INT116619

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 25
Total Number 27
Disease Relevance 8.32
Pain Relevance 7.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Creb1) nucleus (Creb1) DNA binding (Creb1)
transcription factor binding (Creb1)
Anatomy Link Frequency
frontal cortex 4
cortex 3
spinal cord 2
brain 2
hippocampus 2
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 63 100.00 Very High Very High Very High
Kinase C 1 100.00 Very High Very High Very High
sSRI 99 99.96 Very High Very High Very High
bDMF 53 99.84 Very High Very High Very High
Spinal cord 3 99.68 Very High Very High Very High
Cholecystokinin 96 99.28 Very High Very High Very High
Endogenous opioid 1 99.08 Very High Very High Very High
Serotonin 50 99.02 Very High Very High Very High
antidepressant 532 98.88 Very High Very High Very High
Eae 63 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 76 100.00 Very High Very High Very High
Insulin Resistance 21 100.00 Very High Very High Very High
Stress 332 99.98 Very High Very High Very High
Depression 337 99.96 Very High Very High Very High
Targeted Disruption 181 99.20 Very High Very High Very High
Hemorrhagic Shock 1 98.20 Very High Very High Very High
Lung Injury 2 96.86 Very High Very High Very High
Pancreatitis 1 96.64 Very High Very High Very High
Psychosis 3 94.48 High High
Frailty 3 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, as reviewed by Tardito et al.[15] particularly the specific pro-noradrenergic antidepressants such as desimipramine and reboxetine have been shown to inhibit CREB activity[43], whereas selective serotonin reuptake inhibitors (SSRI) induce an activation of CREB.
Positive_regulation (induce) of Positive_regulation (activation) of CREB associated with antidepressant and ssri
1) Confidence 0.69 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.34 Pain Relevance 0.59
Peripheral noxious stimulation leads to phosphorylation and thereby activation of the transcription factor CREB in the spinal cord.
Positive_regulation (leads) of Positive_regulation (activation) of CREB in spinal cord associated with spinal cord
2) Confidence 0.68 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17692820 Disease Relevance 0.44 Pain Relevance 0.23
However, it has been shown that phosphorylation is a necessary prerequisite for CREB-mediated transcription but not fully sufficient[16].
Positive_regulation (necessary) of Positive_regulation (prerequisite) of CREB
3) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.14 Pain Relevance 0.16
Effect of imipramine treatment on the stress-induced increase in CREB-phosphorylation
Positive_regulation (induced) of Positive_regulation (increase) of CREB associated with stress
4) Confidence 0.50 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.65 Pain Relevance 0.08
These results suggest that the endogenous opioid tone acting on mu-/delta-receptors tonically stimulate CREB activation in the brain.
Positive_regulation (stimulate) of Positive_regulation (activation) of CREB in brain associated with endogenous opioid
5) Confidence 0.47 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975676 Disease Relevance 0.07 Pain Relevance 0.87
However, it was unknown whether the selective inhibition of serotonin reuptake is sufficient for inhibition of stress-induced CREB activation, as it is for the clinical antidepressant effect.
Spec (whether) Positive_regulation (induced) of Spec (whether) Positive_regulation (activation) of CREB associated with stress, antidepressant and serotonin
6) Confidence 0.47 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20122921 Disease Relevance 0.58 Pain Relevance 0.70
As CBP is a crucial cofactor in mediating phosphorylation-dependent CREB activity, enhanced levels of CBP might reflect increased CREB phosphorylation.
Positive_regulation (mediating) of Positive_regulation (dependent) of CREB
7) Confidence 0.46 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1855984 Disease Relevance 0.69 Pain Relevance 0.15
Pretreatment with DRz164 significant attenuated the morphine-induced activation of ERK and CREB in the frontal cortex, hippocampus, and striatum.
Positive_regulation (induced) of Positive_regulation (activation) of CREB in frontal cortex
8) Confidence 0.39 Published 2008 Journal Am J Drug Alcohol Abuse Section Body Doc Link 18850497 Disease Relevance 0 Pain Relevance 0
Although the mechanism of JNK-mediated CREB phosphorylation should be elucidated, JNK at least partly mediates ROS-induced hepatic insulin resistance through the activation of CREB.
