INT116540

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Context Info
Confidence 0.48
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 35
Total Number 37
Disease Relevance 16.32
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Twist1) nucleus (Twist1) DNA binding (Twist1)
transcription factor binding (Twist1)
Anatomy Link Frequency
macrophages 2
proximal 2
bar 1
retina 1
muscle 1
Twist1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 252 98.32 Very High Very High Very High
cryotherapy 10 96.48 Very High Very High Very High
palliative 14 94.72 High High
agonist 38 90.72 High High
cva 46 88.24 High High
gABA 29 87.76 High High
Inflammation 443 85.04 High High
Glutamate 17 84.32 Quite High
Inflammatory response 19 82.52 Quite High
dexamethasone 4 78.48 Quite High
Disease Link Frequency Relevance Heat
Cancer 1135 100.00 Very High Very High Very High
Skin Cancer 168 100.00 Very High Very High Very High
Photosensitivity Disorders 15 100.00 Very High Very High Very High
Epilepsy 10 100.00 Very High Very High Very High
Age-related Macular Degeneration 288 99.84 Very High Very High Very High
Apoptosis 119 99.40 Very High Very High Very High
Breast Cancer 1 98.48 Very High Very High Very High
Malignant Neoplastic Disease 22 97.96 Very High Very High Very High
Metastasis 38 97.36 Very High Very High Very High
Tonic-clonic Epilepsy 1 94.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B–driven transcription of a reporter gene construct that lacks E-boxes in the promoter, suggesting that twist1 acts through binding to E-boxes, as in macrophages.
twist1 Binding (binding) of in macrophages
1) Confidence 0.48 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.06 Pain Relevance 0.09
For COS cells, it has been shown that ectopically expressed twist1 can interact directly with the p65 subunit of NF-?
twist1 Binding (interact) of
2) Confidence 0.48 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.07 Pain Relevance 0.04
The following primers were used to amplify the proximal twist1 promoter: (?
twist1 Binding (amplify) of in proximal
3) Confidence 0.37 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.31 Pain Relevance 0.07
B have to bind to the promoter of twist1 in Th cells to induce expression, i.e., twist1 is expressed only by activated Th cells.
twist1 Binding (bind) of
4) Confidence 0.37 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.22 Pain Relevance 0.11
Twist1 itself is a transcriptional repressor binding to E-boxes in the regulatory regions of target genes (34).
Twist1 Binding (binding) of
5) Confidence 0.37 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.08 Pain Relevance 0.04
B cannot induce transcription of twist1 on their own, but require concerted binding of activated STAT4 to the promoter of twist1.
twist1 Binding (binding) of
6) Confidence 0.37 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.19 Pain Relevance 0.09
The proximal promoter of twist1 contains phylogenetically conserved binding sites for NFAT, NF-?
twist1 Binding (binding) of in proximal
7) Confidence 0.37 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.23 Pain Relevance 0.12
In contrast, for primary murine macrophages, twist1 has been shown to block transcription of target genes by binding to E-boxes within the promoter (5).
twist1 Binding (binding) of in macrophages
8) Confidence 0.35 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.07 Pain Relevance 0.03
This result implies that twist1 regulates gene expression of Th1 cells by binding to E-boxes of specific target genes, and not the entirety of NF-?
twist1 Binding (binding) of in Th1 cells
9) Confidence 0.35 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.21 Pain Relevance 0.25
Identification of domain/criteria for PDT
PDT Binding (criteria) of
10) Confidence 0.32 Published 2010 Journal Health Res Policy Syst Section Body Doc Link PMC2846928 Disease Relevance 0 Pain Relevance 0
Photosensitizing drugs for topical PDT
PDT Binding (drugs) of
11) Confidence 0.32 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503644 Disease Relevance 0.54 Pain Relevance 0
Today, most commonly, the photosensitization for PDT of superficial skin lesions is obtained by topical application of ?
PDT Binding (photosensitization) of in skin associated with photosensitivity disorders
12) Confidence 0.32 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503644 Disease Relevance 0.70 Pain Relevance 0
Several studies have been performed investigating PDT for superficial BCCs.
PDT Binding (investigating) of
13) Confidence 0.32 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503644 Disease Relevance 0.27 Pain Relevance 0.09
IVB alone had similar efficacy and safety to IVB plus PDT for treatment of patients, including those who were treatment-naïve.13
PDT Binding (efficacy) of
14) Confidence 0.26 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2964964 Disease Relevance 0.06 Pain Relevance 0
It was possible that the reason why 3 out of 10 contralateral tumors escaped from PDT mediated immune recognition and elimination could be due to the loss of the expression of the ?
PDT Binding (recognition) of associated with cancer
15) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001867 Disease Relevance 0.98 Pain Relevance 0
The CTLs from PDT treated mice bearing antigen positive CT26.CL25 tumors were capable of causing specific lysis of antigen positive target cells and bind the immunodominant peptide epitope derived from ?
PDT Binding (bind) of associated with cancer
16) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001867 Disease Relevance 1.18 Pain Relevance 0.05
PDT has been shown to effectively engage both innate and adaptive immune systems in the host's responses to cancer [24], [25], [26].
PDT Binding (engage) of in immune systems associated with cancer
17) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001867 Disease Relevance 1.38 Pain Relevance 0.14
We limited PDT to one session in our treatment protocol for two purposes: 1- To reduce the potential side effects of PDT on the physiological choroidal vasculature, RPE and neurosensory retina; 2- To reduce the cost of treatment.
PDT Binding (limited) of in retina
18) Confidence 0.25 Published 2007 Journal BMC Ophthalmol Section Body Doc Link PMC1904176 Disease Relevance 0.17 Pain Relevance 0.04
Aggio et al treated two cases of neovascular AMD with a combination of PDT and intravitreal bevacizumab.
PDT Binding (combination) of associated with age-related macular degeneration
19) Confidence 0.24 Published 2007 Journal BMC Ophthalmol Section Body Doc Link PMC1904176 Disease Relevance 0.76 Pain Relevance 0
Studies that compared PDT with

standard tracheostomy [26, 27, 28, 29] demonstrated that PDT was quicker, less traumatic, associated with fewer early and late complications, and more cost-effective.

PDT Binding (associated) of
20) Confidence 0.23 Published 2000 Journal Crit Care Section Body Doc Link PMC29040 Disease Relevance 0.53 Pain Relevance 0.03

General Comments

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