INT116622

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Context Info
Confidence 0.39
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 11.98
Pain Relevance 3.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nefh)
Anatomy Link Frequency
cerebrospinal fluid 2
dendrites 1
dentate gyrus 1
perirhinal cortex 1
optic nerve 1
Nefh (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 37 99.56 Very High Very High Very High
Morphine 18 99.52 Very High Very High Very High
opioid receptor 2 98.16 Very High Very High Very High
Neuritis 17 97.56 Very High Very High Very High
Spinal cord 21 93.48 High High
Inflammation 3 91.36 High High
cerebral cortex 11 91.16 High High
Kappa opioid receptor 4 79.68 Quite High
dorsal root ganglion 38 78.96 Quite High
addiction 2 69.72 Quite High
Disease Link Frequency Relevance Heat
Disease 101 100.00 Very High Very High Very High
Leber Hereditary Optic Atrophy 336 99.64 Very High Very High Very High
Demyelinating Disease 35 99.56 Very High Very High Very High
Multiple Sclerosis 12 99.56 Very High Very High Very High
Injury 89 99.04 Very High Very High Very High
Pressure And Volume Under Development 42 97.64 Very High Very High Very High
Optic Neuritis 14 97.56 Very High Very High Very High
Increased Venous Pressure Under Development 8 96.72 Very High Very High Very High
Experimental Melanoma 2 95.92 Very High Very High Very High
Nerve Degeneration 7 95.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Axonal injury was a severe and acute event, insofar as serum pNF-H levels were not significantly elevated at early (EAE day 12) or late (EAE days 35 and 50) disease time points.
Neg (not) Positive_regulation (elevated) of pNF-H associated with multiple sclerosis, injury and disease
1) Confidence 0.39 Published 2008 Journal J. Neurosci. Res. Section Abstract Doc Link 18709652 Disease Relevance 1.98 Pain Relevance 0.29
Also, the marked increase in phosphorylated NF-H induced by chronic morphine in WT mice (two-fold) was abolished in mu -KO mice.
Positive_regulation (induced) of NF-H associated with morphine
2) Confidence 0.36 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975676 Disease Relevance 0.21 Pain Relevance 0.86
Also, the marked increase in phosphorylated NF-H induced by chronic morphine in WT mice (two-fold) was abolished in mu -KO mice.
Positive_regulation (increase) of NF-H associated with morphine
3) Confidence 0.36 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975676 Disease Relevance 0.22 Pain Relevance 0.86
These induced cells were found to be positive for neural markers such as Nestin, GFAP, NeuN, BT, Neurofilament (NF-70), and TH [Figures 9–11].


Positive_regulation (positive) of Neurofilament in neural
4) Confidence 0.20 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2847339 Disease Relevance 0.10 Pain Relevance 0
(25–35)-injected mice receiving vehicle compared to control mice, and administration of Kihi-to resulted in significant increases in P-NF-H expression levels in CA1 radiatum, dentate gyrus, parietal cortex, perirhinal cortex and the striatum (Figures 3 and 7).
Positive_regulation (increases) of P-NF-H in parietal cortex
5) Confidence 0.18 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.20 Pain Relevance 0.09
This was demonstrated by a reduction in levels of Vimentin and GAP-43, a marker for axonal regeneration, as well as NF-H, a late marker for axonal maturation in Ndel1 siRNA treated nerves (Fig. 6).
Positive_regulation (levels) of NF-H in nerves
6) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.09 Pain Relevance 0
During axon regeneration, the developmental pattern of IFs resumes: Vimentin is re-upregulated and expression of mature IFs such as NF-L and NF-H decreases [11]–[15], [17], [27], [32].
Positive_regulation (upregulated) of NF-H
7) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.32 Pain Relevance 0.07
In those patients, elevated pNF-H titers carried a poor visual prognosis as was also the case with our LHON patients, who had been followed clinically for 5 years and had exhibited no evidence for visual recovery.
Positive_regulation (elevated) of pNF-H associated with leber hereditary optic atrophy
8) Confidence 0.06 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605731 Disease Relevance 1.34 Pain Relevance 0.39
Whether asymptomatic carriers with elevated pNF-H titers will progress to full blown LHON is unclear.
Positive_regulation (elevated) of pNF-H associated with leber hereditary optic atrophy
9) Confidence 0.06 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605731 Disease Relevance 1.42 Pain Relevance 0.37
(25–35)-injected mice receiving vehicle compared to control mice, and administration of Kihi-to resulted in significant increases in P-NF-H expression levels in CA1 radiatum, dentate gyrus, parietal cortex, perirhinal cortex and the striatum (Figures 3 and 7).
Positive_regulation (increases) of P-NF-H in dentate gyrus
10) Confidence 0.06 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.20 Pain Relevance 0.09
(25–35)-injected mice receiving vehicle compared to control mice, and administration of Kihi-to resulted in significant increases in P-NF-H expression levels in CA1 radiatum, dentate gyrus, parietal cortex, perirhinal cortex and the striatum (Figures 3 and 7).
Positive_regulation (increases) of P-NF-H in perirhinal cortex
11) Confidence 0.06 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.20 Pain Relevance 0.09
In general, abnormal RT97 staining consisted mainly of abnormal pNFH accumulations both in the intraretinal aspect of RCG axons (shaped like rosary beads and small varicosities) and also within the cell bodies and primary dendrites of some RGCs (Figure 9D).
Positive_regulation (accumulations) of pNFH in dendrites associated with increased venous pressure under development
12) Confidence 0.06 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.53 Pain Relevance 0
These experimental findings together with the lack of pNF-H elevation in the single LHON patient examined during the first year of visual loss suggest that axonal loss in patients with acute LHON and disc edema has not yet occurred to any significant degree.
Positive_regulation (elevation) of pNF-H associated with pressure and volume under development and leber hereditary optic atrophy
13) Confidence 0.06 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605731 Disease Relevance 0.86 Pain Relevance 0
In MS, cerebrospinal fluid pNF-H levels increased in those with primary or secondary progressive disease, but in those with relapsing remitting disease pNF-H titers were elevated acutely and decreased later [40].
Positive_regulation (elevated) of pNF-H in cerebrospinal fluid associated with multiple sclerosis and disease
14) Confidence 0.06 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605731 Disease Relevance 1.53 Pain Relevance 0.37
Moreover, increased blood levels of pNF-H in some LHON patients suggest not all axons are lost but a number are still undergoing degeneration even many years after visual loss.
Positive_regulation (increased) of pNF-H in blood associated with leber hereditary optic atrophy
15) Confidence 0.06 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605731 Disease Relevance 1.01 Pain Relevance 0
Increases in pNF-H levels of carriers with increasing age, not seen in off-pedigree controls, may suggest subtle subclinical optic nerve degeneration.



Positive_regulation (Increases) of pNF-H in optic nerve associated with nerve degeneration
16) Confidence 0.06 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2605731 Disease Relevance 0.34 Pain Relevance 0
In MS, cerebrospinal fluid pNF-H levels increased in those with primary or secondary progressive disease, but in those with relapsing remitting disease pNF-H titers were elevated acutely and decreased later [40].
Positive_regulation (increased) of pNF-H in cerebrospinal fluid associated with multiple sclerosis and disease
17) Confidence 0.06 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605731 Disease Relevance 1.43 Pain Relevance 0.37

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