INT116552

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Context Info
Confidence 0.61
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 12.70
Pain Relevance 7.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1)
cytoplasm (Nfkb1) cytosol (Nfkb1) signal transduction (Nfkb1)
Anatomy Link Frequency
HT-29 4
nucleus 4
heart 4
ganglion cell layer 3
hepatocytes 2
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 28 99.98 Very High Very High Very High
cINOD 15 99.98 Very High Very High Very High
Endep 22 99.80 Very High Very High Very High
Spinal cord 4 99.68 Very High Very High Very High
isoflurane 13 99.38 Very High Very High Very High
intrathecal 8 98.76 Very High Very High Very High
cytokine 35 98.52 Very High Very High Very High
Herpes zoster virus 2 97.16 Very High Very High Very High
chemokine 6 95.28 Very High Very High Very High
Inflammation 104 93.84 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 42 100.00 Very High Very High Very High
Apoptosis 16 100.00 Very High Very High Very High
Disease 38 99.98 Very High Very High Very High
Stress 60 98.94 Very High Very High Very High
Herpes Zoster 2 97.04 Very High Very High Very High
Cytomegalovirus Infection 4 96.74 Very High Very High Very High
Cancer 14 96.04 Very High Very High Very High
Necrosis 7 95.80 Very High Very High Very High
Chlamydia Infection 4 95.74 Very High Very High Very High
Infection 5 95.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As hypothesized, S1627 prevented the zymosan-induced nuclear translocation of NF-kappaB in the spinal cord and the upregulation of NF-kappaB-responsive genes including cyclooxygenase-2, tumor necrosis factor-alpha, and IL-1beta.
Positive_regulation (induced) of Localization (translocation) of NF-kappaB in spinal cord associated with necrosis, cancer and spinal cord
1) Confidence 0.61 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14973242 Disease Relevance 1.49 Pain Relevance 0.85
Moreover, amitriptyline/morphine co-infusion increased IkappaBalpha phosphorylation and the translocation of NF-kappaB p65 from the cytosol to the nucleus.
Positive_regulation (increased) of Localization (translocation) of NF-kappaB in nucleus associated with endep and morphine
2) Confidence 0.51 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.86
Moreover, addition of PD98059, a MAPK kinase inhibitor, significantly suppressed the LPS-induced NF-kappaB nuclear translocation and GM-CSF production, suggesting that the PPF-attenuated GM-CSF production in hepatocytes may be attributed to its suppressive effect on MAPK/ERK signaling pathway.
Positive_regulation (induced) of Localization (translocation) of NF-kappaB in hepatocytes
3) Confidence 0.46 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.27 Pain Relevance 0.12
Daily intrathecal injection of Ro106-9920 prevented the amitriptyline/morphine-induced NF-kappaB p65 translocation and reversed the amitriptyline/morphine-induced GLAST and GLT-1 upregulation and inhibited the restoration of EAAC1 expression.
Positive_regulation (induced) of Localization (translocation) of NF-kappaB associated with endep, morphine and intrathecal
4) Confidence 0.42 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.74
All three salicylates inhibited the diabetes-induced translocation of p50 (a subunit of NF-kappaB) into nuclei of retinal vascular endothelial cells of the isolated retinal vasculature, as well as of p50 and p65 into nuclei of cells in the ganglion cell layer and inner nuclear layer on whole-retinal sections.
Positive_regulation (diabetes-induced) of Localization (translocation) of NF-kappaB in ganglion cell layer associated with ganglion cysts and diabetes mellitus
5) Confidence 0.40 Published 2007 Journal Diabetes Section Abstract Doc Link 17259377 Disease Relevance 1.37 Pain Relevance 0.24
Isoflurane exposure also evoked a robust increase in myocardial NO content, followed by nucleus-bound translocation of p65 or p50 subunit of NF-kappaB and increase in NF-kappaB DNA-binding activity in heart tissues.
Positive_regulation (increase) of Localization (translocation) of NF-kappaB in heart associated with isoflurane
6) Confidence 0.35 Published 2008 Journal Shock Section Abstract Doc Link 18708911 Disease Relevance 0.16 Pain Relevance 0.36
Isoflurane exposure also evoked a robust increase in myocardial NO content, followed by nucleus-bound translocation of p65 or p50 subunit of NF-kappaB and increase in NF-kappaB DNA-binding activity in heart tissues.
Positive_regulation (increase) of Localization (translocation) of NF-kappaB in heart associated with isoflurane
7) Confidence 0.35 Published 2008 Journal Shock Section Abstract Doc Link 18708911 Disease Relevance 0.22 Pain Relevance 0.37
In terms of effect size, the odds ratios do not differ substantively from single SNP results although in logistic regression models adjusted for covariates, IKBKB rs3747811 and IL6 rs1800797 may mitigate increased risk of NFKB1.
