INT11652

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Context Info
Confidence 0.58
First Reported 1992
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 24.96
Pain Relevance 6.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rara) nucleus (Rara) enzyme binding (Rara)
DNA binding (Rara) transcription factor binding (Rara) cytoplasm (Rara)
Anatomy Link Frequency
spinal cord 3
peripheral nerve 2
immune cells 1
peripheral nervous system 1
Rara (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 181 100.00 Very High Very High Very High
Inflammation 925 99.98 Very High Very High Very High
Spinal cord 576 99.72 Very High Very High Very High
Peripheral nerve injury 36 99.72 Very High Very High Very High
lidocaine 5 99.40 Very High Very High Very High
Peripheral nervous system 108 99.16 Very High Very High Very High
Central nervous system 307 97.40 Very High Very High Very High
Sciatic nerve 54 95.92 Very High Very High Very High
Arthritis 38 94.84 High High
c fibre 5 94.32 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1422 100.00 Very High Very High Very High
Cancer 197 100.00 Very High Very High Very High
INFLAMMATION 1204 99.98 Very High Very High Very High
Targeted Disruption 68 99.76 Very High Very High Very High
Frailty 360 99.72 Very High Very High Very High
Heart Rate Under Development 20 99.68 Very High Very High Very High
Keloid Scars 19 99.68 Very High Very High Very High
Injury 399 99.64 Very High Very High Very High
Nervous System Injury 72 99.28 Very High Very High Very High
Emphysema 49 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To that end, demethylation and re-expression of tumor suppressor genes, estrogen receptor, and p16, RAR?
Gene_expression (expression) of RAR associated with cancer
1) Confidence 0.58 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.63 Pain Relevance 0.03
Within this class of so-called "non-toxic and orally administered agents", there is the green tea major polyphenol (-)-epigallocatechin-3-gallate (EGCG) that demonstrated to be an effective DNMT activity inhibitor at micromolar concentrations and that was able to demethylate and reactivate expression of several tumor suppressor genes such as p16, RAR-?
Gene_expression (expression) of RAR associated with cancer
2) Confidence 0.58 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.69 Pain Relevance 0
RAR/RXR signaling is involved in inflammation
Gene_expression (signaling) of RAR associated with inflammation
3) Confidence 0.44 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.49 Pain Relevance 0.53
findings that indicate an anti-inflammatory role of RAR/RXR signaling, it was
Gene_expression (role) of RAR associated with inflammation
4) Confidence 0.44 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.47 Pain Relevance 0.43
RAR/RXR signaling after spinal cord injury
Gene_expression (/) of RAR in spinal cord associated with spinal cord
5) Confidence 0.44 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.89 Pain Relevance 0.18
RAR/RXR signaling after peripheral nerve injury
Gene_expression (signaling) of RAR in peripheral nerve associated with nervous system injury and peripheral nerve injury
6) Confidence 0.44 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.14 Pain Relevance 0.18
stimulating agents, all-trans RA, 9-cis RA, and an RAR agonist,
Gene_expression (agonist) of RAR associated with rheumatoid arthritis and agonist
7) Confidence 0.44 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.37 Pain Relevance 0.40
Manipulation of RAR/RXR signaling in the peripheral nervous system
Gene_expression (/) of RAR in peripheral nervous system associated with peripheral nervous system
8) Confidence 0.44 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.46 Pain Relevance 0.32
About 500 genes have been suggested to be regulated by RAR/RXR
Gene_expression (/) of RAR
9) Confidence 0.44 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.75 Pain Relevance 0.15
They observed that the RAR?
Gene_expression (observed) of RAR
10) Confidence 0.44 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.39 Pain Relevance 0.36
RAR/RXR signaling after spinal cord injury
Gene_expression (signaling) of RAR in spinal cord associated with spinal cord
11) Confidence 0.44 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.89 Pain Relevance 0.18
findings that indicate an anti-inflammatory role of RAR/RXR signaling, it was
Gene_expression (signaling) of RAR associated with inflammation
12) Confidence 0.44 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.47 Pain Relevance 0.43
findings that indicate an anti-inflammatory role of RAR/RXR signaling, it was
Gene_expression (/) of RAR associated with inflammation
13) Confidence 0.44 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.47 Pain Relevance 0.43
RAR/RXR signaling is involved in inflammation
Gene_expression (/) of RAR associated with inflammation
14) Confidence 0.44 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.48 Pain Relevance 0.53
with RAR?
Gene_expression (with) of RAR
15) Confidence 0.44 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.99 Pain Relevance 0.11
RA/RAR?
Gene_expression (/) of RAR associated with rheumatoid arthritis
16) Confidence 0.44 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.02 Pain Relevance 0.12
RAR/RXR signaling after peripheral nerve injury
Gene_expression (/) of RAR in peripheral nerve associated with nervous system injury and peripheral nerve injury
17) Confidence 0.44 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.14 Pain Relevance 0.18
Intravenous lidocaine (1 mg.kg(-1) or 2 mg.kg(-1)) produced a suppression of SAR activity but not of RAR activity.
Neg (not) Gene_expression (produced) of RAR associated with lidocaine
18) Confidence 0.40 Published 1992 Journal J Anesth Section Abstract Doc Link 15278511 Disease Relevance 0.08 Pain Relevance 0.44
expression of RAR?
Gene_expression (expression) of RAR
19) Confidence 0.39 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.17 Pain Relevance 0.46
protein levels of RAR?
Gene_expression (levels) of RAR
20) Confidence 0.39 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.06 Pain Relevance 0.16

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