INT116557

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Context Info
Confidence 0.02
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.51
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1)
cytoplasm (Nfkb1) signal transducer activity (Olr1627) cytosol (Nfkb1)
Anatomy Link Frequency
spinal cord 2
Olr1627 (Rattus norvegicus)
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 1 99.68 Very High Very High Very High
Inflammation 8 94.96 High High
Neuropathic pain 1 92.20 High High
Eae 2 91.16 High High
allodynia 1 89.76 High High
Hyperalgesia 3 82.72 Quite High
Pain 1 80.40 Quite High
neuralgia 3 25.00 Low Low
Analgesic 2 25.00 Low Low
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 1 96.04 Very High Very High Very High
Necrosis 1 95.80 Very High Very High Very High
Nociception 1 95.44 Very High Very High Very High
INFLAMMATION 6 94.96 High High
Neuropathic Pain 3 92.20 High High
Injury 2 91.16 High High
Pressure And Volume Under Development 1 86.72 High High
Hyperalgesia 3 82.72 Quite High
Stress 1 55.96 Quite High
Infection 1 55.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As hypothesized, S1627 prevented the zymosan-induced nuclear translocation of NF-kappaB in the spinal cord and the upregulation of NF-kappaB-responsive genes including cyclooxygenase-2, tumor necrosis factor-alpha, and IL-1beta.
S1627 Negative_regulation (prevented) of Localization (translocation) of NF-kappaB in spinal cord associated with necrosis, cancer and spinal cord
1) Confidence 0.02 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14973242 Disease Relevance 1.51 Pain Relevance 0.85

General Comments

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