INT11649

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Context Info
Confidence 0.59
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 13.94
Pain Relevance 10.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cytoplasm (Gpt)
Anatomy Link Frequency
liver 6
plasma 4
platelets 2
leaf 2
Gpt (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 193 100.00 Very High Very High Very High
Glutamate 1 100.00 Very High Very High Very High
ischemia 19 99.44 Very High Very High Very High
Infliximab 1 99.38 Very High Very High Very High
Inflammation 32 98.12 Very High Very High Very High
COX-2 inhibitor 2 90.32 High High
cva 3 88.72 High High
nud 1 87.48 High High
Pain 2 86.72 High High
cINOD 7 66.40 Quite High
Disease Link Frequency Relevance Heat
Overdose 6 99.98 Very High Very High Very High
Stress 15 99.88 Very High Very High Very High
Cancer 6 99.72 Very High Very High Very High
Necrosis 20 99.48 Very High Very High Very High
Cv Unclassified Under Development 19 99.44 Very High Very High Very High
Pressure And Volume Under Development 2 99.00 Very High Very High Very High
Injury 96 98.20 Very High Very High Very High
Pneumonia 1 98.12 Very High Very High Very High
Hepatotoxicity 57 98.08 Very High Very High Very High
Toxicity 35 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dosages of at least 12 mg/kg were required to prevent the increase in alanine transaminase (ALT) and only the 24 mg/kg hindered the appearance of histological lesions.
Negative_regulation (prevent) of Positive_regulation (increase) of alanine transaminase
1) Confidence 0.59 Published 1990 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2353130 Disease Relevance 0.40 Pain Relevance 0.39
However, when B6C3F1 mice were exposed to cold stress, the increase in plasma GPT activity induced by acetaminophen was significantly inhibited by 53% and 44%, respectively.
Negative_regulation (inhibited) of Positive_regulation (increase) of GPT in plasma associated with stress and paracetamol
2) Confidence 0.43 Published 1995 Journal Toxicol. Lett. Section Abstract Doc Link 8553366 Disease Relevance 0.50 Pain Relevance 0.52
Dosages of at least 12 mg/kg were required to prevent the increase in alanine transaminase (ALT) and only the 24 mg/kg hindered the appearance of histological lesions.
Negative_regulation (prevent) of Positive_regulation (increase) of ALT
3) Confidence 0.43 Published 1990 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2353130 Disease Relevance 0.40 Pain Relevance 0.39
As a result, pretreated with ASE prior to the administration of APAP significantly prevented the increases of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and tumor necrosis factor-alpha (TNF-alpha) levels in serum, and glutathione (GSH) depletion, malondialdehyde (MDA) accumulation in liver tissue.
Negative_regulation (prevented) of Positive_regulation (increases) of ALT in liver associated with necrosis, paracetamol and cancer
4) Confidence 0.42 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19801828 Disease Relevance 0.54 Pain Relevance 0.58
Intragastric administration of methoxsalen (125 mumol X kg-1), 30 min before that of acetaminophen (600 mg X kg-1 i.p.), decreased the formation of the mercapturate and cysteine conjugates of acetaminophen, the depletion of glutathione and the in vivo covalent binding of an acetaminophen metabolite to hepatic proteins and prevented the increase in serum glutamic-pyruvic transaminase activity, the appearance of liver lesions and mortality.
Negative_regulation (prevented) of Positive_regulation (increase) of glutamic-pyruvic transaminase in liver associated with paracetamol
5) Confidence 0.42 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3772810 Disease Relevance 0.24 Pain Relevance 0.65
However, a significant inhibition (p<0.05) in the elevation of AST and ALT was observed in mice that received UBG and GIBG compared with APAP-treated mice.
Negative_regulation (inhibition) of Positive_regulation (elevation) of ALT associated with paracetamol
6) Confidence 0.42 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19109935 Disease Relevance 0.69 Pain Relevance 0.77
Administration of L-carnitine significantly reduced AA-induced elevations in AST, ALT, TSA and MDA concentrations and increased GSH levels at all sampling points.
Negative_regulation (reduced) of Positive_regulation (elevations) of ALT associated with paracetamol
7) Confidence 0.41 Published 2007 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 17716880 Disease Relevance 0.73 Pain Relevance 1.08
Solanum alatum treatment (100 mg/kg, p.o.) decreased the elevation of serum alanine aminotransferase (ALT; GPT) and aspartate aminotransferase (AST; GOT) induced by acetaminophen (paracetamol) (600 mg/kg, i.p.) administration.
Negative_regulation (decreased) of Positive_regulation (elevation) of ALT associated with paracetamol
8) Confidence 0.41 Published 2000 Journal Am. J. Chin. Med. Section Abstract Doc Link 10794122 Disease Relevance 0.26 Pain Relevance 0.45
Reducing the dose of NAC or cysteamine by 50% greatly reduced their hepatoprotective effect while the co-administration of the reduced doses of NAC (250 mg/kg) and cysteamine (50 mg/kg) following acetaminophen overdose prevented elevation of serum ALT activity (39.2 +/- 1.17 and 32.5 +/- 5.63 U/mL at 12 and 24 h post-injection, p less than 0.001) and preserved normal mouse hepatic histology.
Negative_regulation (prevented) of Positive_regulation (elevation) of ALT associated with paracetamol and overdose
9) Confidence 0.40 Published 1992 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 1581851 Disease Relevance 0.30 Pain Relevance 0.48
Diltiazem (24 mg/kg) reduced the increase in ALT induced by 1.1 mg/kg of phalloidine by 58% (4460 +/- 317 U/mL v.s. 1852 +/- 339 U/mL; p less than 0.05).
Negative_regulation (reduced) of Positive_regulation (increase) of ALT
10) Confidence 0.38 Published 1990 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2353130 Disease Relevance 0.41 Pain Relevance 0.41
Diltiazem (24 mg/kg) reduced the increase in ALT induced by 1.1 mg/kg of phalloidine by 58% (4460 +/- 317 U/mL v.s. 1852 +/- 339 U/mL; p less than 0.05).
Negative_regulation (reduced) of Positive_regulation (induced) of ALT
11) Confidence 0.38 Published 1990 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2353130 Disease Relevance 0.42 Pain Relevance 0.41
P. niruri significantly reduced the elevated glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP) levels in the sera of toxicity induced mice, compared with the control group.
Negative_regulation (reduced) of Positive_regulation (elevated) of glutamate pyruvate transaminase associated with toxicity and glutamate
12) Confidence 0.37 Published 2006 Journal Phytother Res Section Abstract Doc Link 16718736 Disease Relevance 0.37 Pain Relevance 0.43
In mice, pretreatment with AC prior to the administration of CCl4 significantly prevented the increased serum enzymatic activity of ALT and AST as well as the formation of hepatic malondialdehyde.
Negative_regulation (prevented) of Positive_regulation (increased) of ALT
13) Confidence 0.33 Published 2009 Journal Food Chem. Toxicol. Section Abstract Doc Link 18984026 Disease Relevance 0.45 Pain Relevance 0.13
Pre-ischemic treatment of mice with DMPP significantly reduced ALT levels caused by 90 min of ischemia followed by 3 h of reperfusion.
Negative_regulation (reduced) of Positive_regulation (caused) of ALT associated with ischemia
14) Confidence 0.31 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 1.24 Pain Relevance 0.17
SDS significantly protected APAP-induced hepatotoxicity for SDS improved mouse survival rates better than NAC against a lethal dose of APAP and significantly blocked not only APAP-induced increases of AST, ALT, and TNF-alpha but also APAP-induced GSH depletion and MDA accumulation.
Negative_regulation (blocked) of Positive_regulation (increases) of ALT associated with paracetamol and hepatotoxicity
15) Confidence 0.29 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18670083 Disease Relevance 0.66 Pain Relevance 0.98
The concomitant administration of pentoxifylline (decreasing TNF-alpha secretion) and infliximab (trapping TNF-alpha) likewise attenuated the Jo2-mediated increase in TNF-alpha, the decrease in hepatic glutathione, and the increase in serum ALT activity 5 h after Jo2 administration.
Negative_regulation (attenuated) of Positive_regulation (increase) of ALT associated with infliximab
16) Confidence 0.28 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18572215 Disease Relevance 0.65 Pain Relevance 0.20
In the model of liver damage induced by acetaminophen of mice, injection of interleukin-1 beta (IL-1 beta, i.p. 50,000 U/kg) 1, 6 or 12 h before the administration of acetaminophen could reduce the leakages of GPT and GOT induced by acetaminophen, with the 12 h pretreatment being the most effective.
Negative_regulation (reduce) of Positive_regulation (induced) of GPT in liver associated with paracetamol and hepatotoxicity
17) Confidence 0.20 Published 1997 Journal Sheng Li Xue Bao Section Abstract Doc Link 9812850 Disease Relevance 0.17 Pain Relevance 0.57
Aqueous A. indica leaf extract (500 mg/kg, p.o.) significantly (P < 0.01) reduced these elevated levels of AST, ALT and gamma-GT.
Negative_regulation (reduced) of Positive_regulation (elevated) of ALT in leaf
18) Confidence 0.18 Published 2000 Journal Indian J. Physiol. Pharmacol. Section Abstract Doc Link 10919097 Disease Relevance 0.33 Pain Relevance 0.34
Furthermore, treatment with polaprezinc at 4 h before APAP administration suppressed the increase in plasma ALT activity (Nishida, unpublished data).
Negative_regulation (suppressed) of Positive_regulation (increase) of ALT in plasma associated with paracetamol
19) Confidence 0.17 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2803132 Disease Relevance 0.28 Pain Relevance 0.49
In 10 out of 11 patients in this study who were re-treated with IFN, IFN re-treatment might have helped to maintain a low ALT status or prevented further elevation of ALT, but a bigger patient population of IFN re-treated patients are required to establish this hypothesis.
Negative_regulation (prevented) of Positive_regulation (elevation) of ALT
20) Confidence 0.09 Published 2008 Journal Cancer Informatics Section Body Doc Link PMC2623298 Disease Relevance 1.46 Pain Relevance 0

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