INT116528

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 1
Speculated 5
Reported most in Abstract
Documents 106
Total Number 113
Disease Relevance 86.13
Pain Relevance 12.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HMOX1) endoplasmic reticulum (HMOX1) enzyme binding (HMOX1)
transmembrane transport (HMOX1) signal transducer activity (HMOX1) cytosol (HMOX1)
Anatomy Link Frequency
monocytes 11
lung 5
macrophages 3
leukocytes 3
intestinal epithelium 2
HMOX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 6 99.92 Very High Very High Very High
withdrawal 24 99.86 Very High Very High Very High
Inflammation 2032 99.32 Very High Very High Very High
rheumatoid arthritis 587 99.30 Very High Very High Very High
Infliximab 112 98.96 Very High Very High Very High
cva 41 98.88 Very High Very High Very High
cINOD 90 98.70 Very High Very High Very High
Inflammatory response 475 98.68 Very High Very High Very High
Abeta 5 98.42 Very High Very High Very High
ischemia 170 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 489 100.00 Very High Very High Very High
Disease 5006 99.96 Very High Very High Very High
Synovitis 3 99.88 Very High Very High Very High
Brain Injury 202 99.84 Very High Very High Very High
Hemophagocytic Lymphohistiocytosis 60 99.70 Very High Very High Very High
Shock 242 99.60 Very High Very High Very High
Atherosclerosis 43 99.60 Very High Very High Very High
Rheumatic Diseases 224 99.56 Very High Very High Very High
Inflammatory Bowel Disease 672 99.54 Very High Very High Very High
Cerebrovascular Disease 4 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, naproxen (a non-selective NSAID) and rofecoxib (a selective inhibitor of COX-2), did not affect HO-1 expression.
Gene_expression (expression) of HO-1 associated with cinod
1) Confidence 0.78 Published 2005 Journal Eur J Pharm Sci Section Abstract Doc Link 15911218 Disease Relevance 0.07 Pain Relevance 0.18
Exposure to either PPI resulted in a strong induction of HO-1 expression on mRNA and protein level, and led to an increased activity of this enzyme.
Gene_expression (expression) of HO-1
2) Confidence 0.78 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16712795 Disease Relevance 0.18 Pain Relevance 0.06
In human umbilical vein and aortic endothelial cells, 24-48 h treatment with celecoxib induced HO-1 mRNA and protein expression and increased HO-1 enzyme activity.
Gene_expression (expression) of HO-1 in endothelial cells
3) Confidence 0.77 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 20083195 Disease Relevance 0.41 Pain Relevance 0.35
The modulation of HO-1 gene expression in LDL-C receptor-deficient mice influence the progression of atherosclerosis [17], and mice treated with the HO-1 inducer exhibited reduced atherosclerotic lesion formation.
Gene_expression (expression) of HO-1 gene associated with atherosclerosis
4) Confidence 0.77 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2841098 Disease Relevance 1.16 Pain Relevance 0.04
Two studies focused HO-1 mocroglia/macrophage and cerebrovascular disease speculated the prolong expression of HO-1 in traumatic brain injury, cerebral infarction and aneurysms [7,10].
Gene_expression (expression) of HO-1 in brain associated with cerebrovascular disease, aneurism, cva and brain injury
5) Confidence 0.77 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2841098 Disease Relevance 1.73 Pain Relevance 0.18
Vascular proliferation was inhibited by transferring HO-1 gene[18].
Gene_expression (transferring) of HO-1 gene
6) Confidence 0.77 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2841098 Disease Relevance 1.03 Pain Relevance 0.03
Overexpression of HO-1 in arterial walls reduces lesion formation as well as intimal hyperplasia subsequent to vascular injury, supporting its vasoprotective function [17-19].
Gene_expression (Overexpression) of HO-1 associated with vasculitis and hyperplasia
7) Confidence 0.77 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2841098 Disease Relevance 1.64 Pain Relevance 0.18
Our data support the hypothesis that the expression of the enzyme is defective in lung cancer tissue and are in agreement with a recent study [23] showing reduced HO-1 expression (by IHC methods) in the alveolar macrophages of patients with NSCLC, as compared to controls.
Gene_expression (expression) of HO-1 in lung associated with lung cancer and non-small-cell lung cancer
