INT11659

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Context Info
Confidence 0.78
First Reported 1989
Last Reported 2011
Negated 4
Speculated 1
Reported most in Body
Documents 164
Total Number 166
Disease Relevance 78.49
Pain Relevance 22.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL2A1) extracellular region (COL2A1) cytoplasm (COL2A1)
Anatomy Link Frequency
chondrocytes 29
cartilage 14
cleavage 9
knees 4
articular cartilage 3
COL2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1177 99.88 Very High Very High Very High
aspirin 5 99.84 Very High Very High Very High
algogenic 4 99.66 Very High Very High Very High
antagonist 38 99.62 Very High Very High Very High
Osteoarthritis 2406 99.60 Very High Very High Very High
metalloproteinase 486 99.56 Very High Very High Very High
Snapping jaw 34 99.44 Very High Very High Very High
Inflammation 707 99.22 Very High Very High Very High
cytokine 383 98.92 Very High Very High Very High
Arthritis 302 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Otitis Media 985 100.00 Very High Very High Very High
Hypertrophy 418 100.00 Very High Very High Very High
Infection 288 100.00 Very High Very High Very High
Necrosis 112 100.00 Very High Very High Very High
Rheumatoid Arthritis 1205 99.88 Very High Very High Very High
Fever 41 99.80 Very High Very High Very High
Focal Cartilage Defect 6 99.76 Very High Very High Very High
Otitis Media With Effusion 79 99.72 Very High Very High Very High
Knee Osteoarthritis 165 99.60 Very High Very High Very High
Osteoarthritis 2468 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then assessed the effect of the AAA hydrogel on NHC (Normal Human Chondrocyte) cell viability and on the production of important extracellular matrix factors, such as glycosaminoglycans and Type II collagen.
Gene_expression (production) of Type II collagen in extracellular matrix
1) Confidence 0.78 Published 2008 Journal Journal of biomedical materials research. Part A Section Abstract Doc Link 17618483 Disease Relevance 0.16 Pain Relevance 0.07
This would be likely to have its most profound effect on pathology during early embryogenesis when the eye is forming and COL2A1 is first expressed.
Gene_expression (expressed) of COL2A1 in eye
2) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.92 Pain Relevance 0
Genetic differences in COL2A1 type IIA expression, triggered directly by the parasite and/or the tissue response to the parasite, could play a role in the continuing postnatal development of pathology associated with congenitally-acquired toxoplasmosis.
Gene_expression (expression) of COL2A1 associated with toxoplasmosis
3) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.95 Pain Relevance 0.11
The benefit of finding a genetic association with specific genes is that we can begin to understand more about how the parasite triggers the development of ocular disease during embryogenesis and fetal development by examining what is known about the chronological expression and localization of COL2A1 and ABCA4 during development and after birth.
Gene_expression (expression) of COL2A1 associated with eye disease
4) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 1.43 Pain Relevance 0.03
It did not upregulate chondrocyte proliferation and type II collagen synthesis as evidenced by the lack of significant changes in the expression of cyclin B2 and COL2A1, respectively.
Gene_expression (expression) of COL2A1 in chondrocyte
5) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.51 Pain Relevance 0.17
It did not upregulate chondrocyte proliferation and type II collagen synthesis as evidenced by the lack of significant changes in the expression of cyclin B2 and COL2A1, respectively.
Gene_expression (synthesis) of type II collagen in chondrocyte
6) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.47 Pain Relevance 0.15
It can inhibit collagen synthesis in growth plate chondrocytes [27], mediate MMP production in articular chondrocytes and cartilage [6,28], inhibit chondrocyte proliferation [29], promote IL-1?
Gene_expression (synthesis) of collagen in articular associated with metalloproteinase
7) Confidence 0.75 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.94 Pain Relevance 0.27
In addition, we also studied collagen type II expression, generally acknowledged to be the most important chondrogenic marker.
Gene_expression (expression) of collagen type II
8) Confidence 0.73 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.23 Pain Relevance 0.09
Interestingly, while the SOX9 dependency of COL2A1 expression has been unequivocally shown, it may not actually be a key regulator of COL2A1 promoter activity in human adult articular chondrocytes [82].
