INT116529

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Context Info
Confidence 0.47
First Reported 2004
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 10
Total Number 13
Disease Relevance 15.38
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HMOX1) endoplasmic reticulum (HMOX1) enzyme binding (HMOX1)
transmembrane transport (HMOX1) signal transducer activity (HMOX1) cytosol (HMOX1)
Anatomy Link Frequency
monocytes 1
endothelial cells 1
central nervous system 1
HMOX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 31 99.32 Very High Very High Very High
epidural 3 96.92 Very High Very High Very High
Spinal cord 3 94.08 High High
Central nervous system 19 93.44 High High
cytokine 25 88.80 High High
Inflammation 32 88.44 High High
Infliximab 2 87.20 High High
Osteoarthritis 6 81.12 Quite High
tolerance 6 80.96 Quite High
spinal inflammation 6 79.84 Quite High
Disease Link Frequency Relevance Heat
Malaria 228 100.00 Very High Very High Very High
Disease 186 100.00 Very High Very High Very High
Heterotopic Ossification 75 100.00 Very High Very High Very High
Diabetes Mellitus 52 99.84 Very High Very High Very High
Coronary Artery Disease 49 99.48 Very High Very High Very High
Injury 43 99.40 Very High Very High Very High
Cv General 3 Under Development 29 99.32 Very High Very High Very High
Stress 34 99.20 Very High Very High Very High
Stroke 256 98.92 Very High Very High Very High
Nicotine Addiction 36 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The findings suggest that genetic characteristics of the HO-1 gene may interact with the oxidative stress conditions to contribute to the development of ischemic stroke.
HO-1 gene Binding (interact) of associated with stress and stroke
1) Confidence 0.47 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2841098 Disease Relevance 1.09 Pain Relevance 0.05
Additionally, PETriN enhanced the enzymatic activity of HO-1 measured as formation of the HO-1 metabolites bilirubin (Figure 3) and carbon monoxide (Figure 4) in lysates from endothelial cells.
HO-1 Binding (formation) of in endothelial cells
2) Confidence 0.42 Published 2004 Journal Herz Section Abstract Doc Link 14968347 Disease Relevance 0.41 Pain Relevance 0.13
Chen and his coauthors have shown a protection of HO-1 genotype in diabetic CAD patients with at least 1 coronary narrowing (>75%) and in restenosis patients after coronary stenting [24,35].
HO-1 genotype Binding (protection) of associated with coronary artery disease, cardiovascular disease and diabetes mellitus
3) Confidence 0.37 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2841098 Disease Relevance 1.59 Pain Relevance 0.07
We also aimed to explore the interaction of the HO-1 genotype and above risk factors on ischemic stroke.


HO-1 genotype Binding (interaction) of associated with stroke
4) Confidence 0.35 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2841098 Disease Relevance 2.16 Pain Relevance 0.04
Although the neuroprotective effect and the ability of reduced infarct size of HO-1 have been shown [32], the only study focused on recurrent and first ischemic cerebrovascular events still not reported a significant association between HO-1 promoter polymorphism and stroke [3].
HO-1 Binding (association) of associated with stroke and cva
5) Confidence 0.35 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2841098 Disease Relevance 1.79 Pain Relevance 0.05
Because our previous study demonstrated bidirectory interactions between HO-1 and TNF [26], we also examined effects of HO-1 upregulation on TLR levels in monocytes.
HO-1 Binding (interactions) of in monocytes
6) Confidence 0.28 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.21 Pain Relevance 0.04
Therefore, it may be possible that the linkage of cadmium exposure and susceptibility to malaria disease is through binding of cadmium to CdRE of the HO-1 gene.
HO-1 gene Binding (binding) of associated with malaria and disease
7) Confidence 0.19 Published 2010 Journal Malar J Section Body Doc Link PMC2949743 Disease Relevance 1.04 Pain Relevance 0.09
In this study, the association between malaria disease pathogenicity/severity and (GT)n repeat polymorphism in the promoter region of the inducible HO-1 including the effect of cadmium exposure (potent inducer of HO-1 transcription) as well as polymorphism of TNF were investigated.


HO-1 Binding (association) of associated with malaria and disease
8) Confidence 0.14 Published 2010 Journal Malar J Section Abstract Doc Link PMC2949743 Disease Relevance 1.51 Pain Relevance 0.09
When data were combined for all ethnic groups, no association between malaria disease severity and HO-1 genotype was observed.


HO-1 Neg (no) Binding (genotype) of associated with malaria and disease
9) Confidence 0.14 Published 2010 Journal Malar J Section Body Doc Link PMC2949743 Disease Relevance 0.61 Pain Relevance 0
When data were combined for all ethnic groups, no association between malaria disease severity and HO-1 genotype was observed.


HO-1 Neg (no) Binding (association) of associated with malaria and disease
10) Confidence 0.14 Published 2010 Journal Malar J Section Body Doc Link PMC2949743 Disease Relevance 0.72 Pain Relevance 0
There are three recognized etiologies of HO: traumatic, neurogenic, and genetic.
HO Binding (recognized) of associated with heterotopic ossification
11) Confidence 0.02 Published 2008 Journal Patient Saf Surg Section Abstract Doc Link PMC2584001 Disease Relevance 0.97 Pain Relevance 0.12
There are three recognized etiologies of HO: (1) traumatic – following fractures, dislocations, or operative procedures, (2) neurogenic – occurring after closed head injuries, insults to the spinal cord, or central nervous system infections, and (3) genetic (i.e. myositis ossificans progressiva – a rare, autosomal dominant disease) [1,2].
HO Binding (recognized) of in central nervous system associated with fibrodysplasia ossificans progressiva, central nervous system, disease, closed head injuries, dislocations, heterotopic ossification and spinal cord
12) Confidence 0.02 Published 2008 Journal Patient Saf Surg Section Body Doc Link PMC2584001 Disease Relevance 1.10 Pain Relevance 0.17
Campos et al. hypothesize that the formation of HO in neurogenic injuries may be related to proprioception dysfunction.
HO Binding (formation) of associated with injury and heterotopic ossification
13) Confidence 0.02 Published 2008 Journal Patient Saf Surg Section Body Doc Link PMC2584001 Disease Relevance 2.17 Pain Relevance 0.19

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