INT116625

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Context Info
Confidence 0.79
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 5.94
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nefh)
Anatomy Link Frequency
retinas 2
neurite 2
dendrites 1
RGC 1
Nefh (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 9 99.20 Very High Very High Very High
opioid receptor 1 97.68 Very High Very High Very High
Inflammation 9 92.96 High High
cerebral cortex 10 90.68 High High
Eae 12 87.20 High High
anesthesia 17 84.84 Quite High
Multiple sclerosis 19 79.56 Quite High
Kappa opioid receptor 2 79.20 Quite High
Spinal cord 2 75.68 Quite High
addiction 1 69.24 Quite High
Disease Link Frequency Relevance Heat
Injury 53 99.04 Very High Very High Very High
Multiple Sclerosis 24 98.36 Very High Very High Very High
Leber Hereditary Optic Atrophy 144 98.28 Very High Very High Very High
Death 81 95.00 High High
Ganglion Cysts 37 93.92 High High
INFLAMMATION 9 92.96 High High
Disease 71 90.96 High High
Decapitation 3 88.76 High High
Pressure And Volume Under Development 18 88.60 High High
Cognitive Disorder 39 87.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we demonstrate the validity of serum phosphorylated neurofilament H (pNF-H) as a marker of axonal injury in murine experimental autoimmune encephalomyelitis (EAE).
Phosphorylation (phosphorylated) of pNF-H associated with multiple sclerosis and injury
1) Confidence 0.79 Published 2008 Journal J. Neurosci. Res. Section Abstract Doc Link 18709652 Disease Relevance 1.61 Pain Relevance 0.25
In the present study, we demonstrate the validity of serum phosphorylated neurofilament H (pNF-H) as a marker of axonal injury in murine experimental autoimmune encephalomyelitis (EAE).
Phosphorylation (phosphorylated) of neurofilament H associated with multiple sclerosis and injury
2) Confidence 0.69 Published 2008 Journal J. Neurosci. Res. Section Abstract Doc Link 18709652 Disease Relevance 1.60 Pain Relevance 0.25
Also, the marked increase in phosphorylated NF-H induced by chronic morphine in WT mice (two-fold) was abolished in mu -KO mice.
Phosphorylation (phosphorylated) of NF-H associated with morphine
3) Confidence 0.42 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14975676 Disease Relevance 0.21 Pain Relevance 0.86
m coronal sections using a cryostat (CM3050S, Leica, Heidelberg, Germany), and the slices were fixed with 4% paraformaldehyde and stained with a monoclonal antibody against phosphorylated NF-H, MAP2, synaptophysin or MBP.
Phosphorylation (phosphorylated) of NF-H
4) Confidence 0.33 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.26 Pain Relevance 0.04
Five days later, the cells were fixed with 4% paraformaldehyde and then immunostained with a monoclonal antibody against phosphorylated NF-H (1:1000) as an axonal marker or a monoclonal antibody against MAP2 (1:1000) as a dendritic marker.
Phosphorylation (phosphorylated) of NF-H
5) Confidence 0.33 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0 Pain Relevance 0
The lengths of neurites that were positive for phosphorylated NF-H or MAP2 were measured using an image analyzer Neurocyte (Kurabo, Osaka, Japan) which detects neurite lengths.
Phosphorylation (phosphorylated) of NF-H in neurite
6) Confidence 0.25 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0 Pain Relevance 0
The neurites exhibited positive immunostaining for phosphorylated NF-H (Fig. 4A).
Phosphorylation (phosphorylated) of NF-H in neurites
7) Confidence 0.09 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0
Phosphorylated NF-H is localized in mature axons, but not in dendrites.
Phosphorylation (Phosphorylated) of NF-H in dendrites
8) Confidence 0.09 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0
We selected the phosphorylated high molecular weight form (NF-H) as a mature axon marker [24,31].
Phosphorylation (phosphorylated) of NF-H
9) Confidence 0.09 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0
Dissected retinas were stained with RT97, an antibody that recognizes phosphorylated neurofilament heavy chain (pNFH) and whose abnormal expression is an index of axonal injury [71,81-88].
Phosphorylation (phosphorylated) of neurofilament heavy chain in retinas associated with injury
10) Confidence 0.08 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.36 Pain Relevance 0
Dissected retinas were stained with RT97, an antibody that recognizes phosphorylated neurofilament heavy chain (pNFH) and whose abnormal expression is an index of axonal injury [71,81-88].
Phosphorylation (phosphorylated) of pNFH in retinas associated with injury
11) Confidence 0.08 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.36 Pain Relevance 0
They are released into the bloodstream with axonal disruption, and the heavily phosphorylated axonal form of NF-H, pNF-H, has a collection of unusual properties that render it resistant to proteases and relatively easy to detect with ELISA and other antibody-based assays.
Phosphorylation (phosphorylated) of pNF-H
12) Confidence 0.08 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605731 Disease Relevance 0.23 Pain Relevance 0
We quantitated serum levels of phosphorylated neurofilament heavy chain (pNF-H) in a Brazilian pedigree of 16 affected patients and 59 carriers with LHON, both molecularly characterized as harboring the G to A mutation at nucleotide 11,778 of the mitochondrial genome.
Phosphorylation (phosphorylated) of pNF-H associated with leber hereditary optic atrophy
13) Confidence 0.08 Published 2008 Journal Molecular Vision Section Abstract Doc Link PMC2605731 Disease Relevance 0.44 Pain Relevance 0
Since heavily phosphorylated axonal form of the neurofilament heavy chain (pNF-H) has been shown to be a prospective marker of neurodegeneration [25], we evaluated serum pNF-H levels in a large Brazilian pedigree [26,27] to determine the profile of axonal and RGC loss in LHON patients and asymptomatic carriers of mutated G11778A mtDNA.


Phosphorylation (phosphorylated) of pNF-H in RGC associated with leber hereditary optic atrophy
14) Confidence 0.08 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605731 Disease Relevance 0.86 Pain Relevance 0

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