precursors in the neocortex (Figure 1A, C).
Gene_expression (expression) of survivin in neocortex
8) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.21 Pain Relevance 0
During the first two postnatal weeks, survivin mRNA was also detected in granule cell precursors in the external germinal layer (EGL) of the developing cerebellum (Figure 2A).
Gene_expression (detected) of survivin mRNA in cerebellum
9) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0 Pain Relevance 0
At P7, survivin mRNA was detected in the SVZ, the RMS, the OB, and the dentate gyrus (DG) (Figure 2A, C, D, E).
Gene_expression (detected) of survivin mRNA in dentate gyrus
10) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0 Pain Relevance 0
In the adult brain, survivin expression remained restricted to proliferating and migrating precursor cells in the SVZ, the RMS, and the subgranular zone (SGZ) of the DG (Figure 2F, H).
Gene_expression (expression) of survivin in adult brain
11) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0 Pain Relevance 0
By E17.5, survivin was additionally expressed in the rostral migratory stream (RMS) and at the center of the olfactory bulb (OB) (Figure 1G, I, K).
Gene_expression (expressed) of survivin in olfactory bulb
12) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.16 Pain Relevance 0
At E12.5, survivin is widely expressed in the neurogenic region of the ventral and dorsal telencephalon.
Gene_expression (expressed) of survivin in ventral
13) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.34 Pain Relevance 0.16
However, similar to PCNA, not all DCX positive cells expressed survivin, indicating that survivin is restricted to a subpopulation of cells in the SVZ-RMS (not shown).
Gene_expression (expressed) of survivin
14) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0 Pain Relevance 0
Overall, these preliminary findings suggest that enhanced expression of NPC survivin may increase neurogenesis.


Gene_expression (expression) of survivin associated with neurodegenerative disease
15) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.36 Pain Relevance 0.11
Within these neurogenic regions, a subpopulation of NPCs continues to express survivin, which is downregulated once the cells differentiate into neurons.
Gene_expression (express) of survivin in neurons
16) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0 Pain Relevance 0.04
In situ hybridization using a probe against full length survivin allowed assessment of the spatiotemporal expression of survivin during embryonic development.
Gene_expression (expression) of survivin
17) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.30 Pain Relevance 0.03
In situ hybridization confirmed loss of survivin expression in the SVZ and RMS (Figure 2A, B, F, G).
Gene_expression (expression) of survivin
18) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.22 Pain Relevance 0.03
Thus, survivin expressing cells represent a subpopulation of the mitotically active cells.
Gene_expression (expressing) of survivin
19) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0 Pain Relevance 0
Mature neuronal marker NeuN [29] immunoreactivity did not overlap with survivin, consistent with the lack of survivin expression by mature neurons (Figure 2C-E).
Gene_expression (expression) of survivin in neuronal
20) Confidence 0.78 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0 Pain Relevance 0.03

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