INT116538

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Context Info
Confidence 0.48
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.84
Pain Relevance 3.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GRK6)
Anatomy Link Frequency
brains 3
GRK6 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 18 100.00 Very High Very High Very High
addiction 6 99.06 Very High Very High Very High
opiate 33 98.86 Very High Very High Very High
methadone 6 97.72 Very High Very High Very High
tolerance 6 90.88 High High
Disease Link Frequency Relevance Heat
Opiate Addiction 6 99.06 Very High Very High Very High
Overdose 6 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreased immunodensities of micro-opioid receptors, receptor kinases GRK 2/6 and beta-arrestin-2 in postmortem brains of opiate addicts.
Negative_regulation (Decreased) of GRK 2/6 in brains associated with opiate and opioid receptor
1) Confidence 0.48 Published 2004 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 14969742 Disease Relevance 0.21 Pain Relevance 0.93
The results indicate that opiate addiction in humans (tolerant state) is associated with down-regulation of brain micro-opioid receptors and regulatory GRK 2/6 and beta-arrestin-2 proteins.
Negative_regulation (down-regulation) of GRK 2/6 in brain associated with addiction, opioid receptor and opiate
2) Confidence 0.35 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14969742 Disease Relevance 0.30 Pain Relevance 1.18
In the same brains, significant decreases in the immunodensities of GRK 2 (19%, n=24, P<0.05), GRK 6 (25%, n=24, P<0.002) and beta-arrestin-2 (22%, n=24, P< 0.0005) were also quantitated.
Negative_regulation (decreases) of GRK 6 in brains
3) Confidence 0.35 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14969742 Disease Relevance 0.34 Pain Relevance 1.20

General Comments

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