INT116498

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 3.08
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
peritoneal fluid 4
T-cell 2
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 86 99.98 Very High Very High Very High
antagonist 2 98.56 Very High Very High Very High
endometriosis 4 95.04 Very High Very High Very High
pain pelvic 4 93.88 High High
Inflammation 155 92.32 High High
cytokine 77 87.12 High High
Potency 6 85.16 High High
methotrexate 24 84.32 Quite High
headache 2 84.20 Quite High
agonist 14 75.00 Quite High
Disease Link Frequency Relevance Heat
Toxicity 1 95.72 Very High Very High Very High
Endometriosis (extended) 4 95.04 Very High Very High Very High
Reprotox - General 3 8 93.88 High High
INFLAMMATION 167 92.32 High High
Headache 2 84.20 Quite High
Nasal Obstruction 1 83.04 Quite High
Necrosis 5 82.80 Quite High
Cancer 5 82.44 Quite High
Disease 37 80.48 Quite High
Congenital Anomalies 1 79.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In both NS and betamethasone patients, the levels of IL-1beta and IL-8 had significantly decreased by the 3rd and 2nd weeks after therapy, respectively.
Negative_regulation (decreased) of Negative_regulation (levels) of IL-1beta
1) Confidence 0.41 Published 2005 Journal Eur Arch Otorhinolaryngol Section Abstract Doc Link 14963719 Disease Relevance 0.39 Pain Relevance 0.17
OBJECTIVE: To evaluate the levels of interleukin-1beta (IL1beta) and its inhibitory soluble interleukin-1 receptor type II (IL1R2) in the peritoneal fluid (PF) of normal women and patients with endometriosis suffering from pelvic pain and infertility.
Negative_regulation (evaluate) of Negative_regulation (levels) of interleukin-1beta in peritoneal fluid associated with endometriosis, reprotox - general 3 and pain pelvic
2) Confidence 0.41 Published 2008 Journal Fertil. Steril. Section Abstract Doc Link 17919610 Disease Relevance 0.51 Pain Relevance 0.25
OBJECTIVE: To evaluate the levels of interleukin-1beta (IL1beta) and its inhibitory soluble interleukin-1 receptor type II (IL1R2) in the peritoneal fluid (PF) of normal women and patients with endometriosis suffering from pelvic pain and infertility.
Negative_regulation (evaluate) of Negative_regulation (levels) of IL1 in peritoneal fluid associated with endometriosis, reprotox - general 3 and pain pelvic
3) Confidence 0.41 Published 2008 Journal Fertil. Steril. Section Abstract Doc Link 17919610 Disease Relevance 0.51 Pain Relevance 0.25
We found that SB203580 and SP600125 – specific inhibitors of the MAPKs p38 and JNK, respectively – almost completely abolished the IL-1-mediated downregulation of PPAR?
Negative_regulation (abolished) of Negative_regulation (downregulation) of IL-1-mediated
4) Confidence 0.24 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.11 Pain Relevance 0.06
This follows a pattern seen with other botanical extracts or nutraceuticals, which note reduced but incomplete blockade of IL-1?
Negative_regulation (reduced) of Negative_regulation (blockade) of IL-1
5) Confidence 0.15 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.15 Pain Relevance 0.03
Furthermore, BOL-303242-X inhibited IL-1ß-induced decreases in I?
Negative_regulation (inhibited) of Negative_regulation (decreases) of IL-1
6) Confidence 0.15 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2790480 Disease Relevance 0.53 Pain Relevance 0.48
Our data indicate that both BOL-303242-X and dexamethasone inhibit IL-1ß-induced reduction in I?
Negative_regulation (inhibit) of Negative_regulation (reduction) of IL-1 associated with dexamethasone
7) Confidence 0.15 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 0.47 Pain Relevance 0.30
Previous studies of a TNF inhibitor plus an IL-1 inhibitor or a T-cell costimulatory molecule antagonist showed no enhancement in Efficacy but definite increases in toxicity (Kavanaugh et al 2004).
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of IL-1 in T-cell associated with toxicity and antagonist
8) Confidence 0.06 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621374 Disease Relevance 0.42 Pain Relevance 0.16

General Comments

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