Positive_regulation (induced) of Positive_regulation (activation) of CREB associated with insulin resistance
9) Confidence 0.38 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.18 Pain Relevance 0
Rolipram was effective in increasing significantly the levels of activated CREB and of BDNF the striatal spiny neurons, which might account for the beneficial effects observed in this model.
Positive_regulation (increasing) of Positive_regulation (activated) of CREB in neurons
10) Confidence 0.37 Published 2008 Journal Neurobiol. Dis. Section Abstract Doc Link 18424161 Disease Relevance 0.32 Pain Relevance 0.09
Here, we tested the putative role of GRP as an intra-SCN light signal at the behavioral and cellular levels, and we also tested whether GRP actions are dependent on activation of the cAMP response element-binding protein (CREB) pathway and Per1.
Spec (whether) Positive_regulation (dependent) of Spec (whether) Positive_regulation (activation) of CREB in SCN
11) Confidence 0.34 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17978049 Disease Relevance 0 Pain Relevance 0.08
This study suggests an important role for CREB activation in the behavioral responses to emotional stimuli.
Positive_regulation (role) of Positive_regulation (activation) of CREB
12) Confidence 0.32 Published 2005 Journal Mol Pain Section Body Doc Link PMC1079936 Disease Relevance 0.47 Pain Relevance 0.32
We tested therefore whether spadin was able to induce an increase in hippocampal neurogenesis and a faster activation of CREB.
Positive_regulation (increase) of Positive_regulation (activation) of CREB associated with neurodegenerative disease
13) Confidence 0.31 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.69 Pain Relevance 0.29
The next step was to determine whether the enhanced adult spadin-induced neurogenesis was related to an increased hippocampal activation of CREB, as measured by its phosphorylation into pCREB.
Positive_regulation (increased) of Positive_regulation (activation) of CREB associated with neurodegenerative disease
14) Confidence 0.31 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.28 Pain Relevance 0.18
Two major pathways responsible for CREB activation are the cAMP signaling pathway and the CaMKIV pathway [22,23] [for review, see [24]].
Positive_regulation (responsible) of Positive_regulation (activation) of CREB
15) Confidence 0.29 Published 2010 Journal Mol Brain Section Body Doc Link PMC2888801 Disease Relevance 0 Pain Relevance 0.03
Visual manipulation (MD) induces activation of CREB (Pham et al. 1999); a direct requirement for CREB in ocular dominance plasticity was shown in ferret using viral-mediated expression of a dominant-negative form of CREB (Mower et al. 2002).
Positive_regulation (induces) of Positive_regulation (activation) of CREB
16) Confidence 0.29 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0.06 Pain Relevance 0.08
5M) induced a large increase of pCREB labeling, restricted to the specific SGZ region of mouse hippocampal tissue sections (Figure 7D).
Positive_regulation (induced) of Positive_regulation (increase) of pCREB
17) Confidence 0.27 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2854129 Disease Relevance 0.16 Pain Relevance 0.14
A related finding of particular interest is the finding that activation of CREB is mediated by visual stimulation in young but not adult rats (Putignano et al. 2007), demonstrating that different intracellular pathways contribute to cortical plasticity at different ages.
Positive_regulation (mediated) of Positive_regulation (activation) of CREB
18) Confidence 0.27 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2674480 Disease Relevance 0 Pain Relevance 0
Viral-mediated increases of CREB in nucleus accumbens (NAc) induced depressive states in rodent FST [247, 309].
Positive_regulation (induced) of Positive_regulation (increases) of CREB in nucleus accumbens associated with nucleus accumbens, depression and eae
19) Confidence 0.22 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.28 Pain Relevance 0.64
The action of CCK on CART expression was shown to be mediated by activation of protein kinase C and cAMP response element binding protein (CREB) and was inhibited by orexigenic ghrelin [25].
Positive_regulation (mediated) of Positive_regulation (activation) of CREB associated with kinase c and cholecystokinin
20) Confidence 0.19 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2587474 Disease Relevance 0.15 Pain Relevance 0.69

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