INT116561

Context Info Confidence 0.04 First Reported 2004 Last Reported 2004 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.66 Pain Relevance 0.27

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1) nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)

Ptpn5 (Rattus norvegicus) Nfkb1 (Mus musculus)

Pain Link Frequency Relevance Heat Hyperalgesia 3 82.56 Inflammation 8 81.20 Eae 2 75.00 neuralgia 3 25.00 Analgesic 2 25.00 COX2 1 25.00 Spinal cord 1 25.00 Neuropathic pain 1 25.00 Pain 1 25.00 allodynia 1 25.00

Disease Link Frequency Relevance Heat Injury 2 91.20 Infection 1 90.48 Stress 1 89.28 Hyperalgesia 3 82.56 INFLAMMATION 6 81.20 Neuropathic Pain 3 75.00 Pressure And Volume Under Development 1 27.68 Necrosis 1 25.00 Nociception 1 25.00 Cancer 1 25.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Phosphorylation of IkappaB through IkappaB kinase (IKK) is the first step in nuclear factor kappaB (NF-kappaB) activation and upregulation of NF-kappaB-responsive genes.

step Positive_regulation (activation) of nuclear factor kappaB

1) Confidence 0.04 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14973242 Disease Relevance 0.66 Pain Relevance 0.27

General Comments

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