8) Confidence 0.70 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2911612 Disease Relevance 0.63 Pain Relevance 0
The present study shows that the expression levels of genes displaying antioxidant and cytoprotective properties, such as SOD-1, SOD-2, and HO-1, are depressed in lung cancer as compared to the unaffected lung tissue.
Gene_expression (expression) of HO-1 in lung associated with lung cancer
9) Confidence 0.70 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2911612 Disease Relevance 0.46 Pain Relevance 0
Increased HO-1 and ferritin expression as well as endothelial protection occurred at micromolar concentrations of PETriN which are well within the range of plasma or tissue levels that can be expected during oral therapy.
Gene_expression (expression) of HO-1 in plasma
10) Confidence 0.68 Published 2004 Journal Herz Section Abstract Doc Link 14968347 Disease Relevance 0.30 Pain Relevance 0.03
The present study demonstrates that the active PETN metabolite PETriN stimulates protein expression of the antioxidant defense protein heme oxygenase-1 (HO-1; Figures 1 and 2).
Gene_expression (expression) of heme oxygenase-1
11) Confidence 0.68 Published 2004 Journal Herz Section Abstract Doc Link 14968347 Disease Relevance 0.37 Pain Relevance 0.14
The present study demonstrates that the active PETN metabolite PETriN stimulates protein expression of the antioxidant defense protein heme oxygenase-1 (HO-1; Figures 1 and 2).
Gene_expression (expression) of HO-1
12) Confidence 0.68 Published 2004 Journal Herz Section Abstract Doc Link 14968347 Disease Relevance 0.37 Pain Relevance 0.14
AZD3582 increases heme oxygenase-1 expression and antioxidant activity in vascular endothelial and gastric mucosal cells.
Gene_expression (expression) of oxygenase-1
13) Confidence 0.68 Published 2005 Journal Eur J Pharm Sci Section Title Doc Link 15911218 Disease Relevance 0.06 Pain Relevance 0.17
This effect was abrogated in the presence of the heme oxygenase-1 (HO-1) inhibitor ZnBG.
Gene_expression (presence) of HO-1
14) Confidence 0.67 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16712795 Disease Relevance 0.19 Pain Relevance 0.06
This effect was abrogated in the presence of the heme oxygenase-1 (HO-1) inhibitor ZnBG.
Gene_expression (presence) of heme oxygenase-1
15) Confidence 0.67 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16712795 Disease Relevance 0.19 Pain Relevance 0.06
The functional significance of HO-1 induction was revealed by celecoxib-mediated inhibition of VCAM-1 expression, a response reversed by the HO-1 antagonist zinc protoporphyrin.
Gene_expression (induction) of HO-1 associated with antagonist
16) Confidence 0.67 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 20083195 Disease Relevance 0.30 Pain Relevance 0.43
GLNVA also suppressed accumulation of iROS and up-regulated heme oxygenase-1 expression. 6-OHDA-induced overexpression of nNOS, iNOS, COX-2, and gp91(phox) was also reduced by GLNVA.
Gene_expression (expression) of heme oxygenase-1
17) Confidence 0.65 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17855475 Disease Relevance 0.65 Pain Relevance 0.16
In our previous study [26] we demonstrated that TNF enhances HO-1 mRNA degradation, resulting in a reduction in HO-1 expression in human monocytes.
Gene_expression (expression) of HO-1 in monocytes
18) Confidence 0.60 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.36 Pain Relevance 0.03
In our previous study [26] we showed that TNF suppresses HO-1 expression levels in human peripheral monocytes, thereby accelerating inflammatory responses; this suggests that excessive TNF levels contribute to defective HO-1 expression.
Gene_expression (expression) of HO-1 in monocytes associated with inflammatory response
19) Confidence 0.60 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.08 Pain Relevance 0.12
The data suggest that activation signals through essentially over-expressed TLR4 cause reduction in HO-1 expression in peripheral blood mononuclear cells (PBMC), resulting in an augmentation of inflammatory responses in BD.


Gene_expression (expression) of HO-1 in mononuclear cells associated with inflammatory response and disease
20) Confidence 0.60 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.58 Pain Relevance 0.42

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