INT1166

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 56
Total Number 56
Disease Relevance 12.54
Pain Relevance 28.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Dbh) cytoplasm (Dbh)
Anatomy Link Frequency
neurons 4
brain 2
sympathetic 2
heart 2
hypothalamus 2
Dbh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 456 100.00 Very High Very High Very High
Catecholamine 29 100.00 Very High Very High Very High
Morphine 221 99.92 Very High Very High Very High
Nucleus accumbens 187 99.92 Very High Very High Very High
electroacupuncture 124 99.88 Very High Very High Very High
medulla 9 99.88 Very High Very High Very High
Acupuncture 412 99.84 Very High Very High Very High
Opioid 57 99.80 Very High Very High Very High
Dynorphin 28 99.76 Very High Very High Very High
Clonidine 67 99.74 Very High Very High Very High
Disease Link Frequency Relevance Heat
Decapitation 1 100.00 Very High Very High Very High
Disease 14 99.78 Very High Very High Very High
"congenital, Hereditary, And Neonatal Diseases And Abnormalities" 3 99.76 Very High Very High Very High
Hypertension 9 99.58 Very High Very High Very High
Quadriplegia 1 99.22 Very High Very High Very High
Pheochromocytoma 1 98.78 Very High Very High Very High
Syndrome 18 98.40 Very High Very High Very High
Adrenal Insufficiency 1 98.40 Very High Very High Very High
Stress 19 98.24 Very High Very High Very High
Pressure Volume 2 Under Development 24 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with a DBH inhibitor also prevented the development of a secondary (conditioned) reinforcer based on primary reinforcement assosiated with either drug.
Negative_regulation (inhibitor) of DBH
1) Confidence 0.59 Published 1975 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 168592 Disease Relevance 0 Pain Relevance 0.36
The role of brain noradrenergic neurons in mediating the reinforcing properties of small intravenous doses of morphine and d-amphetamine was investigated by pretreatment of rats with the norepinephrine-depleting agents diethyldithiocarbamate and U-14,624, inhibitors of dopamine-beta-hydroxylase (DBH).
Negative_regulation (inhibitors) of DBH in neurons associated with dopamine and morphine
2) Confidence 0.59 Published 1975 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 168592 Disease Relevance 0 Pain Relevance 0.31
The role of brain noradrenergic neurons in mediating the reinforcing properties of small intravenous doses of morphine and d-amphetamine was investigated by pretreatment of rats with the norepinephrine-depleting agents diethyldithiocarbamate and U-14,624, inhibitors of dopamine-beta-hydroxylase (DBH).
Negative_regulation (inhibitors) of dopamine-beta-hydroxylase in neurons associated with dopamine and morphine
3) Confidence 0.59 Published 1975 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 168592 Disease Relevance 0 Pain Relevance 0.31
The decreased DBH activity in these nuclei may be related to stimulation of respective alpha-noradrenergic receptors.
Negative_regulation (decreased) of DBH
4) Confidence 0.58 Published 1980 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7401402 Disease Relevance 0.24 Pain Relevance 0.56
The effects are likely to be due to the presence of fusaric acid in FO, which inhibits dopamine beta-hydroxylase and is known to have dopaminergic effects.
Negative_regulation (inhibits) of dopamine beta-hydroxylase associated with dopamine
5) Confidence 0.58 Published 1996 Journal Indian J. Exp. Biol. Section Abstract Doc Link 9063074 Disease Relevance 0.62 Pain Relevance 0.46
Dopamine accumulation after dopamine beta-hydroxylase inhibition in rat heart as an index of norepinephrine turnover.
Negative_regulation (inhibition) of dopamine beta-hydroxylase in heart associated with dopamine
6) Confidence 0.58 Published 1982 Journal Life Sci. Section Title Doc Link 6290819 Disease Relevance 0 Pain Relevance 0.57
L-DOPS is very effective in treatment of deficiency of dopamine-beta-hydroxylase (DBH), the enzyme required for conversion of dopamine to NE in sympathetic nerves.
Negative_regulation (deficiency) of DBH in sympathetic associated with dopamine
7) Confidence 0.58 Published 2006 Journal Cardiovasc Drug Rev Section Abstract Doc Link 17214596 Disease Relevance 0.25 Pain Relevance 0.12
L-DOPS holds promise for treating other much more common conditions involving decreased DBH activity or NE deficiency, such as a variety of syndromes associated with neurogenic orthostatic hypotension.
Negative_regulation (decreased) of DBH associated with pressure volume 2 under development and syndrome
8) Confidence 0.58 Published 2006 Journal Cardiovasc Drug Rev Section Abstract Doc Link 17214596 Disease Relevance 0.42 Pain Relevance 0.09
L-DOPS is very effective in treatment of deficiency of dopamine-beta-hydroxylase (DBH), the enzyme required for conversion of dopamine to NE in sympathetic nerves.
Negative_regulation (deficiency) of dopamine-beta-hydroxylase in sympathetic associated with dopamine
9) Confidence 0.58 Published 2006 Journal Cardiovasc Drug Rev Section Abstract Doc Link 17214596 Disease Relevance 0.25 Pain Relevance 0.12
This was accompanied by a decrease in the dopamine-beta-hydroxylase and phenylethanolamine-N-methyl transferase activities of the A1/C1 region.
Negative_regulation (decrease) of dopamine-beta-hydroxylase associated with dopamine
10) Confidence 0.57 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2869960 Disease Relevance 0.30 Pain Relevance 0.83
Reduction and/or loss of unmyelinated and small myelinated fibers is found, as reduction of dopamine beta-hydroxylase in blood.
Negative_regulation (reduction) of dopamine beta-hydroxylase in blood associated with dopamine and unmyelinated
11) Confidence 0.57 Published 1994 Journal Arq Neuropsiquiatr Section Abstract Doc Link 8002797 Disease Relevance 0.85 Pain Relevance 0.19
Disulfiram inhibits dopamine beta-hydroxylase resulting in an excess of dopamine and decreased synthesis of norepinephrine.
Negative_regulation (inhibits) of dopamine beta-hydroxylase
12) Confidence 0.57 Published 2000 Journal Addiction Section Body Doc Link 10723850 Disease Relevance 0.06 Pain Relevance 0
A tendency was also observed in the brain toward a decrease in the activity of DBH and COMT and an increase in the activity of cAMP and cGMP.
Negative_regulation (decrease) of DBH in brain
13) Confidence 0.56 Published 1994 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 7969881 Disease Relevance 0.28 Pain Relevance 0.22
However, recent immunocytochemical work in our laboratory correlated reductions in hypothalamic norepinephrine content and turnover rate with reductions in tyrosine hydroxylase and dopamine-beta-hydroxylase fiber density in the hypothalamus of morphine-exposed female rats.
Negative_regulation (reductions) of dopamine-beta-hydroxylase in hypothalamus associated with dopamine and morphine
14) Confidence 0.55 Published 1997 Journal Neuroscience Section Abstract Doc Link 9015318 Disease Relevance 0.22 Pain Relevance 0.62
Molecular genetic analysis studies suggested that DBH deficiency is a Mendelian recessive disorder attributable to heterogenous mutations at the DBH locus.
Negative_regulation (deficiency) of DBH
15) Confidence 0.51 Published 2002 Journal Clin. Auton. Res. Section Abstract Doc Link 12102462 Disease Relevance 0.87 Pain Relevance 0.21
Suppression of voluntary ingestion of morphine by inhibition of dopamine-beta-hydroxylase.
Negative_regulation (inhibition) of dopamine-beta-hydroxylase associated with dopamine and morphine
16) Confidence 0.49 Published 1978 Journal Arch Int Pharmacodyn Ther Section Title Doc Link 666451 Disease Relevance 0 Pain Relevance 0.61
Treatment with FLA-63, using a regimen that was shown to inhibit dopamine-beta-hydroxylase in brain, caused a diminution in the ability of alpha-MD to depress locomotor activity.
Negative_regulation (inhibit) of dopamine-beta-hydroxylase in brain associated with dopamine and eae
17) Confidence 0.44 Published 1980 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6250499 Disease Relevance 0.17 Pain Relevance 0.65
Since noradrenergic neurons in the brain appear to inhibit ACTH secretion and dopamine-beta-hydroxylase (DBH) is found in noradrenergic neurons, the effect of variations in pituitary-adrenal activity on the activity of DBH in the brain stem, hypothalamus and hippocampus was determined.
Negative_regulation (inhibit) of dopamine-beta-hydroxylase in neurons associated with dopamine and hippocampus
18) Confidence 0.43 Published 1976 Journal Neuroendocrinology Section Abstract Doc Link 967301 Disease Relevance 0.19 Pain Relevance 0.21
In conclusion, clonidine selectively lowers DBH activity in the LC, while alpha-methyldopa appears to decrease the enzyme activity in the medullary NTS and A1 cell areas, suggesting different sites of action of both drugs.
Negative_regulation (lowers) of DBH associated with locus ceruleus and clonidine
19) Confidence 0.43 Published 1980 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7401402 Disease Relevance 0.27 Pain Relevance 0.60
Repeated administrations of clonidine to spontaneously hypertensive rats (SHR) markedly lowered dopamine beta-hydroxylase (DBH) activity in the locus coeruleus (LC) and increased it in the spinal intermediolateral cell column (IML), while alpha-methyldopa tended to lower the enzyme activity in the medullary nucleus tractus solitarii (NTS) and A1 cell areas.
Negative_regulation (lowered) of DBH in locus coeruleus associated with dopamine, locus ceruleus, hypertension, urological neuroanatomy and clonidine
20) Confidence 0.43 Published 1980 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 7401402 Disease Relevance 0.37 Pain Relevance 0.54

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