INT11650

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1991
Last Reported 2010
Negated 5
Speculated 3
Reported most in Abstract
Documents 122
Total Number 126
Disease Relevance 69.15
Pain Relevance 30.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cytoplasm (Gpt)
Anatomy Link Frequency
liver 13
plasma 8
blood 8
body 4
hepatocytes 2
Gpt (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 440 100.00 Very High Very High Very High
Glutamate 14 100.00 Very High Very High Very High
methotrexate 9 100.00 Very High Very High Very High
Inflammation 331 99.90 Very High Very High Very High
alcohol 55 99.56 Very High Very High Very High
Nicotine 80 99.40 Very High Very High Very High
diclofenac 47 99.16 Very High Very High Very High
ischemia 88 98.88 Very High Very High Very High
cINOD 75 98.72 Very High Very High Very High
Ultiva 7 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatotoxicity 227 100.00 Very High Very High Very High
Hepatocellular Cancer 548 99.92 Very High Very High Very High
Infection 102 99.92 Very High Very High Very High
INFLAMMATION 420 99.90 Very High Very High Very High
Injury 752 99.86 Very High Very High Very High
Hepatitis 243 99.84 Very High Very High Very High
Hepatitis B Virus Infection 173 99.84 Very High Very High Very High
Necrosis 150 99.60 Very High Very High Very High
Death 97 99.58 Very High Very High Very High
Viremia 4 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, concomitant administration of NAC and cimetidine produced a 100% survival rate and a marked reduction in plasma GOT and GPT activities to within the normal range, while significantly raising hepatic GSH concentrations to values close to those measured in saline-treated control animals.
Negative_regulation (reduction) of GPT in plasma
1) Confidence 0.59 Published 1997 Journal Toxicology Section Abstract Doc Link 9231700 Disease Relevance 0.13 Pain Relevance 0.38
None of the NO synthase inhibitors reduced serum ALT levels.
Negative_regulation (reduced) of ALT
2) Confidence 0.57 Published 2002 Journal Nitric Oxide Section Abstract Doc Link 11890740 Disease Relevance 0.36 Pain Relevance 0.68
However, no additional reduction in plasma levels of AST and ALT was observed when sodium sulphate was co-administered with NAC.
Neg (no) Negative_regulation (reduction) of ALT in plasma
3) Confidence 0.56 Published 1998 Journal Inflammopharmacology Section Abstract Doc Link 17657622 Disease Relevance 0.15 Pain Relevance 0.72
Depletion of neutrophils by in vivo treatment with anti-Gr-1 antibody (RB6-8C5) significantly protected mice against APAP-induced liver injury, as evidenced by markedly reduced serum ALT levels, centrilobular hepatic necrosis, and improved mouse survival.
Negative_regulation (reduced) of ALT in neutrophils associated with necrosis, paracetamol and injury
4) Confidence 0.52 Published 2006 Journal Hepatology Section Abstract Doc Link 16729305 Disease Relevance 0.82 Pain Relevance 0.76
The results have shown that PGI2 exibits a strong hepatoprotective effect when it was given to mice either before or after APAP (both increase of survival of mice and decrease of plasma ALT levels were statistical significant).
Negative_regulation (decrease) of ALT in plasma associated with paracetamol
5) Confidence 0.51 Published 2009 Journal Coll Antropol Section Abstract Doc Link 20120521 Disease Relevance 0.15 Pain Relevance 0.91
P. niruri significantly reduced the elevated glutamate pyruvate transaminase (GPT) and alkaline phosphatase (ALP) levels in the sera of toxicity induced mice, compared with the control group.
Negative_regulation (reduced) of glutamate pyruvate transaminase associated with toxicity and glutamate
6) Confidence 0.51 Published 2006 Journal Phytother Res Section Abstract Doc Link 16718736 Disease Relevance 0.37 Pain Relevance 0.43
V-PYRRO/NO administration dramatically reduced acetaminophen-induced hepatotoxicity in a dose- and time-dependent manner, as evidenced by reduced serum alanine aminotransferase (ALT) activity, reduced hepatic congestion, apoptosis, and improved hepatocellular pathology.
Negative_regulation (reduced) of ALT associated with paracetamol, hepatotoxicity and apoptosis
7) Confidence 0.50 Published 2003 Journal Hepatology Section Abstract Doc Link 12540782 Disease Relevance 0.68 Pain Relevance 0.64
A similar pattern was observed in the pre-treated group 4 h after the administration of paracetamol with a reduction in serum levels of ALT, aspartate aminotransferase and alkaline phosphatase enzymes by 65.04, 55.79 and 45.75% respectively (P < 0.001).
Negative_regulation (reduction) of ALT associated with paracetamol
8) Confidence 0.48 Published 2003 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 14607024 Disease Relevance 0.22 Pain Relevance 0.38
Asteracantha reduced the alanine aminotransferase (ALT) level by 69.32% (P < 0.001) and increased the liver reduced glutathione level by 64.65% (P < 0.001) in the pre-treated group, 4 days after the administration of CCl4.
