INT116490

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Context Info
Confidence 0.68
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 3.86
Pain Relevance 5.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRPV1) transport (TRPV1) plasma membrane (TRPV1)
lipid metabolic process (TRPV1)
Anatomy Link Frequency
sensory neurons 2
SH-SY5Y 2
esophagus 2
head 2
reticulum 2
TRPV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 8 100.00 Very High Very High Very High
Kinase C 6 100.00 Very High Very High Very High
Analgesic 2 100.00 Very High Very High Very High
noradrenaline 2 100.00 Very High Very High Very High
qutenza 34 99.98 Very High Very High Very High
Inflammatory mediators 17 99.84 Very High Very High Very High
Inflammation 97 99.32 Very High Very High Very High
nociceptor 4 99.08 Very High Very High Very High
c fibre 3 98.60 Very High Very High Very High
Glutamate receptor 2 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 101 99.84 Very High Very High Very High
Nociception 24 95.88 Very High Very High Very High
Pain 11 93.60 High High
Ganglion Cysts 11 91.00 High High
Hyperalgesia 12 88.16 High High
Death 2 75.00 Quite High
Neuroblastoma 2 75.00 Quite High
Inflammatory Pain 1 61.28 Quite High
Arthritis 22 5.00 Very Low Very Low Very Low
Esophageal Disease 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was found that the capacitation promoted the translocation of TRPV1 from the post-acrosomal to the apical region of sperm head.
Positive_regulation (promoted) of Localization (translocation) of TRPV1 in head
1) Confidence 0.68 Published 2010 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 20219627 Disease Relevance 0 Pain Relevance 0.31
TRPV1-induced release of inflammatory mediators in the human esophagus
Positive_regulation (induced) of Localization (release) of TRPV1 in esophagus associated with inflammatory mediators
2) Confidence 0.48 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.28 Pain Relevance 0.64
As an indicator of TRPV1 mediated ROS released into the supernatant, ROS metabolites 2,5-DHBA and 2,3-DHBA were trapped with salicylic acid [50] and the samples analyzed by high performance liquid chromatography with electrochemical detection (HPLC-ECD).
Positive_regulation (mediated) of Localization (released) of TRPV1
3) Confidence 0.47 Published 2010 Journal Mol Pain Section Body Doc Link PMC2924298 Disease Relevance 0 Pain Relevance 0.11
Botulinum neurotoxin A blocked the TRPV1 membrane translocation induced by PKC that was activated with a phorbol ester or the metabotropic glutamate receptor mGluR5.
Positive_regulation (activated) of Localization (translocation) of TRPV1 associated with kinase c and glutamate receptor
4) Confidence 0.46 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15066994 Disease Relevance 0.14 Pain Relevance 0.63
Capsaicin stimulated the release of pre-labelled [(3)H]noradrenaline from monolayers of SH-SY5Y(hTRPV1) cells with an EC(50) of 0.6 nmol/L indicating amplification between [Ca(2+)](i) and release.
Positive_regulation (stimulated) of Localization (release) of hTRPV1 in SH-SY5Y associated with qutenza and noradrenaline
5) Confidence 0.40 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17442052 Disease Relevance 0.22 Pain Relevance 0.75
Furthermore, CB1 and TRPV1 (transient potential receptor vanilloid subtype-1) co-localization was increased from 41% before inflammation to 67% two days after inflammation.
Positive_regulation (increased) of Localization (co-localization) of TRPV1 associated with inflammation
6) Confidence 0.29 Published 2006 Journal Pain Section Abstract Doc Link 16709443 Disease Relevance 1.25 Pain Relevance 1.10
Direct depletion of calcium via activation of endoplasmic reticulum-localized vanilloid receptor 1 triggered store operated calcium entry.
Positive_regulation (activation) of Localization (reticulum-localized) of vanilloid receptor 1 in reticulum
7) Confidence 0.25 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 14963041 Disease Relevance 0.28 Pain Relevance 0.35
Furthermore, CB1 and TRPV1 (transient potential receptor vanilloid subtype-1) co-localization was increased from 41% before inflammation to 67% two days after inflammation.
Positive_regulation (increased) of Localization (co-localization) of transient potential receptor vanilloid subtype-1 associated with inflammation
8) Confidence 0.18 Published 2006 Journal Pain Section Abstract Doc Link 16709443 Disease Relevance 1.25 Pain Relevance 1.09
Activation of TRPV1 mediates calcitonin gene-related peptide release, which excites trigeminal sensory neurons and is attenuated by a retargeted botulinum toxin with anti-nociceptive potential.
Positive_regulation (Activation) of Localization (release) of TRPV1 in sensory neurons associated with nociception, analgesic and calcitonin gene-related peptide
9) Confidence 0.12 Published 2009 Journal J. Neurosci. Section Title Doc Link 19369567 Disease Relevance 0.44 Pain Relevance 0.69

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