Gene_expression (expression) of COL2A1 in chondrocytes
9) Confidence 0.73 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911888 Disease Relevance 0.12 Pain Relevance 0
Even at an etodolac concentration of 80 micrograms/ml, DNA synthesis, proteoglycan synthesis, and type-II collagen synthesis were unchanged.
Gene_expression (synthesis) of type-II collagen
10) Confidence 0.73 Published 1989 Journal Clin. Rheumatol. Section Abstract Doc Link 2545406 Disease Relevance 0.16 Pain Relevance 0.12
Proteoglycan production was also markedly decreased by ASA, while synthesis of type II collagen was not modified.
Gene_expression (synthesis) of type II collagen associated with aspirin
11) Confidence 0.72 Published 1992 Journal Clin. Rheumatol. Section Abstract Doc Link 1582121 Disease Relevance 0.09 Pain Relevance 0.42
This involves phenotypic hypertrophy-related changes in chondrocytes, such as the production of type X collagen (COL10A1) (hypertrophy marker), and the upregulation of collagenase matrix metalloproteinase (MMP)-13, as is seen in the fetal growth plate [1-3].
Gene_expression (production) of collagen in growth plate associated with hypertrophy and metalloproteinase
12) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.90 Pain Relevance 0.59
The aim of the study was to present a ANFH of three young persons diagnosed too late that ended with implantation of total hip arthoplasty (THA).
Gene_expression (present) of ANFH in hip
13) Confidence 0.65 Published 2010 Journal Chir Narzadow Ruchu Ortop Pol Section Abstract Doc Link 20695186 Disease Relevance 0.55 Pain Relevance 0.07
The pathogens identified were: Brucella (5), coagulase-negative Staphylococcus aureus (4), Staphylococcus aureus (3), unidentified (4).
Neg (negative) Gene_expression (negative) of Staphylococcus aureus
14) Confidence 0.65 Published 2010 Journal Acta Orthop Belg Section Abstract Doc Link 20306973 Disease Relevance 0.83 Pain Relevance 0.17
The pathogens identified were: Brucella (5), coagulase-negative Staphylococcus aureus (4), Staphylococcus aureus (3), unidentified (4).
Neg (negative) Gene_expression (negative) of Staphylococcus aureus
15) Confidence 0.65 Published 2010 Journal Acta Orthop Belg Section Abstract Doc Link 20306973 Disease Relevance 0.83 Pain Relevance 0.16
Thirty-three patients (39 hips) with avascular necrosis of the femoral head (ANFH), who received vascularized iliac pedicle bone grafting at the Orthopaedic Department of Linkou Medical Center, Chang-Gung Memorial Hospital, were followed for more than 4 years (Group 1).
Gene_expression (necrosis) of ANFH in iliac associated with necrosis
16) Confidence 0.65 Published 2006 Journal J Reconstr Microsurg Section Abstract Doc Link 16425117 Disease Relevance 0.17 Pain Relevance 0
Avascular necrosis of the femoral head (ANFH) is one of the crippling complications of sickle cell disease (SCD), and to date there is no classification that could identify patients in the early phase of the necrosis.
Gene_expression (necrosis) of ANFH in ANFH associated with sickle cell anemia and necrosis
17) Confidence 0.65 Published 1993 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 8472450 Disease Relevance 0.58 Pain Relevance 0.05
0.033) and COL2A1 rs2070739 (P?
Gene_expression (0.033) of COL2A1
18) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2390765 Disease Relevance 0.28 Pain Relevance 0
Osteoarthritic changes in articular cartilage involve progressive proteolytic degradation of its extracellular matrix, composed mainly of type II collagen (COL2A1) and aggrecan, eventually leading to a loss of the cartilage.
Gene_expression (composed) of COL2A1 in extracellular matrix associated with osteoarthritis
19) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.81 Pain Relevance 0.49
Moreover, we observed an inverse relationship in control cultures (no added PGE2) between PGE2 content and COL2A1 cleavage.
Gene_expression (cleavage) of COL2A1 in cleavage
20) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.54 Pain Relevance 0.31

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