Positive_regulation (increased) of Localization (risk) of NFKB1
8) Confidence 0.33 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC3006374 Disease Relevance 0.27 Pain Relevance 0.03
B is phosphorylated and degraded, allowing NF-kappaB to translocate to the nucleus where it binds DNA and triggers the transcription of target genes, such as proinflammatory cytokines, chemokines, and cell adhesion molecules.
Positive_regulation (allowing) of Localization (translocate) of NF-kappaB in nucleus associated with chemokine, adhesions and cytokine
9) Confidence 0.27 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.76 Pain Relevance 0.48
Furthermore, we show that all of these NSAIDs induce nucleolar translocation of the RelA subunit of NF-kappaB.
Positive_regulation (induce) of Localization (translocation) of NF-kappaB associated with cinod
10) Confidence 0.15 Published 2008 Journal Oncogene Section Abstract Doc Link 18059344 Disease Relevance 0.45 Pain Relevance 0.56
All three salicylates inhibited the diabetes-induced translocation of p50 (a subunit of NF-kappaB) into nuclei of retinal vascular endothelial cells of the isolated retinal vasculature, as well as of p50 and p65 into nuclei of cells in the ganglion cell layer and inner nuclear layer on whole-retinal sections.
Positive_regulation (diabetes-induced) of in inner nuclear layer Localization (translocation) of NF-kappaB in ganglion cell layer associated with ganglion cysts and diabetes mellitus
11) Confidence 0.14 Published 2007 Journal Diabetes Section Abstract Doc Link 17259377 Disease Relevance 1.37 Pain Relevance 0.24
Stimulation of HT-29 cells with G-Gly led to a rapid increase in ERK and p38 MAP kinase phosphorylation and increased nuclear translocation of active NF-kappaB.
Positive_regulation (increased) of Localization (translocation) of NF-kappaB in HT-29
12) Confidence 0.05 Published 2006 Journal Regul. Pept. Section Abstract Doc Link 16169610 Disease Relevance 0.94 Pain Relevance 0.07
Stimulation of HT-29 cells with G-Gly led to a rapid increase in ERK and p38 MAP kinase phosphorylation and increased nuclear translocation of active NF-kappaB.
Positive_regulation (increase) of Localization (translocation) of NF-kappaB in HT-29
13) Confidence 0.03 Published 2006 Journal Regul. Pept. Section Abstract Doc Link 16169610 Disease Relevance 0.96 Pain Relevance 0.07
The classical cardiovascular risk factors (hypercholesterolemia, hypertension, smoking, diabetes, sedentary, etc.) and the so called new risk factors like hiperhomocysteinemia, lipoprotein Lp(a), infections by Chlamydia pneumoniae, Helicobacter Pilorae, Cytomegalovirus, herpes zoster virus or bacteroides gingivalis, all have a common factor which is a state of oxidative stress that directly or through heating proteins (HSP-60), stimulate NF-kB replication that leads to the production of proatherogenic cytokines like TNF-?
Positive_regulation (leads) of Localization (replication) of NF-kB associated with stress, pressure and volume under development, nicotine addiction, diabetes mellitus, cytomegalovirus infection, chlamydia infection, infection, cytokine, herpes zoster virus and hyperlipidemia
14) Confidence 0.03 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1434727 Disease Relevance 1.48 Pain Relevance 0.33
The classical cardiovascular risk factors (hypercholesterolemia, hypertension, smoking, diabetes, sedentary, etc.) and the so called new risk factors like hiperhomocysteinemia, lipoprotein Lp(a), infections by Chlamydia pneumoniae, Helicobacter Pilorae, Cytomegalovirus, herpes zoster virus or bacteroides gingivalis, all have a common factor which is a state of oxidative stress that directly or through heating proteins (HSP-60), stimulate NF-kB replication that leads to the production of proatherogenic cytokines like TNF-?
Positive_regulation (stimulate) of Localization (replication) of NF-kB associated with stress, pressure and volume under development, nicotine addiction, diabetes mellitus, cytomegalovirus infection, chlamydia infection, infection, cytokine, herpes zoster virus and hyperlipidemia
15) Confidence 0.03 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1434727 Disease Relevance 1.43 Pain Relevance 0.33
Proteins that are mutated in AIDs mediate the regulation of NFkappaB activation, cell apoptosis, and IL-1beta secretion through cross-regulated and sometimes common signaling pathways.
Positive_regulation (mediate) of Localization (secretion) of NFkappaB associated with apoptosis and disease
16) Confidence 0.01 Published 2008 Journal Best Pract Res Clin Rheumatol Section Abstract Doc Link 19028365 Disease Relevance 1.54 Pain Relevance 0.10

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