INT116642

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Context Info
Confidence 0.57
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 7.16
Pain Relevance 3.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b) response to stress (Gsk3b)
cytoplasm (Gsk3b) cytosol (Gsk3b) nucleolus (Gsk3b)
Anatomy Link Frequency
myocytes 1
neurons 1
pore 1
hearts 1
Gsk3b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 24 99.86 Very High Very High Very High
Opioid 16 99.82 Very High Very High Very High
antidepressant 8 97.44 Very High Very High Very High
Serotonin 7 96.56 Very High Very High Very High
ischemia 15 94.96 High High
Enkephalin 2 89.52 High High
agonist 37 88.28 High High
opioid receptor 4 87.96 High High
Dopamine 141 83.12 Quite High
MU agonist 6 79.00 Quite High
Disease Link Frequency Relevance Heat
Major Depressive Disorder 8 99.88 Very High Very High Very High
Schizophrenia 443 98.66 Very High Very High Very High
Hematological Disease 3 98.48 Very High Very High Very High
Stress 42 98.38 Very High Very High Very High
Congenital Anomalies 88 97.98 Very High Very High Very High
Disease 58 97.24 Very High Very High Very High
Cv Unclassified Under Development 14 94.96 High High
Cancer 22 92.88 High High
Holoprosencephaly 10 92.40 High High
Familial Adenomatous Polyposis 10 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of GSK3B is thought to be a key feature in the therapeutic mechanism of antidepressants.
Negative_regulation (Inhibition) of GSK3B associated with antidepressant
1) Confidence 0.57 Published 2008 Journal Pharmacogenomics J. Section Abstract Doc Link 18195729 Disease Relevance 0.49 Pain Relevance 0.28
Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts.
Negative_regulation (inhibition) of glycogen synthase kinase in hearts associated with opioid
2) Confidence 0.43 Published 2004 Journal Circ. Res. Section Title Doc Link 14976126 Disease Relevance 0.19 Pain Relevance 0.59
Cardioprotective effect of morphine and a blocker of glycogen synthase kinase 3 beta, SB216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione], via inhibition of the mitochondrial permeability transition pore.
Negative_regulation (blocker) of glycogen synthase kinase 3 beta in pore associated with morphine
3) Confidence 0.41 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 18434587 Disease Relevance 0.33 Pain Relevance 0.54
Inhibition of Gsk3b results in decreased phosphorylation of ?
Negative_regulation (Inhibition) of Gsk3b
4) Confidence 0.34 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1281279 Disease Relevance 0.49 Pain Relevance 0
In addition, mRNA expression of Prkcz, an inhibitor of Gsk3b kinase activity, was up-regulated in response to PB and PTU animals but not NaI (Oriente et al. 2001).
Negative_regulation (inhibitor) of Gsk3b
5) Confidence 0.34 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1281279 Disease Relevance 0.58 Pain Relevance 0
We examined the role for the JAK/STAT signaling pathway in acute opioid-induced cardioprotection (OIC) and whether opioid-induced glycogen synthase kinase-3beta (GSK-3 beta) inhibition is mediated by the JAK/STAT pathway.
Negative_regulation (inhibition) of GSK-3 beta associated with opioid
6) Confidence 0.32 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16517948 Disease Relevance 0.16 Pain Relevance 0.58
We examined the role for the JAK/STAT signaling pathway in acute opioid-induced cardioprotection (OIC) and whether opioid-induced glycogen synthase kinase-3beta (GSK-3 beta) inhibition is mediated by the JAK/STAT pathway.
Negative_regulation (inhibition) of glycogen synthase kinase-3beta associated with opioid
7) Confidence 0.32 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16517948 Disease Relevance 0.16 Pain Relevance 0.58
Glycogen synthase kinase (GSK) inhibition produced by ischemic preconditioning has been previously shown to be regulated through phosphatidylinositol-3 kinase (PI3K).
Negative_regulation (inhibition) of Glycogen synthase kinase
8) Confidence 0.32 Published 2004 Journal Circ. Res. Section Abstract Doc Link 14976126 Disease Relevance 0 Pain Relevance 0.35
These experiments confirm that inhibition of GSK3 beta protects the myocytes, but also that the preconditioning mimetic DADLE loses its protective effect when a constitutively active GSK3 beta is present.
Negative_regulation (inhibition) of GSK3 beta in myocytes
9) Confidence 0.16 Published 2010 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 20337662 Disease Relevance 0.31 Pain Relevance 0.14
Cells transfected with dnGSK (1 micromol/L) were equally protected against peroxide stress, when given throughout the TMRE and H(2)O(2) treatment, confirming a protective effect of GSK3 beta with a highly selective inhibition.
Negative_regulation (effect) of GSK3 beta associated with stress
10) Confidence 0.12 Published 2010 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 20337662 Disease Relevance 0.34 Pain Relevance 0.24
In this case GSK-3beta is a negative regulator of Wnt.
Negative_regulation (regulator) of GSK-3beta
11) Confidence 0.12 Published 2008 Journal Curr. Med. Chem. Section Abstract Doc Link 18537625 Disease Relevance 0.56 Pain Relevance 0.03
In an earlier study, we found that serotonin (5-HT), acting through the 5-HT1A receptor subtype, promotes axonal transport of mitochondria in cultured hippocampal neurons by increasing Akt activity, and consequently decreasing glycogen synthase kinase (GSK3?)
Negative_regulation (decreasing) of glycogen synthase kinase in neurons associated with serotonin
12) Confidence 0.03 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2467486 Disease Relevance 0 Pain Relevance 0.25
The Zic2kd/+ mouse is an animal model for diseases of sensorimotor gating abnormalities which would include schizophrenia.215 Chronic and prenatal BPA exposures both produce a significant decrease and disruption of SH.175

Glial Cell LineĀ–Derived Neurotrophic Factor.

Negative_regulation (decrease) of Factor associated with congenital anomalies, disease and schizophrenia
13) Confidence 0.01 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 1.77 Pain Relevance 0.14
The Zic2kd/+ mouse is an animal model for diseases of sensorimotor gating abnormalities which would include schizophrenia.215 Chronic and prenatal BPA exposures both produce a significant decrease and disruption of SH.175

Glial Cell LineĀ–Derived Neurotrophic Factor.

Negative_regulation (disruption) of Factor associated with congenital anomalies, disease and schizophrenia
14) Confidence 0.01 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 1.76 Pain Relevance 0.14

General Comments

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