Negative_regulation (reduced) of ALT in liver
9) Confidence 0.48 Published 2003 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 14607024 Disease Relevance 0.25 Pain Relevance 0.33
If methotrexate is administered in conjunction with either nicotinamide or methionine, the rise in the death rate and in GOT and GPT activities associated with methotrexate application is markedly reduced.
Negative_regulation (reduced) of GPT associated with methotrexate and death
10) Confidence 0.43 Published 1999 Journal Gen. Pharmacol. Section Abstract Doc Link 10461859 Disease Relevance 0.35 Pain Relevance 0.49
Mice fed the "Western-style" diet were protected from APAP hepatotoxicity as evidenced by 89% decrease in ALT levels and less centrilobular injury, which was associated with 42% decrease in CYP2E1 mRNA levels.
Negative_regulation (decrease) of ALT
11) Confidence 0.42 Published 2006 Journal Microcirculation Section Body Doc Link 16393943 Disease Relevance 0.07 Pain Relevance 0
With pre-treatment with either TFA or Vitamin C, there was an obvious dose-dependent decrease in ALT levels and the area of hepatocellular necrosis.
Negative_regulation (decrease) of ALT in TFA
12) Confidence 0.42 Published 2001 Journal Zhongguo Zhong Yao Za Zhi Section Body Doc Link 12776364 Disease Relevance 0 Pain Relevance 0
TQ supplementation dramatically reduced acetaminophen-induced hepatotoxicity, in a dose-dependent manner, as evidenced by decreased serum alanine aminotransferase (ALT) activities.
Negative_regulation (decreased) of ALT associated with paracetamol and hepatotoxicity
13) Confidence 0.42 Published 2010 Journal Food Chem. Toxicol. Section Abstract Doc Link 20561950 Disease Relevance 0.26 Pain Relevance 0.71
Pre-ischemic treatment of mice with DMPP significantly reduced ALT levels caused by 90 min of ischemia followed by 3 h of reperfusion.
Negative_regulation (reduced) of ALT associated with ischemia
14) Confidence 0.42 Published 2006 Journal BMC Clin Pathol Section Body Doc Link PMC1382240 Disease Relevance 1.23 Pain Relevance 0.17
The acetaminophen-induced release of both GOT and GPT from injured liver cells could be inhibited in a dose-dependent manner, when mice were injected additionally either with increasing amounts (from (25 mg/kg to 100 mg/kg i.p.) of the PARP-inhibitor nicotinamide, with increasing amounts (from 25 mg/kg to 100 mg/kg i.p.) of the antioxidant N-acetylcysteine, or with increasing amounts (from 50 mg/kg to 300 mg/kg i.p.) of the amino acid L-methionine. 4.
Negative_regulation (inhibited) of GPT in liver associated with paracetamol
15) Confidence 0.42 Published 1997 Journal Gen. Pharmacol. Section Abstract Doc Link 9013204 Disease Relevance 0.25 Pain Relevance 0.51
ALT and GGT were not significantly decreased compared to their corresponding controls.
Neg (not) Negative_regulation (decreased) of ALT
16) Confidence 0.41 Published 2002 Journal Arzneimittelforschung Section Abstract Doc Link 12040972 Disease Relevance 1.14 Pain Relevance 0.30
Administration of cysteamine (100 mg/kg) or NAC (500 mg/kg) significantly reduced serum ALT activity (p less than 0.001).
Negative_regulation (reduced) of ALT
17) Confidence 0.39 Published 1992 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 1581851 Disease Relevance 0.24 Pain Relevance 0.47
At optimal time point after LPS injection, the MCS group and control group (n = 8) serum was separated from whole blood by centrifugation at 15,000 rpm for 10 min at 4°C, and the serum alanine transaminase (ALT) was measured using Vet Scan Rotar Profiler (ABAXIS, Inc.
Negative_regulation (measured) of serum alanine transaminase in blood
18) Confidence 0.38 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386525 Disease Relevance 0 Pain Relevance 0
At optimal time point after LPS injection, the MCS group and control group (n = 8) serum was separated from whole blood by centrifugation at 15,000 rpm for 10 min at 4°C, and the serum alanine transaminase (ALT) was measured using Vet Scan Rotar Profiler (ABAXIS, Inc.
Negative_regulation (measured) of ALT in blood
19) Confidence 0.38 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386525 Disease Relevance 0 Pain Relevance 0
BUN and serum creatinine, ALT and AST levels which were increased significantly following AA treatment decreased significantly after pretreatment with either vitamin E, melatonin or NAC; however, they were not reduced to control levels.
Negative_regulation (decreased) of ALT associated with paracetamol
20) Confidence 0.38 Published 2003 Journal J. Pineal Res. Section Abstract Doc Link 12823615 Disease Relevance 0.51 Pain Relevance 0.68

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox