INT116553

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.35
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ikbkb) kinase activity (Ikbkb) cytoplasm (Ikbkb)
Ikbkb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 11 93.76 High High
Inflammation 31 79.84 Quite High
Hyperalgesia 3 76.80 Quite High
Eae 2 75.00 Quite High
neuralgia 3 25.00 Low Low
Pain 3 25.00 Low Low
COX2 2 25.00 Low Low
Analgesic 2 25.00 Low Low
Spinal cord 1 25.00 Low Low
Neuropathic pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 2 95.28 Very High Very High Very High
Injury 2 85.44 High High
Infection 2 84.72 Quite High
INFLAMMATION 28 79.84 Quite High
Glioma 2 78.68 Quite High
Hyperalgesia 3 76.80 Quite High
Neuropathic Pain 3 75.00 Quite High
Autoimmune Disease 12 66.00 Quite High
Targeted Disruption 3 58.64 Quite High
Opportunistic Infections 1 50.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IKK2 phosphorylates the Ser32 and Ser36 residues of I?
Phosphorylation (phosphorylates) of IKK2
1) Confidence 0.37 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721774 Disease Relevance 0.57 Pain Relevance 0.23
Because LPS is known to stimulate inhibitor kappaB (IkappaB) kinase (IKK)-mediated phosphorylation of IkappaB followed by its degradation, which in turn induces nuclear factor (NF)-kappaB nuclear translocation leading to transcriptional activation of COX-2 gene, the effect of gamma-mangostin on the IKK/IkappaB cascade controlling the NF-kappaB activation was examined.
Phosphorylation (phosphorylation) of inhibitor kappaB
2) Confidence 0.15 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15322259 Disease Relevance 0.15 Pain Relevance 0
Phosphorylation of IkappaB through IkappaB kinase (IKK) is the first step in nuclear factor kappaB (NF-kappaB) activation and upregulation of NF-kappaB-responsive genes.
Phosphorylation (Phosphorylation) of IkappaB kinase
3) Confidence 0.15 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14973242 Disease Relevance 0.63 Pain Relevance 0.26

General Comments

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