INT116641

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Context Info
Confidence 0.71
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 55
Disease Relevance 4.30
Pain Relevance 6.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gsk3a) signal transduction (Gsk3a) carbohydrate metabolic process (Gsk3a)
Anatomy Link Frequency
neurons 13
muscle 2
frontal cortex 1
Gsk3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 334 99.92 Very High Very High Very High
nMDA receptor 189 99.74 Very High Very High Very High
Paracetamol 420 99.14 Very High Very High Very High
antagonist 195 97.96 Very High Very High Very High
Glutamate 242 96.72 Very High Very High Very High
depression 7 94.04 High High
antidepressant 14 91.24 High High
Opioid 11 75.00 Quite High
Hippocampus 9 74.52 Quite High
addiction 93 73.40 Quite High
Disease Link Frequency Relevance Heat
Stress 11 99.78 Very High Very High Very High
Urological Neuroanatomy 5 99.52 Very High Very High Very High
Apoptosis 646 96.24 Very High Very High Very High
Depression 7 94.04 High High
Aging 266 93.48 High High
Disease 43 88.36 High High
Death 291 88.16 High High
Tauopathy 1 73.20 Quite High
Cv Unclassified Under Development 15 72.20 Quite High
Tuberous Sclerosis 7 67.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prenatal stress decreases glycogen synthase kinase-3 phosphorylation in the rat frontal cortex.
Phosphorylation (phosphorylation) of glycogen synthase kinase-3 in frontal cortex associated with stress and urological neuroanatomy
1) Confidence 0.71 Published 2009 Journal Pharmacol Rep Section Title Doc Link 19815943 Disease Relevance 0.67 Pain Relevance 0.38
The phosphorylation of the GSK-3 fusion protein at Ser21/Ser9 by the immunoprecipitated Akt was detected by immunoblotting.
Phosphorylation (phosphorylation) of GSK-3
2) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.05 Pain Relevance 0
Using the in vitro Akt kinase activity assay we demonstrated that less GSK-3 fusion protein was phosphorylated by per unit of immunoprecipitated Akt obtained from very aged muscle.
Phosphorylation (phosphorylated) of GSK-3 in muscle
3) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.16 Pain Relevance 0.06
Acetaminophen administration increased the abundance of phosphorylated GSK-3 by 170.5% when compared to age-matched control (P<0.05).
Phosphorylation (phosphorylated) of GSK-3 associated with paracetamol
4) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.09 Pain Relevance 0.52
The amount of GSK-3 fusion protein that was phosphorylated by immunoprecipitated Akt from very aged control animals was decreased by 32.8% and 34.6%, respectively, when compared to that observed using the 6-month or 27-month rats (P<0.05; Figure 4A).
Phosphorylation (phosphorylated) of GSK-3
5) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.13 Pain Relevance 0.48
The phosphorylation levels of GSK3?
Phosphorylation (phosphorylation) of GSK3
6) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.09 Pain Relevance 0.59
After ex vivo incubation with insulin, the phosphorylation of Akt and the Akt downstream proteins, GSK-3?
Phosphorylation (phosphorylation) of GSK-3
7) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.09 Pain Relevance 0.54
Using an ex vivo approach resulted in a similar conclusion as the aged control muscles required higher levels of Akt phosphorylation (both Ser474 and Thr308) to phosphorylate similar amounts of GSK3?
Phosphorylation (phosphorylate) of GSK3 in muscles
8) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.23 Pain Relevance 0.10
It can be observed that when suboptimal concentrations of both effectors were added together, the levels of GSK3 phosphorylation were higher with respect to that obtained with either BzATP or NMDA alone.
Phosphorylation (phosphorylation) of GSK3
9) Confidence 0.16 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.14
In the present study the effect of BzATP on GSK3 phosphorylation was compared to other relevant extracellular signals in granule neurons, such as glutamate and BDNF.
Phosphorylation (phosphorylation) of GSK3 in neurons associated with glutamate
10) Confidence 0.16 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.14
In the present study, we have found out that NMDA and BDNF receptors are also coupled to GSK3 phosphorylation in granule neurons through both PKC and PI3K/Akt dependent mechanisms.
Phosphorylation (phosphorylation) of GSK3 in neurons
11) Confidence 0.16 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.25 Pain Relevance 0.03
Pre-treatment with the MAPK inhibitor, U-0126, was also able to diminish BDNF-induced recovery in the levels of GSK3 phosphorylation (Fig. 5c).
Phosphorylation (phosphorylation) of GSK3
12) Confidence 0.16 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.07 Pain Relevance 0
We demonstrated that BzATP-induced GSK3 phosphorylation was dependent on extracellular calcium, and sensitive to P2X7 specific antagonists [12].
Phosphorylation (phosphorylation) of GSK3 associated with antagonist
13) Confidence 0.16 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.14
In the case of NMDA and BzATP the increase percentages in GSK3 phosphorylation were in the same range, being always slightly higher for NMDA.Fig. 1GSK3 phosphorylation induced by BzATP, NMDA and BDNF in granule neurons. a Time-course of GSK3 phosphorylation.
Phosphorylation (phosphorylation) of GSK3 in neurons
14) Confidence 0.16 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.10
Then cells were harvested and phosphorylation of GSK3 was analysed by immunoblotting, as described in “Material and methods”.
Phosphorylation (phosphorylation) of GSK3
15) Confidence 0.16 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.07
Recent studies have further investigated the intracellular signalling mechanisms triggered by nucleotide receptors and have demonstrated the coupling of P2Y13 and P2X7 receptors to GSK3 phosphorylation in rat cerebellar granule neurons.
Phosphorylation (phosphorylation) of GSK3 in neurons
16) Confidence 0.16 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.05
From the present results it is clear that the full effect of NMDA-receptor activation on GSK3 phosphorylation is obtained primarily through a PKC-dependent pathway, in the same way that BzATP acting through P2X7 receptors.
Phosphorylation (phosphorylation) of GSK3
17) Confidence 0.16 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0.15 Pain Relevance 0.03
The activation of both these nucleotide receptors resulted in an increase in the phosphorylation levels of GSK3 at specific Ser residues that were associated with the inhibition of its catalytic activity [9].
Phosphorylation (phosphorylation) of GSK3
18) Confidence 0.16 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.04
In a previous work, the effect of several nucleotidic agonists on GSK3 phosphorylation was investigated, and among them, BzATP resulted to be the most potent, through the activation of the P2X7 nucleotide receptor.
Phosphorylation (phosphorylation) of GSK3 associated with agonist
19) Confidence 0.16 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.12
Figure 2a shows the dose–response curve for NMDA-induced GSK3 phosphorylation performed in the absence and presence of co-stimulation with the nucleotide agonist BzATP.
Phosphorylation (phosphorylation) of GSK3 associated with agonist
20) Confidence 0.16 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.16

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